La nuova mano bionica che dialoga con muscoli e cervello

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Da una collaborazione tra l’UOC di Chirurgia plastica di Padova diretta dal Franco Bassetto, Nicola Petrone docente del Dipartimento di Ingegneria industriale dell’Università di Padova, il gruppo di ricerca dell’Università di Scienze applicate della Svizzera Occidentale coordinato da Manfredo Atzori e da Henning Müller, PlayCast Srl e Dynatec Studio nasce il progetto di ricerca ProHand, finanziato dalla fondazione svizzera Hasler.

Le protesi mioelettriche oggi disponibili presentano dei limiti, come ad esempio la adattabilità all'utente e la difficoltà di controllo, che le ricercatrici e i ricercatori italiani e svizzeri stanno provando a risolvere usando la tecnologia della scansione e della stampa 3D della protesi, che permette di ottenere protesi più economiche. Un altro limite è quello della presa vera e propria e della gamma di movimenti possibile: il team ha progettato da un lato un sistema di motori elettrici distribuiti su ogni dito, e dall’altro ha potuto usare i pattern di segnale registrati grazie ai progetti NinaPro e MeganePro per aumentare i movimenti e la loro precisione fino a 36 al momento il numero più elevato pubblicato in letteratura.

La scienza medica, grazie alle sempre più sofisticate tecniche di microchirurgia, in molti casi viene in aiuto con un reimpianto dell’arto stesso ma questo purtroppo non sempre è possibile. Si deve ricorrere così a un arto artificiale che negli ultimi anni da semplice “sostituto inerte” o quasi si sta trasformando in una vera e propria mano bionica grazie ai progressi della chirurgia plastica, della bioingegneria e della robotica.

L’evoluzione dell’uomo e il progresso portano in modo indelebile l’impronta della mano. Attraverso le mani l’uomo ha costruito un futuro sempre più minutamente preciso, strutturato, elaborato. Eppure in Italia ogni anno circa 4 abitanti su centomila subiscono traumi così gravi da determinare l’amputazione di una mano o di parte dell’avambraccio. «I progetti NinaPro e MeganePro hanno portato al database probabilmente più utilizzato al mondo per il controllo di protesi – spiega Atzori-. I muscoli che muovevano la mano, ancora presenti nell'avambraccio, si contraggono sollecitati dallo stimolo cerebrale del movimento. Gli impulsi elettrici emessi sono registrati tramite sensori e utilizzati per innescare i movimenti della protesi.».

«Quando non è possibile il reimpianto dell’arto il chirurgo plastico deve prestare la massima attenzione al “confezionamento” del moncone –sostiene Franco Bassetto – in quanto dipenderà da questo la possibilità in seguito da parte del paziente dell’utilizzo di protesi, dalle più semplici alle più innovative. L’amputazione deve essere effettuata con metodologia che permetta il più possibile la conservazione dei gruppi muscolari per poter così creare il miglior cuscinetto possibile funzionale all’impianto protesico».Grazie al lavoro del nostro Dipartimento abbiamo portato la mano robotica Padovana a prestazioni significative pur con tecnologie e costi accessibili– spiega Petrone.

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Da una collaborazione tra l’UOC di Chirurgia plastica di Padova diretta dal Franco Bassetto, Nicola Petrone docente del Dipartimento di Ingegneria industriale dell’Università di Padova, il gruppo di ricerca dell’Università di Scienze applicate della Svizzera Occidentale coordinato da Manfredo Atzori e da Henning Müller, PlayCast Srl e Dynatec Studio nasce il progetto di ricerca ProHand, finanziato dalla fondazione svizzera Hasler.

Le protesi mioelettriche oggi disponibili presentano dei limiti, come ad esempio la adattabilità all'utente e la difficoltà di controllo, che le ricercatrici e i ricercatori italiani e svizzeri stanno provando a risolvere usando la tecnologia della scansione e della stampa 3D della protesi, che permette di ottenere protesi più economiche. Un altro limite è quello della presa vera e propria e della gamma di movimenti possibile: il team ha progettato da un lato un sistema di motori elettrici distribuiti su ogni dito, e dall’altro ha potuto usare i pattern di segnale registrati grazie ai progetti NinaPro e MeganePro per aumentare i movimenti e la loro precisione fino a 36 al momento il numero più elevato pubblicato in letteratura.

La scienza medica, grazie alle sempre più sofisticate tecniche di microchirurgia, in molti casi viene in aiuto con un reimpianto dell’arto stesso ma questo purtroppo non sempre è possibile. Si deve ricorrere così a un arto artificiale che negli ultimi anni da semplice “sostituto inerte” o quasi si sta trasformando in una vera e propria mano bionica grazie ai progressi della chirurgia plastica, della bioingegneria e della robotica.

L’evoluzione dell’uomo e il progresso portano in modo indelebile l’impronta della mano. Attraverso le mani l’uomo ha costruito un futuro sempre più minutamente preciso, strutturato, elaborato. Eppure in Italia ogni anno circa 4 abitanti su centomila subiscono traumi così gravi da determinare l’amputazione di una mano o di parte dell’avambraccio. «I progetti NinaPro e MeganePro hanno portato al database probabilmente più utilizzato al mondo per il controllo di protesi – spiega Atzori-. I muscoli che muovevano la mano, ancora presenti nell'avambraccio, si contraggono sollecitati dallo stimolo cerebrale del movimento. Gli impulsi elettrici emessi sono registrati tramite sensori e utilizzati per innescare i movimenti della protesi.».

«Quando non è possibile il reimpianto dell’arto il chirurgo plastico deve prestare la massima attenzione al “confezionamento” del moncone –sostiene Franco Bassetto – in quanto dipenderà da questo la possibilità in seguito da parte del paziente dell’utilizzo di protesi, dalle più semplici alle più innovative. L’amputazione deve essere effettuata con metodologia che permetta il più possibile la conservazione dei gruppi muscolari per poter così creare il miglior cuscinetto possibile funzionale all’impianto protesico».Grazie al lavoro del nostro Dipartimento abbiamo portato la mano robotica Padovana a prestazioni significative pur con tecnologie e costi accessibili– spiega Petrone.

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Da una collaborazione tra l’UOC di Chirurgia plastica di Padova diretta dal Franco Bassetto, Nicola Petrone docente del Dipartimento di Ingegneria industriale dell’Università di Padova, il gruppo di ricerca dell’Università di Scienze applicate della Svizzera Occidentale coordinato da Manfredo Atzori e da Henning Müller, PlayCast Srl e Dynatec Studio nasce il progetto di ricerca ProHand, finanziato dalla fondazione svizzera Hasler.

Le protesi mioelettriche oggi disponibili presentano dei limiti, come ad esempio la adattabilità all'utente e la difficoltà di controllo, che le ricercatrici e i ricercatori italiani e svizzeri stanno provando a risolvere usando la tecnologia della scansione e della stampa 3D della protesi, che permette di ottenere protesi più economiche. Un altro limite è quello della presa vera e propria e della gamma di movimenti possibile: il team ha progettato da un lato un sistema di motori elettrici distribuiti su ogni dito, e dall’altro ha potuto usare i pattern di segnale registrati grazie ai progetti NinaPro e MeganePro per aumentare i movimenti e la loro precisione fino a 36 al momento il numero più elevato pubblicato in letteratura.

La scienza medica, grazie alle sempre più sofisticate tecniche di microchirurgia, in molti casi viene in aiuto con un reimpianto dell’arto stesso ma questo purtroppo non sempre è possibile. Si deve ricorrere così a un arto artificiale che negli ultimi anni da semplice “sostituto inerte” o quasi si sta trasformando in una vera e propria mano bionica grazie ai progressi della chirurgia plastica, della bioingegneria e della robotica.

L’evoluzione dell’uomo e il progresso portano in modo indelebile l’impronta della mano. Attraverso le mani l’uomo ha costruito un futuro sempre più minutamente preciso, strutturato, elaborato. Eppure in Italia ogni anno circa 4 abitanti su centomila subiscono traumi così gravi da determinare l’amputazione di una mano o di parte dell’avambraccio. «I progetti NinaPro e MeganePro hanno portato al database probabilmente più utilizzato al mondo per il controllo di protesi – spiega Atzori-. I muscoli che muovevano la mano, ancora presenti nell'avambraccio, si contraggono sollecitati dallo stimolo cerebrale del movimento. Gli impulsi elettrici emessi sono registrati tramite sensori e utilizzati per innescare i movimenti della protesi.».

«Quando non è possibile il reimpianto dell’arto il chirurgo plastico deve prestare la massima attenzione al “confezionamento” del moncone –sostiene Franco Bassetto – in quanto dipenderà da questo la possibilità in seguito da parte del paziente dell’utilizzo di protesi, dalle più semplici alle più innovative. L’amputazione deve essere effettuata con metodologia che permetta il più possibile la conservazione dei gruppi muscolari per poter così creare il miglior cuscinetto possibile funzionale all’impianto protesico».Grazie al lavoro del nostro Dipartimento abbiamo portato la mano robotica Padovana a prestazioni significative pur con tecnologie e costi accessibili– spiega Petrone.

[summary] => [format] => 2 [safe_value] =>

Da una collaborazione tra l’UOC di Chirurgia plastica di Padova diretta dal Franco Bassetto, Nicola Petrone docente del Dipartimento di Ingegneria industriale dell’Università di Padova, il gruppo di ricerca dell’Università di Scienze applicate della Svizzera Occidentale coordinato da Manfredo Atzori e da Henning Müller, PlayCast Srl e Dynatec Studio nasce il progetto di ricerca ProHand, finanziato dalla fondazione svizzera Hasler.

Le protesi mioelettriche oggi disponibili presentano dei limiti, come ad esempio la adattabilità all'utente e la difficoltà di controllo, che le ricercatrici e i ricercatori italiani e svizzeri stanno provando a risolvere usando la tecnologia della scansione e della stampa 3D della protesi, che permette di ottenere protesi più economiche. Un altro limite è quello della presa vera e propria e della gamma di movimenti possibile: il team ha progettato da un lato un sistema di motori elettrici distribuiti su ogni dito, e dall’altro ha potuto usare i pattern di segnale registrati grazie ai progetti NinaPro e MeganePro per aumentare i movimenti e la loro precisione fino a 36 al momento il numero più elevato pubblicato in letteratura.

La scienza medica, grazie alle sempre più sofisticate tecniche di microchirurgia, in molti casi viene in aiuto con un reimpianto dell’arto stesso ma questo purtroppo non sempre è possibile. Si deve ricorrere così a un arto artificiale che negli ultimi anni da semplice “sostituto inerte” o quasi si sta trasformando in una vera e propria mano bionica grazie ai progressi della chirurgia plastica, della bioingegneria e della robotica.

L’evoluzione dell’uomo e il progresso portano in modo indelebile l’impronta della mano. Attraverso le mani l’uomo ha costruito un futuro sempre più minutamente preciso, strutturato, elaborato. Eppure in Italia ogni anno circa 4 abitanti su centomila subiscono traumi così gravi da determinare l’amputazione di una mano o di parte dell’avambraccio. «I progetti NinaPro e MeganePro hanno portato al database probabilmente più utilizzato al mondo per il controllo di protesi – spiega Atzori-. I muscoli che muovevano la mano, ancora presenti nell'avambraccio, si contraggono sollecitati dallo stimolo cerebrale del movimento. Gli impulsi elettrici emessi sono registrati tramite sensori e utilizzati per innescare i movimenti della protesi.».

«Quando non è possibile il reimpianto dell’arto il chirurgo plastico deve prestare la massima attenzione al “confezionamento” del moncone –sostiene Franco Bassetto – in quanto dipenderà da questo la possibilità in seguito da parte del paziente dell’utilizzo di protesi, dalle più semplici alle più innovative. L’amputazione deve essere effettuata con metodologia che permetta il più possibile la conservazione dei gruppi muscolari per poter così creare il miglior cuscinetto possibile funzionale all’impianto protesico».Grazie al lavoro del nostro Dipartimento abbiamo portato la mano robotica Padovana a prestazioni significative pur con tecnologie e costi accessibili– spiega Petrone.

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Da una collaborazione tra l’UOC di Chirurgia plastica di Padova diretta dal Franco Bassetto, Nicola Petrone docente del Dipartimento di Ingegneria industriale dell’Università di Padova, il gruppo di ricerca dell’Università di Scienze applicate della Svizzera Occidentale coordinato da Manfredo Atzori e da Henning Müller, PlayCast Srl e Dynatec Studio nasce il progetto di ricerca ProHand, finanziato dalla fondazione svizzera Hasler.

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Da una collaborazione tra l’UOC di Chirurgia plastica di Padova diretta dal Franco Bassetto, Nicola Petrone docente del Dipartimento di Ingegneria industriale dell’Università di Padova, il gruppo di ricerca dell’Università di Scienze applicate della Svizzera Occidentale coordinato da Manfredo Atzori e da Henning Müller, PlayCast Srl e Dynatec Studio nasce il progetto di ricerca ProHand, finanziato dalla fondazione svizzera Hasler.

Le protesi mioelettriche oggi disponibili presentano dei limiti, come ad esempio la adattabilità all'utente e la difficoltà di controllo, che le ricercatrici e i ricercatori italiani e svizzeri stanno provando a risolvere usando la tecnologia della scansione e della stampa 3D della protesi, che permette di ottenere protesi più economiche. Un altro limite è quello della presa vera e propria e della gamma di movimenti possibile: il team ha progettato da un lato un sistema di motori elettrici distribuiti su ogni dito, e dall’altro ha potuto usare i pattern di segnale registrati grazie ai progetti NinaPro e MeganePro per aumentare i movimenti e la loro precisione fino a 36 al momento il numero più elevato pubblicato in letteratura.

La scienza medica, grazie alle sempre più sofisticate tecniche di microchirurgia, in molti casi viene in aiuto con un reimpianto dell’arto stesso ma questo purtroppo non sempre è possibile. Si deve ricorrere così a un arto artificiale che negli ultimi anni da semplice “sostituto inerte” o quasi si sta trasformando in una vera e propria mano bionica grazie ai progressi della chirurgia plastica, della bioingegneria e della robotica.

L’evoluzione dell’uomo e il progresso portano in modo indelebile l’impronta della mano. Attraverso le mani l’uomo ha costruito un futuro sempre più minutamente preciso, strutturato, elaborato. Eppure in Italia ogni anno circa 4 abitanti su centomila subiscono traumi così gravi da determinare l’amputazione di una mano o di parte dell’avambraccio. «I progetti NinaPro e MeganePro hanno portato al database probabilmente più utilizzato al mondo per il controllo di protesi – spiega Atzori-. I muscoli che muovevano la mano, ancora presenti nell'avambraccio, si contraggono sollecitati dallo stimolo cerebrale del movimento. Gli impulsi elettrici emessi sono registrati tramite sensori e utilizzati per innescare i movimenti della protesi.».

«Quando non è possibile il reimpianto dell’arto il chirurgo plastico deve prestare la massima attenzione al “confezionamento” del moncone –sostiene Franco Bassetto – in quanto dipenderà da questo la possibilità in seguito da parte del paziente dell’utilizzo di protesi, dalle più semplici alle più innovative. L’amputazione deve essere effettuata con metodologia che permetta il più possibile la conservazione dei gruppi muscolari per poter così creare il miglior cuscinetto possibile funzionale all’impianto protesico».Grazie al lavoro del nostro Dipartimento abbiamo portato la mano robotica Padovana a prestazioni significative pur con tecnologie e costi accessibili– spiega Petrone.

[summary] => [format] => 2 [safe_value] =>

Da una collaborazione tra l’UOC di Chirurgia plastica di Padova diretta dal Franco Bassetto, Nicola Petrone docente del Dipartimento di Ingegneria industriale dell’Università di Padova, il gruppo di ricerca dell’Università di Scienze applicate della Svizzera Occidentale coordinato da Manfredo Atzori e da Henning Müller, PlayCast Srl e Dynatec Studio nasce il progetto di ricerca ProHand, finanziato dalla fondazione svizzera Hasler.

Le protesi mioelettriche oggi disponibili presentano dei limiti, come ad esempio la adattabilità all'utente e la difficoltà di controllo, che le ricercatrici e i ricercatori italiani e svizzeri stanno provando a risolvere usando la tecnologia della scansione e della stampa 3D della protesi, che permette di ottenere protesi più economiche. Un altro limite è quello della presa vera e propria e della gamma di movimenti possibile: il team ha progettato da un lato un sistema di motori elettrici distribuiti su ogni dito, e dall’altro ha potuto usare i pattern di segnale registrati grazie ai progetti NinaPro e MeganePro per aumentare i movimenti e la loro precisione fino a 36 al momento il numero più elevato pubblicato in letteratura.

La scienza medica, grazie alle sempre più sofisticate tecniche di microchirurgia, in molti casi viene in aiuto con un reimpianto dell’arto stesso ma questo purtroppo non sempre è possibile. Si deve ricorrere così a un arto artificiale che negli ultimi anni da semplice “sostituto inerte” o quasi si sta trasformando in una vera e propria mano bionica grazie ai progressi della chirurgia plastica, della bioingegneria e della robotica.

L’evoluzione dell’uomo e il progresso portano in modo indelebile l’impronta della mano. Attraverso le mani l’uomo ha costruito un futuro sempre più minutamente preciso, strutturato, elaborato. Eppure in Italia ogni anno circa 4 abitanti su centomila subiscono traumi così gravi da determinare l’amputazione di una mano o di parte dell’avambraccio. «I progetti NinaPro e MeganePro hanno portato al database probabilmente più utilizzato al mondo per il controllo di protesi – spiega Atzori-. I muscoli che muovevano la mano, ancora presenti nell'avambraccio, si contraggono sollecitati dallo stimolo cerebrale del movimento. Gli impulsi elettrici emessi sono registrati tramite sensori e utilizzati per innescare i movimenti della protesi.».

«Quando non è possibile il reimpianto dell’arto il chirurgo plastico deve prestare la massima attenzione al “confezionamento” del moncone –sostiene Franco Bassetto – in quanto dipenderà da questo la possibilità in seguito da parte del paziente dell’utilizzo di protesi, dalle più semplici alle più innovative. L’amputazione deve essere effettuata con metodologia che permetta il più possibile la conservazione dei gruppi muscolari per poter così creare il miglior cuscinetto possibile funzionale all’impianto protesico».Grazie al lavoro del nostro Dipartimento abbiamo portato la mano robotica Padovana a prestazioni significative pur con tecnologie e costi accessibili– spiega Petrone.

[safe_summary] => ) ) ) [field_date_box_lancio_news] => Array ( [und] => Array ( [0] => Array ( [value] => 2020-12-03T00:00:00 [timezone] => Europe/Paris [timezone_db] => Europe/Paris [date_type] => date ) ) ) [field_etichetta_box_lancio_news] => Array ( ) [field_img_box_lancio_news] => Array ( [und] => Array ( [0] => Array ( [fid] => 88267 [uid] => 2032 [filename] => n_robotics_idea.jpg [uri] => public://n_robotics_idea_0.jpg [filemime] => image/jpeg [filesize] => 82446 [status] => 1 [timestamp] => 1606988308 [type] => image [field_file_image_alt_text] => Array ( ) [field_file_image_title_text] => Array ( ) [field_folder] => Array ( [und] => Array ( [0] => Array ( [tid] => 2048 ) ) ) [metadata] => Array ( [height] => 590 [width] => 1200 ) [height] => 590 [width] => 1200 [alt] => robot [title] => ) ) ) [field_link_alla_news] => Array ( ) [field_link_esterno_news] => Array ( ) [field_pagina_associata] => Array ( ) [field_link_etichetta] => Array ( ) [field_abstract_news] => Array ( [und] => Array ( [0] => Array ( [value] => Un team di ricerca internazionale nato dalla collaborazione tra l’UOC di Chirurgia plastica di Padova, il Dipartimento di Ingegneria Industriale dell’Università di Padova, l’Università di Scienze applicate della Svizzera Occidentale, PlayCast Srl e Dynatec Studio, ha dato via al progetto di ricerca ProHand, rivolto alla creazione di nuove protesi bioniche sofisticate [format] => [safe_value] => Un team di ricerca internazionale nato dalla collaborazione tra l’UOC di Chirurgia plastica di Padova, il Dipartimento di Ingegneria Industriale dell’Università di Padova, l’Università di Scienze applicate della Svizzera Occidentale, PlayCast Srl e Dynatec Studio, ha dato via al progetto di ricerca ProHand, rivolto alla creazione di nuove protesi bioniche sofisticate ) ) ) [field_allegato_news] => Array ( ) [field_categorie_news] => Array ( [und] => Array ( [0] => Array ( [tid] => 2264 ) [1] => Array ( [tid] => 2267 ) ) ) [field_pub_date] => Array ( [und] => Array ( [0] => Array ( [value] => 2020-12-03T00:00:00 [value2] => 2021-04-03T00:00:00 [timezone] => Europe/Paris [timezone_db] => Europe/Paris [date_type] => date ) ) ) [field_layout_news] => Array ( [und] => Array ( [0] => Array ( [value] => single ) ) ) [field_testo_opzionale_news] => Array ( ) [field_url_en_page] => Array ( ) [field_url_en_page_label] => Array ( ) [path] => Array ( [pathauto] => 1 ) [name] => francesca.forzan [picture] => 0 [data] => b:0; [num_revisions] => 6 [current_revision_id] => 340899 [is_current] => 1 [is_pending] => [revision_moderation] => [entity_view_prepared] => 1 ) [#items] => Array ( [0] => Array ( [fid] => 88267 [uid] => 2032 [filename] => n_robotics_idea.jpg [uri] => public://n_robotics_idea_0.jpg [filemime] => image/jpeg [filesize] => 82446 [status] => 1 [timestamp] => 1606988308 [type] => image [field_file_image_alt_text] => Array ( ) [field_file_image_title_text] => Array ( ) [field_folder] => Array ( [und] => Array ( [0] => Array ( [tid] => 2048 ) ) ) [metadata] => Array ( [height] => 590 [width] => 1200 ) [height] => 590 [width] => 1200 [alt] => robot [title] => ) ) [#formatter] => image [0] => Array ( [#theme] => image_formatter [#item] => Array ( [fid] => 88267 [uid] => 2032 [filename] => n_robotics_idea.jpg [uri] => public://n_robotics_idea_0.jpg [filemime] => image/jpeg [filesize] => 82446 [status] => 1 [timestamp] => 1606988308 [type] => image [field_file_image_alt_text] => Array ( ) [field_file_image_title_text] => Array ( ) [field_folder] => Array ( [und] => Array ( [0] => Array ( [tid] => 2048 ) ) ) [metadata] => Array ( [height] => 590 [width] => 1200 ) [height] => 590 [width] => 1200 [alt] => robot [title] => ) [#image_style] => [#path] => ) ) [field_abstract_news] => Array ( [#theme] => field [#weight] => 0 [#title] => Abstract [#access] => 1 [#label_display] => above [#view_mode] => teaser [#language] => und [#field_name] => field_abstract_news [#field_type] => text_long [#field_translatable] => 0 [#entity_type] => node [#bundle] => box_lancio_news [#object] => stdClass Object ( [vid] => 340899 [uid] => 2032 [title] => La nuova mano bionica che dialoga con muscoli e cervello [log] => [status] => 1 [comment] => 0 [promote] => 1 [sticky] => 0 [nid] => 73590 [type] => box_lancio_news [language] => it [created] => 1606988135 [changed] => 1606988783 [tnid] => 0 [translate] => 0 [revision_timestamp] => 1606988783 [revision_uid] => 2032 [body] => Array ( [und] => Array ( [0] => Array ( [value] =>

Da una collaborazione tra l’UOC di Chirurgia plastica di Padova diretta dal Franco Bassetto, Nicola Petrone docente del Dipartimento di Ingegneria industriale dell’Università di Padova, il gruppo di ricerca dell’Università di Scienze applicate della Svizzera Occidentale coordinato da Manfredo Atzori e da Henning Müller, PlayCast Srl e Dynatec Studio nasce il progetto di ricerca ProHand, finanziato dalla fondazione svizzera Hasler.

Le protesi mioelettriche oggi disponibili presentano dei limiti, come ad esempio la adattabilità all'utente e la difficoltà di controllo, che le ricercatrici e i ricercatori italiani e svizzeri stanno provando a risolvere usando la tecnologia della scansione e della stampa 3D della protesi, che permette di ottenere protesi più economiche. Un altro limite è quello della presa vera e propria e della gamma di movimenti possibile: il team ha progettato da un lato un sistema di motori elettrici distribuiti su ogni dito, e dall’altro ha potuto usare i pattern di segnale registrati grazie ai progetti NinaPro e MeganePro per aumentare i movimenti e la loro precisione fino a 36 al momento il numero più elevato pubblicato in letteratura.

La scienza medica, grazie alle sempre più sofisticate tecniche di microchirurgia, in molti casi viene in aiuto con un reimpianto dell’arto stesso ma questo purtroppo non sempre è possibile. Si deve ricorrere così a un arto artificiale che negli ultimi anni da semplice “sostituto inerte” o quasi si sta trasformando in una vera e propria mano bionica grazie ai progressi della chirurgia plastica, della bioingegneria e della robotica.

L’evoluzione dell’uomo e il progresso portano in modo indelebile l’impronta della mano. Attraverso le mani l’uomo ha costruito un futuro sempre più minutamente preciso, strutturato, elaborato. Eppure in Italia ogni anno circa 4 abitanti su centomila subiscono traumi così gravi da determinare l’amputazione di una mano o di parte dell’avambraccio. «I progetti NinaPro e MeganePro hanno portato al database probabilmente più utilizzato al mondo per il controllo di protesi – spiega Atzori-. I muscoli che muovevano la mano, ancora presenti nell'avambraccio, si contraggono sollecitati dallo stimolo cerebrale del movimento. Gli impulsi elettrici emessi sono registrati tramite sensori e utilizzati per innescare i movimenti della protesi.».

«Quando non è possibile il reimpianto dell’arto il chirurgo plastico deve prestare la massima attenzione al “confezionamento” del moncone –sostiene Franco Bassetto – in quanto dipenderà da questo la possibilità in seguito da parte del paziente dell’utilizzo di protesi, dalle più semplici alle più innovative. L’amputazione deve essere effettuata con metodologia che permetta il più possibile la conservazione dei gruppi muscolari per poter così creare il miglior cuscinetto possibile funzionale all’impianto protesico».Grazie al lavoro del nostro Dipartimento abbiamo portato la mano robotica Padovana a prestazioni significative pur con tecnologie e costi accessibili– spiega Petrone.

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Da una collaborazione tra l’UOC di Chirurgia plastica di Padova diretta dal Franco Bassetto, Nicola Petrone docente del Dipartimento di Ingegneria industriale dell’Università di Padova, il gruppo di ricerca dell’Università di Scienze applicate della Svizzera Occidentale coordinato da Manfredo Atzori e da Henning Müller, PlayCast Srl e Dynatec Studio nasce il progetto di ricerca ProHand, finanziato dalla fondazione svizzera Hasler.

Le protesi mioelettriche oggi disponibili presentano dei limiti, come ad esempio la adattabilità all'utente e la difficoltà di controllo, che le ricercatrici e i ricercatori italiani e svizzeri stanno provando a risolvere usando la tecnologia della scansione e della stampa 3D della protesi, che permette di ottenere protesi più economiche. Un altro limite è quello della presa vera e propria e della gamma di movimenti possibile: il team ha progettato da un lato un sistema di motori elettrici distribuiti su ogni dito, e dall’altro ha potuto usare i pattern di segnale registrati grazie ai progetti NinaPro e MeganePro per aumentare i movimenti e la loro precisione fino a 36 al momento il numero più elevato pubblicato in letteratura.

La scienza medica, grazie alle sempre più sofisticate tecniche di microchirurgia, in molti casi viene in aiuto con un reimpianto dell’arto stesso ma questo purtroppo non sempre è possibile. Si deve ricorrere così a un arto artificiale che negli ultimi anni da semplice “sostituto inerte” o quasi si sta trasformando in una vera e propria mano bionica grazie ai progressi della chirurgia plastica, della bioingegneria e della robotica.

L’evoluzione dell’uomo e il progresso portano in modo indelebile l’impronta della mano. Attraverso le mani l’uomo ha costruito un futuro sempre più minutamente preciso, strutturato, elaborato. Eppure in Italia ogni anno circa 4 abitanti su centomila subiscono traumi così gravi da determinare l’amputazione di una mano o di parte dell’avambraccio. «I progetti NinaPro e MeganePro hanno portato al database probabilmente più utilizzato al mondo per il controllo di protesi – spiega Atzori-. I muscoli che muovevano la mano, ancora presenti nell'avambraccio, si contraggono sollecitati dallo stimolo cerebrale del movimento. Gli impulsi elettrici emessi sono registrati tramite sensori e utilizzati per innescare i movimenti della protesi.».

«Quando non è possibile il reimpianto dell’arto il chirurgo plastico deve prestare la massima attenzione al “confezionamento” del moncone –sostiene Franco Bassetto – in quanto dipenderà da questo la possibilità in seguito da parte del paziente dell’utilizzo di protesi, dalle più semplici alle più innovative. L’amputazione deve essere effettuata con metodologia che permetta il più possibile la conservazione dei gruppi muscolari per poter così creare il miglior cuscinetto possibile funzionale all’impianto protesico».Grazie al lavoro del nostro Dipartimento abbiamo portato la mano robotica Padovana a prestazioni significative pur con tecnologie e costi accessibili– spiega Petrone.

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Da una collaborazione tra l’UOC di Chirurgia plastica di Padova diretta dal Franco Bassetto, Nicola Petrone docente del Dipartimento di Ingegneria industriale dell’Università di Padova, il gruppo di ricerca dell’Università di Scienze applicate della Svizzera Occidentale coordinato da Manfredo Atzori e da Henning Müller, PlayCast Srl e Dynatec Studio nasce il progetto di ricerca ProHand, finanziato dalla fondazione svizzera Hasler.

Le protesi mioelettriche oggi disponibili presentano dei limiti, come ad esempio la adattabilità all'utente e la difficoltà di controllo, che le ricercatrici e i ricercatori italiani e svizzeri stanno provando a risolvere usando la tecnologia della scansione e della stampa 3D della protesi, che permette di ottenere protesi più economiche. Un altro limite è quello della presa vera e propria e della gamma di movimenti possibile: il team ha progettato da un lato un sistema di motori elettrici distribuiti su ogni dito, e dall’altro ha potuto usare i pattern di segnale registrati grazie ai progetti NinaPro e MeganePro per aumentare i movimenti e la loro precisione fino a 36 al momento il numero più elevato pubblicato in letteratura.

La scienza medica, grazie alle sempre più sofisticate tecniche di microchirurgia, in molti casi viene in aiuto con un reimpianto dell’arto stesso ma questo purtroppo non sempre è possibile. Si deve ricorrere così a un arto artificiale che negli ultimi anni da semplice “sostituto inerte” o quasi si sta trasformando in una vera e propria mano bionica grazie ai progressi della chirurgia plastica, della bioingegneria e della robotica.

L’evoluzione dell’uomo e il progresso portano in modo indelebile l’impronta della mano. Attraverso le mani l’uomo ha costruito un futuro sempre più minutamente preciso, strutturato, elaborato. Eppure in Italia ogni anno circa 4 abitanti su centomila subiscono traumi così gravi da determinare l’amputazione di una mano o di parte dell’avambraccio. «I progetti NinaPro e MeganePro hanno portato al database probabilmente più utilizzato al mondo per il controllo di protesi – spiega Atzori-. I muscoli che muovevano la mano, ancora presenti nell'avambraccio, si contraggono sollecitati dallo stimolo cerebrale del movimento. Gli impulsi elettrici emessi sono registrati tramite sensori e utilizzati per innescare i movimenti della protesi.».

«Quando non è possibile il reimpianto dell’arto il chirurgo plastico deve prestare la massima attenzione al “confezionamento” del moncone –sostiene Franco Bassetto – in quanto dipenderà da questo la possibilità in seguito da parte del paziente dell’utilizzo di protesi, dalle più semplici alle più innovative. L’amputazione deve essere effettuata con metodologia che permetta il più possibile la conservazione dei gruppi muscolari per poter così creare il miglior cuscinetto possibile funzionale all’impianto protesico».Grazie al lavoro del nostro Dipartimento abbiamo portato la mano robotica Padovana a prestazioni significative pur con tecnologie e costi accessibili– spiega Petrone.

[summary] => [format] => 2 [safe_value] =>

Da una collaborazione tra l’UOC di Chirurgia plastica di Padova diretta dal Franco Bassetto, Nicola Petrone docente del Dipartimento di Ingegneria industriale dell’Università di Padova, il gruppo di ricerca dell’Università di Scienze applicate della Svizzera Occidentale coordinato da Manfredo Atzori e da Henning Müller, PlayCast Srl e Dynatec Studio nasce il progetto di ricerca ProHand, finanziato dalla fondazione svizzera Hasler.

Le protesi mioelettriche oggi disponibili presentano dei limiti, come ad esempio la adattabilità all'utente e la difficoltà di controllo, che le ricercatrici e i ricercatori italiani e svizzeri stanno provando a risolvere usando la tecnologia della scansione e della stampa 3D della protesi, che permette di ottenere protesi più economiche. Un altro limite è quello della presa vera e propria e della gamma di movimenti possibile: il team ha progettato da un lato un sistema di motori elettrici distribuiti su ogni dito, e dall’altro ha potuto usare i pattern di segnale registrati grazie ai progetti NinaPro e MeganePro per aumentare i movimenti e la loro precisione fino a 36 al momento il numero più elevato pubblicato in letteratura.

La scienza medica, grazie alle sempre più sofisticate tecniche di microchirurgia, in molti casi viene in aiuto con un reimpianto dell’arto stesso ma questo purtroppo non sempre è possibile. Si deve ricorrere così a un arto artificiale che negli ultimi anni da semplice “sostituto inerte” o quasi si sta trasformando in una vera e propria mano bionica grazie ai progressi della chirurgia plastica, della bioingegneria e della robotica.

L’evoluzione dell’uomo e il progresso portano in modo indelebile l’impronta della mano. Attraverso le mani l’uomo ha costruito un futuro sempre più minutamente preciso, strutturato, elaborato. Eppure in Italia ogni anno circa 4 abitanti su centomila subiscono traumi così gravi da determinare l’amputazione di una mano o di parte dell’avambraccio. «I progetti NinaPro e MeganePro hanno portato al database probabilmente più utilizzato al mondo per il controllo di protesi – spiega Atzori-. I muscoli che muovevano la mano, ancora presenti nell'avambraccio, si contraggono sollecitati dallo stimolo cerebrale del movimento. Gli impulsi elettrici emessi sono registrati tramite sensori e utilizzati per innescare i movimenti della protesi.».

«Quando non è possibile il reimpianto dell’arto il chirurgo plastico deve prestare la massima attenzione al “confezionamento” del moncone –sostiene Franco Bassetto – in quanto dipenderà da questo la possibilità in seguito da parte del paziente dell’utilizzo di protesi, dalle più semplici alle più innovative. L’amputazione deve essere effettuata con metodologia che permetta il più possibile la conservazione dei gruppi muscolari per poter così creare il miglior cuscinetto possibile funzionale all’impianto protesico».Grazie al lavoro del nostro Dipartimento abbiamo portato la mano robotica Padovana a prestazioni significative pur con tecnologie e costi accessibili– spiega Petrone.

[safe_summary] => ) ) ) [field_date_box_lancio_news] => Array ( [und] => Array ( [0] => Array ( [value] => 2020-12-03T00:00:00 [timezone] => Europe/Paris [timezone_db] => Europe/Paris [date_type] => date ) ) ) [field_etichetta_box_lancio_news] => Array ( ) [field_img_box_lancio_news] => Array ( [und] => Array ( [0] => Array ( [fid] => 88267 [uid] => 2032 [filename] => n_robotics_idea.jpg [uri] => public://n_robotics_idea_0.jpg [filemime] => image/jpeg [filesize] => 82446 [status] => 1 [timestamp] => 1606988308 [type] => image [field_file_image_alt_text] => Array ( ) [field_file_image_title_text] => Array ( ) [field_folder] => Array ( [und] => Array ( [0] => Array ( [tid] => 2048 ) ) ) [metadata] => Array ( [height] => 590 [width] => 1200 ) [height] => 590 [width] => 1200 [alt] => robot [title] => ) ) ) [field_link_alla_news] => Array ( ) [field_link_esterno_news] => Array ( ) [field_pagina_associata] => Array ( ) [field_link_etichetta] => Array ( ) [field_abstract_news] => Array ( [und] => Array ( [0] => Array ( [value] => Un team di ricerca internazionale nato dalla collaborazione tra l’UOC di Chirurgia plastica di Padova, il Dipartimento di Ingegneria Industriale dell’Università di Padova, l’Università di Scienze applicate della Svizzera Occidentale, PlayCast Srl e Dynatec Studio, ha dato via al progetto di ricerca ProHand, rivolto alla creazione di nuove protesi bioniche sofisticate [format] => [safe_value] => Un team di ricerca internazionale nato dalla collaborazione tra l’UOC di Chirurgia plastica di Padova, il Dipartimento di Ingegneria Industriale dell’Università di Padova, l’Università di Scienze applicate della Svizzera Occidentale, PlayCast Srl e Dynatec Studio, ha dato via al progetto di ricerca ProHand, rivolto alla creazione di nuove protesi bioniche sofisticate ) ) ) [field_allegato_news] => Array ( ) [field_categorie_news] => Array ( [und] => Array ( [0] => Array ( [tid] => 2264 ) [1] => Array ( [tid] => 2267 ) ) ) [field_pub_date] => Array ( [und] => Array ( [0] => Array ( [value] => 2020-12-03T00:00:00 [value2] => 2021-04-03T00:00:00 [timezone] => Europe/Paris [timezone_db] => Europe/Paris [date_type] => date ) ) ) [field_layout_news] => Array ( [und] => Array ( [0] => Array ( [value] => single ) ) ) [field_testo_opzionale_news] => Array ( ) [field_url_en_page] => Array ( ) [field_url_en_page_label] => Array ( ) [path] => Array ( [pathauto] => 1 ) [name] => francesca.forzan [picture] => 0 [data] => b:0; [num_revisions] => 6 [current_revision_id] => 340899 [is_current] => 1 [is_pending] => [revision_moderation] => [entity_view_prepared] => 1 ) [#items] => Array ( [0] => Array ( [value] => 2020-12-03T00:00:00 [timezone] => Europe/Paris [timezone_db] => Europe/Paris [date_type] => date ) ) [#formatter] => date_default [0] => Array ( [#markup] => Gio, 03/12/2020 ) ) )

2019N73 - Quesiti prove scritte

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Quesiti prove scritte [href] => node/73589 [html] => 1 [attributes] => Array ( [rel] => tag [title] => 2019N73 - Quesiti prove scritte ) ) ) [#attributes] => Array ( [class] => Array ( [0] => links [1] => inline ) ) ) ) )

2019N73 - Criteri di valutazione

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2019N73.pdf [uri] => public://2023/Criteri di valutazione - 2019N73.pdf [filemime] => application/pdf [filesize] => 238706 [status] => 1 [timestamp] => 1675165858 [type] => document [field_folder] => Array ( [und] => Array ( [0] => Array ( [tid] => 2529 ) ) ) [metadata] => Array ( ) [display] => 1 [description] => ) ) [#formatter] => file_default [0] => Array ( [#theme] => file_link [#file] => stdClass Object ( [fid] => 115313 [uid] => 32 [filename] => Criteri di valutazione - 2019N73.pdf [uri] => public://2023/Criteri di valutazione - 2019N73.pdf [filemime] => application/pdf [filesize] => 238706 [status] => 1 [timestamp] => 1675165858 [type] => document [field_folder] => Array ( [und] => Array ( [0] => Array ( [tid] => 2529 ) ) ) [metadata] => Array ( ) [display] => 1 [description] => ) ) ) [links] => Array ( [#theme] => links__node [#pre_render] => Array ( [0] => drupal_pre_render_links ) [#attributes] => Array ( [class] => Array ( [0] => links [1] => inline ) ) [node] => Array ( [#theme] => links__node__node [#links] => Array ( [node-readmore] => Array ( [title] => Read more about 2019N73 - Criteri di valutazione [href] => node/73588 [html] => 1 [attributes] => Array ( [rel] => tag [title] => 2019N73 - Criteri di valutazione ) ) ) [#attributes] => Array ( [class] => Array ( [0] => links [1] => inline ) ) ) ) )

2019N73 - criteri di valutazione

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criteri di valutazione [href] => node/73587 [html] => 1 [attributes] => Array ( [rel] => tag [title] => 2019N73 - criteri di valutazione ) ) ) [#attributes] => Array ( [class] => Array ( [0] => links [1] => inline ) ) ) ) )

Servizi online

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Risorse e servizi online dell'Università di Padova


SERVIZI 

Orari Unipd (app per gestire l'orario delle lezioni, appelli d'esame e registrazione presenza alle lezioni)
Affluences (app per chi frequenta le biblioteche)
Simulatore tasse (Simulatore calcolo contributi)
Easy staff (Orario lezioni, appelli d’esame, aule .. )
Tutte le App di Unipd (Orari, Myunipd. Studiare a Padova, Affluences. Career service) 
Piattaforme Moodle di Ateneo  (Moodle dei Dipartimeni e delle Scuole di Ateneo)
Massive Open Online Courses (MOOC corsi online gratuiti) 


PROCEDURE 

Procedure online per la richiesta di servizi o partecipazione a iniziative

Uniweb
Richiesta di agevolazione, iscrizioni ai bandi di tutorato,  iscrizione corsi a Bressanone, opzione scelta per mille e una lode

Studenti a regime parziale
Doppia carriera studente atleta (chiusa) 
Iniziative culturali e progetti innovativi (chiusa) 


PRENOTAZIONI

Prenotazione consulenze e servizi con gli Uffici

Servizi studenti
Benefici economici
Inclusione
Orientamento e tutorato
Incontri individuali di orientamento e ri-orientamento
Altre iniziative di orientamento

Carriere studenti
Consulenza generica
Gestione carriera 


RISORSE DELLE BIBLIOTECHE 

Biblioteca digitale
Connessione da remoto eduVPN
Collezioni digitali
Mostre virtuali


[summary] => [format] => 2 [safe_value] =>

Risorse e servizi online dell'Università di Padova


SERVIZI 

Orari Unipd (app per gestire l'orario delle lezioni, appelli d'esame e registrazione presenza alle lezioni)
Affluences (app per chi frequenta le biblioteche)
Simulatore tasse (Simulatore calcolo contributi)
Easy staff (Orario lezioni, appelli d’esame, aule .. )
Tutte le App di Unipd (Orari, Myunipd. Studiare a Padova, Affluences. Career service) 
Piattaforme Moodle di Ateneo  (Moodle dei Dipartimeni e delle Scuole di Ateneo)
Massive Open Online Courses (MOOC corsi online gratuiti) 


PROCEDURE 

Procedure online per la richiesta di servizi o partecipazione a iniziative

Uniweb
Richiesta di agevolazione, iscrizioni ai bandi di tutorato,  iscrizione corsi a Bressanone, opzione scelta per mille e una lode

Studenti a regime parziale
Doppia carriera studente atleta (chiusa) 
Iniziative culturali e progetti innovativi (chiusa) 


PRENOTAZIONI

Prenotazione consulenze e servizi con gli Uffici

Servizi studenti
Benefici economici
Inclusione
Orientamento e tutorato
Incontri individuali di orientamento e ri-orientamento
Altre iniziative di orientamento

Carriere studenti
Consulenza generica
Gestione carriera 


RISORSE DELLE BIBLIOTECHE 

Biblioteca digitale
Connessione da remoto eduVPN
Collezioni digitali
Mostre virtuali


[safe_summary] => ) ) ) [field_foglia_complessa_accordion] => Array ( ) [field_foglia_complessa_allegato] => Array ( ) [field_image_fc] => Array ( ) [field_testo_opzionale_fc] => Array ( ) [field_immagine_top] => Array ( ) [field_immagine_bottom] => Array ( ) [field_immagine_decorativa_latera] => Array ( [und] => Array ( [0] => Array ( [fid] => 60003 [uid] => 4 [filename] => bianco.jpg [uri] => public://bianco_1.jpg [filemime] => image/jpeg [filesize] => 884 [status] => 1 [timestamp] => 1634298206 [type] => image [field_file_image_alt_text] => Array ( [und] => Array ( [0] => Array ( [value] => Bianco laterale [format] => [safe_value] => Bianco laterale ) ) ) [field_file_image_title_text] => Array ( ) [field_folder] => Array ( [und] => Array ( [0] => Array ( [tid] => 2048 ) ) ) [metatags] => Array ( [und] => Array ( [title] => Array ( [value] => [current-page:title] | [current-page:pager][site:name] [default] => [current-page:title] | [current-page:pager][site:name] ) [description] => Array ( [value] => ) [abstract] => Array ( [value] => ) [keywords] => Array ( [value] => ) [robots] => Array ( [value] => Array ( [index] => 0 [follow] => 0 [noindex] => 0 [nofollow] => 0 [noarchive] => 0 [nosnippet] => 0 [noodp] => 0 [noydir] => 0 [noimageindex] => 0 [notranslate] => 0 ) ) [news_keywords] => Array ( [value] => ) [standout] => Array ( [value] => ) [rating] => Array ( [value] => ) [referrer] => Array ( [value] => ) [rights] => Array ( [value] => ) [image_src] => Array ( [value] => ) [canonical] => Array ( [value] => [current-page:url:absolute] [default] => [current-page:url:absolute] ) [set_cookie] => Array ( [value] => ) [shortlink] => Array ( [value] => [current-page:url:unaliased] [default] => [current-page:url:unaliased] ) [original-source] => Array ( [value] => ) [prev] => Array ( [value] => ) [next] => Array ( [value] => ) [content-language] => Array ( [value] => ) [geo.position] => Array ( [value] => ) [geo.placename] => Array ( [value] => ) [geo.region] => Array ( [value] => ) [icbm] => Array ( [value] => ) [refresh] => Array ( [value] => ) [revisit-after] => Array ( [value] => [period] => ) [pragma] => Array ( [value] => ) [cache-control] => Array ( [value] => ) [expires] => Array ( [value] => ) [og:type] => Array ( [value] => article [default] => article ) [og:url] => Array ( [value] => [current-page:url:absolute] [default] => [current-page:url:absolute] ) [og:title] => Array ( [value] => [current-page:title] [default] => [current-page:title] ) [og:determiner] => Array ( [value] => ) [og:description] => Array ( [value] => ) [og:updated_time] => Array ( [value] => ) [og:see_also] => Array ( [value] => ) [og:image] => Array ( [value] => ) [og:image:url] => Array ( [value] => ) [og:image:secure_url] => Array ( [value] => ) [og:image:type] => Array ( [value] => ) [og:image:width] => Array ( [value] => ) [og:image:height] => Array ( [value] => ) [og:latitude] => Array ( [value] => ) [og:longitude] => Array ( [value] => ) [og:street_address] => Array ( [value] => ) [og:locality] => Array ( [value] => ) [og:region] => Array ( [value] => ) [og:postal_code] => Array ( [value] => ) [og:country_name] => Array ( [value] => ) [og:email] => Array ( [value] => ) [og:phone_number] => Array ( [value] => ) [og:fax_number] => Array ( [value] => ) [og:locale] => Array ( [value] => ) [og:locale:alternate] => Array ( [value] => ) [article:author] => Array ( [value] => ) [article:publisher] => Array ( [value] => ) [article:section] => Array ( [value] => ) [article:tag] => Array ( [value] => ) [article:published_time] => Array ( [value] => ) [article:modified_time] => Array ( [value] => ) [article:expiration_time] => Array ( [value] => ) [profile:first_name] => Array ( [value] => ) [profile:last_name] => Array ( [value] => ) [profile:username] => Array ( [value] => ) [profile:gender] => Array ( [value] => ) [og:audio] => Array ( [value] => ) [og:audio:secure_url] => Array ( [value] => ) [og:audio:type] => Array ( [value] => ) [book:author] => Array ( [value] => ) [book:isbn] => Array ( [value] => ) [book:release_date] => Array ( [value] => ) [book:tag] => Array ( [value] => ) [og:video:url] => Array ( [value] => ) [og:video:secure_url] => Array ( [value] => ) [og:video:width] => Array ( [value] => ) [og:video:height] => Array ( [value] => ) [og:video:type] => Array ( [value] => ) [video:actor] => Array ( [value] => ) [video:actor:role] => Array ( [value] => ) [video:director] => Array ( [value] => ) [video:writer] => Array ( [value] => ) [video:duration] => Array ( [value] => ) [video:release_date] => Array ( [value] => ) [video:tag] => Array ( [value] => ) [video:series] => Array ( [value] => ) ) ) [alt] => Bianco laterale [metadata] => Array ( [height] => 100 [width] => 100 ) [height] => 100 [width] => 100 [title] => ) ) ) [field_link_in_evidenza] => Array ( ) [field_usa_layout_pagina_link] => Array ( [und] => Array ( [0] => Array ( [value] => 0 ) ) ) [field_etichetta_link_in_evidenza] => Array ( ) [field_tabs] => Array ( ) [field_condividi_social] => Array ( [und] => Array ( [0] => Array ( [value] => 0 ) ) ) [field_formato_immagine] => Array ( ) [field_video_link] => Array ( ) [field_nosidebar] => Array ( [und] => Array ( [0] => Array ( [value] => 0 ) ) ) [field_chatbot] => Array ( [und] => Array ( [0] => Array ( [value] => 0 ) ) ) [field_chatbot_codice_chat] => Array ( ) [field_header_custom] => Array ( [und] => Array ( [0] => Array ( [value] => 0 ) ) ) [field_header_custom_ref] => Array ( ) [field_accessiway] => Array ( [und] => Array ( [0] => Array ( [value] => 0 ) ) ) [field_footer_custom] => Array ( [und] => Array ( [0] => Array ( [value] => 0 ) ) ) [field_footer_custom_ref] => Array ( ) [field_usa_layout_hero] => Array ( [und] => Array ( [0] => Array ( [value] => 0 ) ) ) [field_note_interne] => Array ( ) [field_url_en_page] => Array ( ) [field_crawler_ai] => Array ( ) [path] => Array ( [pathauto] => 0 ) [name] => simonetta.admin [picture] => 0 [data] => b:0; [num_revisions] => 25 [current_revision_id] => 516417 [is_current] => 1 [is_pending] => [revision_moderation] => [entity_view_prepared] => 1 ) [#items] => Array ( [0] => Array ( [value] =>

Risorse e servizi online dell'Università di Padova


SERVIZI 

Orari Unipd (app per gestire l'orario delle lezioni, appelli d'esame e registrazione presenza alle lezioni)
Affluences (app per chi frequenta le biblioteche)
Simulatore tasse (Simulatore calcolo contributi)
Easy staff (Orario lezioni, appelli d’esame, aule .. )
Tutte le App di Unipd (Orari, Myunipd. Studiare a Padova, Affluences. Career service) 
Piattaforme Moodle di Ateneo  (Moodle dei Dipartimeni e delle Scuole di Ateneo)
Massive Open Online Courses (MOOC corsi online gratuiti) 


PROCEDURE 

Procedure online per la richiesta di servizi o partecipazione a iniziative

Uniweb
Richiesta di agevolazione, iscrizioni ai bandi di tutorato,  iscrizione corsi a Bressanone, opzione scelta per mille e una lode

Studenti a regime parziale
Doppia carriera studente atleta (chiusa) 
Iniziative culturali e progetti innovativi (chiusa) 


PRENOTAZIONI

Prenotazione consulenze e servizi con gli Uffici

Servizi studenti
Benefici economici
Inclusione
Orientamento e tutorato
Incontri individuali di orientamento e ri-orientamento
Altre iniziative di orientamento

Carriere studenti
Consulenza generica
Gestione carriera 


RISORSE DELLE BIBLIOTECHE 

Biblioteca digitale
Connessione da remoto eduVPN
Collezioni digitali
Mostre virtuali


[summary] => [format] => 2 [safe_value] =>

Risorse e servizi online dell'Università di Padova


SERVIZI 

Orari Unipd (app per gestire l'orario delle lezioni, appelli d'esame e registrazione presenza alle lezioni)
Affluences (app per chi frequenta le biblioteche)
Simulatore tasse (Simulatore calcolo contributi)
Easy staff (Orario lezioni, appelli d’esame, aule .. )
Tutte le App di Unipd (Orari, Myunipd. Studiare a Padova, Affluences. Career service) 
Piattaforme Moodle di Ateneo  (Moodle dei Dipartimeni e delle Scuole di Ateneo)
Massive Open Online Courses (MOOC corsi online gratuiti) 


PROCEDURE 

Procedure online per la richiesta di servizi o partecipazione a iniziative

Uniweb
Richiesta di agevolazione, iscrizioni ai bandi di tutorato,  iscrizione corsi a Bressanone, opzione scelta per mille e una lode

Studenti a regime parziale
Doppia carriera studente atleta (chiusa) 
Iniziative culturali e progetti innovativi (chiusa) 


PRENOTAZIONI

Prenotazione consulenze e servizi con gli Uffici

Servizi studenti
Benefici economici
Inclusione
Orientamento e tutorato
Incontri individuali di orientamento e ri-orientamento
Altre iniziative di orientamento

Carriere studenti
Consulenza generica
Gestione carriera 


RISORSE DELLE BIBLIOTECHE 

Biblioteca digitale
Connessione da remoto eduVPN
Collezioni digitali
Mostre virtuali


[safe_summary] => ) ) [#formatter] => text_summary_or_trimmed [0] => Array ( [#markup] =>

Risorse e servizi online dell'Università di Padova

) ) [links] => Array ( [#theme] => links__node [#pre_render] => Array ( [0] => drupal_pre_render_links ) [#attributes] => Array ( [class] => Array ( [0] => links [1] => inline ) ) [node] => Array ( [#theme] => links__node__node [#links] => Array ( [node-readmore] => Array ( [title] => Read more about Servizi online [href] => node/73586 [html] => 1 [attributes] => Array ( [rel] => tag [title] => Servizi online ) ) ) [#attributes] => Array ( [class] => Array ( [0] => links [1] => inline ) ) ) ) [taxonomy_vocabulary_3] => Array ( [#theme] => field [#weight] => 10 [#title] => target [#access] => 1 [#label_display] => above [#view_mode] => teaser [#language] => und [#field_name] => taxonomy_vocabulary_3 [#field_type] => taxonomy_term_reference [#field_translatable] => 0 [#entity_type] => node [#bundle] => foglia_complessa [#object] => stdClass Object ( [vid] => 516417 [uid] => 102 [title] => Servizi online [log] => [status] => 1 [comment] => 0 [promote] => 1 [sticky] => 0 [nid] => 73586 [type] => foglia_complessa [language] => it [created] => 1606986686 [changed] => 1769414234 [tnid] => 0 [translate] => 0 [revision_timestamp] => 1769414234 [revision_uid] => 4 [taxonomy_vocabulary_2] => Array ( ) [taxonomy_vocabulary_3] => Array ( [und] => Array ( [0] => Array ( [tid] => 2110 [taxonomy_term] => stdClass Object ( [tid] => 2110 [vid] => 3 [name] => L'Università e la città [description] => [format] => 1 [weight] => 7 [vocabulary_machine_name] => vocabulary_3 [field_image] => Array ( [und] => Array ( [0] => Array ( [fid] => 53497 [uid] => 17 [filename] => vivere_padova.jpg [uri] => public://vivere_padova.jpg [filemime] => image/jpeg [filesize] => 482847 [status] => 1 [timestamp] => 1498223922 [type] => image [field_file_image_alt_text] => Array ( ) [field_file_image_title_text] => Array ( ) [field_folder] => Array ( [und] => Array ( [0] => Array ( [tid] => 2048 ) ) ) [metadata] => Array ( [height] => 375 [width] => 980 ) [height] => 375 [width] => 980 [alt] => [title] => ) ) ) [field_classe_icona] => Array ( [und] => Array ( [0] => Array ( [value] => icon-vivere_a_padova [format] => [safe_value] => icon-vivere_a_padova ) ) ) [field_lancio_griglia_target] => Array ( ) [field_lancio_area_target] => Array ( ) [field_lancio_news_target] => Array ( ) [field_altre_news_link] => Array ( ) [field_altre_news_etichetta] => Array ( ) [path] => Array ( [pathauto] => 0 ) ) ) ) ) [taxonomy_vocabulary_8] => Array ( ) [body] => Array ( [und] => Array ( [0] => Array ( [value] =>

Risorse e servizi online dell'Università di Padova


SERVIZI 

Orari Unipd (app per gestire l'orario delle lezioni, appelli d'esame e registrazione presenza alle lezioni)
Affluences (app per chi frequenta le biblioteche)
Simulatore tasse (Simulatore calcolo contributi)
Easy staff (Orario lezioni, appelli d’esame, aule .. )
Tutte le App di Unipd (Orari, Myunipd. Studiare a Padova, Affluences. Career service) 
Piattaforme Moodle di Ateneo  (Moodle dei Dipartimeni e delle Scuole di Ateneo)
Massive Open Online Courses (MOOC corsi online gratuiti) 


PROCEDURE 

Procedure online per la richiesta di servizi o partecipazione a iniziative

Uniweb
Richiesta di agevolazione, iscrizioni ai bandi di tutorato,  iscrizione corsi a Bressanone, opzione scelta per mille e una lode

Studenti a regime parziale
Doppia carriera studente atleta (chiusa) 
Iniziative culturali e progetti innovativi (chiusa) 


PRENOTAZIONI

Prenotazione consulenze e servizi con gli Uffici

Servizi studenti
Benefici economici
Inclusione
Orientamento e tutorato
Incontri individuali di orientamento e ri-orientamento
Altre iniziative di orientamento

Carriere studenti
Consulenza generica
Gestione carriera 


RISORSE DELLE BIBLIOTECHE 

Biblioteca digitale
Connessione da remoto eduVPN
Collezioni digitali
Mostre virtuali


[summary] => [format] => 2 [safe_value] =>

Risorse e servizi online dell'Università di Padova


SERVIZI 

Orari Unipd (app per gestire l'orario delle lezioni, appelli d'esame e registrazione presenza alle lezioni)
Affluences (app per chi frequenta le biblioteche)
Simulatore tasse (Simulatore calcolo contributi)
Easy staff (Orario lezioni, appelli d’esame, aule .. )
Tutte le App di Unipd (Orari, Myunipd. Studiare a Padova, Affluences. Career service) 
Piattaforme Moodle di Ateneo  (Moodle dei Dipartimeni e delle Scuole di Ateneo)
Massive Open Online Courses (MOOC corsi online gratuiti) 


PROCEDURE 

Procedure online per la richiesta di servizi o partecipazione a iniziative

Uniweb
Richiesta di agevolazione, iscrizioni ai bandi di tutorato,  iscrizione corsi a Bressanone, opzione scelta per mille e una lode

Studenti a regime parziale
Doppia carriera studente atleta (chiusa) 
Iniziative culturali e progetti innovativi (chiusa) 


PRENOTAZIONI

Prenotazione consulenze e servizi con gli Uffici

Servizi studenti
Benefici economici
Inclusione
Orientamento e tutorato
Incontri individuali di orientamento e ri-orientamento
Altre iniziative di orientamento

Carriere studenti
Consulenza generica
Gestione carriera 


RISORSE DELLE BIBLIOTECHE 

Biblioteca digitale
Connessione da remoto eduVPN
Collezioni digitali
Mostre virtuali


[safe_summary] => ) ) ) [field_foglia_complessa_accordion] => Array ( ) [field_foglia_complessa_allegato] => Array ( ) [field_image_fc] => Array ( ) [field_testo_opzionale_fc] => Array ( ) [field_immagine_top] => Array ( ) [field_immagine_bottom] => Array ( ) [field_immagine_decorativa_latera] => Array ( [und] => Array ( [0] => Array ( [fid] => 60003 [uid] => 4 [filename] => bianco.jpg [uri] => public://bianco_1.jpg [filemime] => image/jpeg [filesize] => 884 [status] => 1 [timestamp] => 1634298206 [type] => image [field_file_image_alt_text] => Array ( [und] => Array ( [0] => Array ( [value] => Bianco laterale [format] => [safe_value] => Bianco laterale ) ) ) [field_file_image_title_text] => Array ( ) [field_folder] => Array ( [und] => Array ( [0] => Array ( [tid] => 2048 ) ) ) [metatags] => Array ( [und] => Array ( [title] => Array ( [value] => [current-page:title] | [current-page:pager][site:name] [default] => [current-page:title] | [current-page:pager][site:name] ) [description] => Array ( [value] => ) [abstract] => Array ( [value] => ) [keywords] => Array ( [value] => ) [robots] => Array ( [value] => Array ( [index] => 0 [follow] => 0 [noindex] => 0 [nofollow] => 0 [noarchive] => 0 [nosnippet] => 0 [noodp] => 0 [noydir] => 0 [noimageindex] => 0 [notranslate] => 0 ) ) [news_keywords] => Array ( [value] => ) [standout] => Array ( [value] => ) [rating] => Array ( [value] => ) [referrer] => Array ( [value] => ) [rights] => Array ( [value] => ) [image_src] => Array ( [value] => ) [canonical] => Array ( [value] => [current-page:url:absolute] [default] => [current-page:url:absolute] ) [set_cookie] => Array ( [value] => ) [shortlink] => Array ( [value] => [current-page:url:unaliased] [default] => [current-page:url:unaliased] ) [original-source] => Array ( [value] => ) [prev] => Array ( [value] => ) [next] => Array ( [value] => ) [content-language] => Array ( [value] => ) [geo.position] => Array ( [value] => ) [geo.placename] => Array ( [value] => ) [geo.region] => Array ( [value] => ) [icbm] => Array ( [value] => ) [refresh] => Array ( [value] => ) [revisit-after] => Array ( [value] => [period] => ) [pragma] => Array ( [value] => ) [cache-control] => Array ( [value] => ) [expires] => Array ( [value] => ) [og:type] => Array ( [value] => article [default] => article ) [og:url] => Array ( [value] => [current-page:url:absolute] [default] => [current-page:url:absolute] ) [og:title] => Array ( [value] => [current-page:title] [default] => [current-page:title] ) [og:determiner] => Array ( [value] => ) [og:description] => Array ( [value] => ) [og:updated_time] => Array ( [value] => ) [og:see_also] => Array ( [value] => ) [og:image] => Array ( [value] => ) [og:image:url] => Array ( [value] => ) [og:image:secure_url] => Array ( [value] => ) [og:image:type] => Array ( [value] => ) [og:image:width] => Array ( [value] => ) [og:image:height] => Array ( [value] => ) [og:latitude] => Array ( [value] => ) [og:longitude] => Array ( [value] => ) [og:street_address] => Array ( [value] => ) [og:locality] => Array ( [value] => ) [og:region] => Array ( [value] => ) [og:postal_code] => Array ( [value] => ) [og:country_name] => Array ( [value] => ) [og:email] => Array ( [value] => ) [og:phone_number] => Array ( [value] => ) [og:fax_number] => Array ( [value] => ) [og:locale] => Array ( [value] => ) [og:locale:alternate] => Array ( [value] => ) [article:author] => Array ( [value] => ) [article:publisher] => Array ( [value] => ) [article:section] => Array ( [value] => ) [article:tag] => Array ( [value] => ) [article:published_time] => Array ( [value] => ) [article:modified_time] => Array ( [value] => ) [article:expiration_time] => Array ( [value] => ) [profile:first_name] => Array ( [value] => ) [profile:last_name] => Array ( [value] => ) [profile:username] => Array ( [value] => ) [profile:gender] => Array ( [value] => ) [og:audio] => Array ( [value] => ) [og:audio:secure_url] => Array ( [value] => ) [og:audio:type] => Array ( [value] => ) [book:author] => Array ( [value] => ) [book:isbn] => Array ( [value] => ) [book:release_date] => Array ( [value] => ) [book:tag] => Array ( [value] => ) [og:video:url] => Array ( [value] => ) [og:video:secure_url] => Array ( [value] => ) [og:video:width] => Array ( [value] => ) [og:video:height] => Array ( [value] => ) [og:video:type] => Array ( [value] => ) [video:actor] => Array ( [value] => ) [video:actor:role] => Array ( [value] => ) [video:director] => Array ( [value] => ) [video:writer] => Array ( [value] => ) [video:duration] => Array ( [value] => ) [video:release_date] => Array ( [value] => ) [video:tag] => Array ( [value] => ) [video:series] => Array ( [value] => ) ) ) [alt] => Bianco laterale [metadata] => Array ( [height] => 100 [width] => 100 ) [height] => 100 [width] => 100 [title] => ) ) ) [field_link_in_evidenza] => Array ( ) [field_usa_layout_pagina_link] => Array ( [und] => Array ( [0] => Array ( [value] => 0 ) ) ) [field_etichetta_link_in_evidenza] => Array ( ) [field_tabs] => Array ( ) [field_condividi_social] => Array ( [und] => Array ( [0] => Array ( [value] => 0 ) ) ) [field_formato_immagine] => Array ( ) [field_video_link] => Array ( ) [field_nosidebar] => Array ( [und] => Array ( [0] => Array ( [value] => 0 ) ) ) [field_chatbot] => Array ( [und] => Array ( [0] => Array ( [value] => 0 ) ) ) [field_chatbot_codice_chat] => Array ( ) [field_header_custom] => Array ( [und] => Array ( [0] => Array ( [value] => 0 ) ) ) [field_header_custom_ref] => Array ( ) [field_accessiway] => Array ( [und] => Array ( [0] => Array ( [value] => 0 ) ) ) [field_footer_custom] => Array ( [und] => Array ( [0] => Array ( [value] => 0 ) ) ) [field_footer_custom_ref] => Array ( ) [field_usa_layout_hero] => Array ( [und] => Array ( [0] => Array ( [value] => 0 ) ) ) [field_note_interne] => Array ( ) [field_url_en_page] => Array ( ) [field_crawler_ai] => Array ( ) [path] => Array ( [pathauto] => 0 ) [name] => simonetta.admin [picture] => 0 [data] => b:0; [num_revisions] => 25 [current_revision_id] => 516417 [is_current] => 1 [is_pending] => [revision_moderation] => [entity_view_prepared] => 1 ) [#items] => Array ( [0] => Array ( [tid] => 2110 [taxonomy_term] => stdClass Object ( [tid] => 2110 [vid] => 3 [name] => L'Università e la città [description] => [format] => 1 [weight] => 7 [vocabulary_machine_name] => vocabulary_3 [field_image] => Array ( [und] => Array ( [0] => Array ( [fid] => 53497 [uid] => 17 [filename] => vivere_padova.jpg [uri] => public://vivere_padova.jpg [filemime] => image/jpeg [filesize] => 482847 [status] => 1 [timestamp] => 1498223922 [type] => image [field_file_image_alt_text] => Array ( ) [field_file_image_title_text] => Array ( ) [field_folder] => Array ( [und] => Array ( [0] => Array ( [tid] => 2048 ) ) ) [metadata] => Array ( [height] => 375 [width] => 980 ) [height] => 375 [width] => 980 [alt] => [title] => ) ) ) [field_classe_icona] => Array ( [und] => Array ( [0] => Array ( [value] => icon-vivere_a_padova [format] => 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Unipd studies the mechanism of action between antiviral drugs and the SARS-CoV-2 main protease

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Identifying a new drug is a timely and complex process, taking an average of ten years to complete, and includes substantial economic resources and various transversal scientific skills. Reducing the amount of time needed to identify a new drug, especially in a scenario such as the current Covid-19 pandemic, would be enormously beneficial. Recent developments in information technology together with advances in pharmaceutical chemistry have led to "simulating the entire recognition process between a drug and its molecular target." As such, using an accurate virtual replication, the goal is to precisely understand what happens in the human body and then translate results into therapeutic action.

The Molecular Modeling Section (MMS) of the Department of Pharmaceutical and Pharmacological Sciences at the University of Padua has developed, under a reasonable timeline and with a high level of accuracy, a methodology that follows the path of a drug as it encounters and recognizes a particular region of a molecular target in order for it to perform its function.

Led by Prof Stefano Moro and his team from the Department of Pharmaceutical and Pharmacological Sciences, the work published in "Scientific Reports" is based on the mechanism of action of a drug at the molecular level and entitled, Targeting the coronavirus SARS-CoV-2: computational insights into the mechanism of action of the protease inhibitors lopinavir, ritonavir and nelfinavir (Giovanni Bolcato, Maicol Bissaro, Matteo Pavan, Mattia Sturlese, & Stefano Moro).

To date, no molecular details are available regarding the mechanism of action of antiviral drugs that support a clinical use to fight the Covid-19 emergency. Historically, the treatment strategy is to use previous clinical evidence to prove effectiveness in other pathologies and then apply this under new contexts during a pandemic. Pre-approved pharmacological treatments for other viral infections were used against the virus during the first wave of the SARS-CoV-2 emergency, setting a base for the treatment of Covid-19. Taking advantage of evidence discovered during the first coronavirus pandemic (SARS, 2002-2003), doctors have adopted a therapeutic approach using HIV antiretroviral drugs. Doctors gathered the positive preliminary indications on the effectiveness of the treatment while waiting for an effective vaccine.

Prof. Stefano Moro explains, "The particular technique that was developed in our laboratory is called supervised molecular dynamics (SuMD). This technique has found its application, in the midst of the SARS-CoV-2 coronavirus pandemic, by describing the molecular recognition between the main protease Mpro, an important virus protein, and three drugs previously used in the clinical setting for the pathological treatment of viral infections. Of the three drugs used, the molecular description of their mechanism of action with the Mpro protease was still unknown.” This technique allows us to follow how the drug approaches its target protein over time, as well as in which region the surface recognition occurs, and what recognizable chemical property of the drug carries out its success.

PhD students Giovanni Bolcato and Maicol Bissaro from MMS of the Department of Pharmaceutical and Pharmacological Sciences explain, “In addition to interpreting, at an atomic level, the mechanism recognized between the three drugs (Lopinavir, Ritonavir and Nelfinavir) and where the Mpro protease takes place, the application of this methodology lays the foundations for a new phase of potential drug designs for the same viral protein and other proteins needed during the SARS-CoV-2 replication cycle. This computational technique allows us to suggest new chemical structures that present better therapeutic efficacy as well as reducing possible side effects on the body. The main result of using this methodology will be to support experimental studies in identifying the early stage of all the possible drug candidates and the optimal characteristics for an efficient recognition of the molecular target. Not only that, it will be possible to decrease the number of chemical compounds needed to introduce into the supply chain for the development of a new drug, consequently reducing time and costs. Finally, it will be possible to have preliminary, yet accurate, indications of the potential toxicity profile of these drugs by applying the same methodology to the proteins that should not be simultaneously recognized by the same compound and which must therefore maintain their functionality even during the start and during the development of the disease."

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Identifying a new drug is a timely and complex process, taking an average of ten years to complete, and includes substantial economic resources and various transversal scientific skills. Reducing the amount of time needed to identify a new drug, especially in a scenario such as the current Covid-19 pandemic, would be enormously beneficial. Recent developments in information technology together with advances in pharmaceutical chemistry have led to "simulating the entire recognition process between a drug and its molecular target." As such, using an accurate virtual replication, the goal is to precisely understand what happens in the human body and then translate results into therapeutic action.

The Molecular Modeling Section (MMS) of the Department of Pharmaceutical and Pharmacological Sciences at the University of Padua has developed, under a reasonable timeline and with a high level of accuracy, a methodology that follows the path of a drug as it encounters and recognizes a particular region of a molecular target in order for it to perform its function.

Led by Prof Stefano Moro and his team from the Department of Pharmaceutical and Pharmacological Sciences, the work published in "Scientific Reports" is based on the mechanism of action of a drug at the molecular level and entitled, Targeting the coronavirus SARS-CoV-2: computational insights into the mechanism of action of the protease inhibitors lopinavir, ritonavir and nelfinavir (Giovanni Bolcato, Maicol Bissaro, Matteo Pavan, Mattia Sturlese, & Stefano Moro).

To date, no molecular details are available regarding the mechanism of action of antiviral drugs that support a clinical use to fight the Covid-19 emergency. Historically, the treatment strategy is to use previous clinical evidence to prove effectiveness in other pathologies and then apply this under new contexts during a pandemic. Pre-approved pharmacological treatments for other viral infections were used against the virus during the first wave of the SARS-CoV-2 emergency, setting a base for the treatment of Covid-19. Taking advantage of evidence discovered during the first coronavirus pandemic (SARS, 2002-2003), doctors have adopted a therapeutic approach using HIV antiretroviral drugs. Doctors gathered the positive preliminary indications on the effectiveness of the treatment while waiting for an effective vaccine.

Prof. Stefano Moro explains, "The particular technique that was developed in our laboratory is called supervised molecular dynamics (SuMD). This technique has found its application, in the midst of the SARS-CoV-2 coronavirus pandemic, by describing the molecular recognition between the main protease Mpro, an important virus protein, and three drugs previously used in the clinical setting for the pathological treatment of viral infections. Of the three drugs used, the molecular description of their mechanism of action with the Mpro protease was still unknown.” This technique allows us to follow how the drug approaches its target protein over time, as well as in which region the surface recognition occurs, and what recognizable chemical property of the drug carries out its success.

PhD students Giovanni Bolcato and Maicol Bissaro from MMS of the Department of Pharmaceutical and Pharmacological Sciences explain, “In addition to interpreting, at an atomic level, the mechanism recognized between the three drugs (Lopinavir, Ritonavir and Nelfinavir) and where the Mpro protease takes place, the application of this methodology lays the foundations for a new phase of potential drug designs for the same viral protein and other proteins needed during the SARS-CoV-2 replication cycle. This computational technique allows us to suggest new chemical structures that present better therapeutic efficacy as well as reducing possible side effects on the body. The main result of using this methodology will be to support experimental studies in identifying the early stage of all the possible drug candidates and the optimal characteristics for an efficient recognition of the molecular target. Not only that, it will be possible to decrease the number of chemical compounds needed to introduce into the supply chain for the development of a new drug, consequently reducing time and costs. Finally, it will be possible to have preliminary, yet accurate, indications of the potential toxicity profile of these drugs by applying the same methodology to the proteins that should not be simultaneously recognized by the same compound and which must therefore maintain their functionality even during the start and during the development of the disease."

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Identifying a new drug is a timely and complex process, taking an average of ten years to complete, and includes substantial economic resources and various transversal scientific skills. Reducing the amount of time needed to identify a new drug, especially in a scenario such as the current Covid-19 pandemic, would be enormously beneficial. Recent developments in information technology together with advances in pharmaceutical chemistry have led to "simulating the entire recognition process between a drug and its molecular target." As such, using an accurate virtual replication, the goal is to precisely understand what happens in the human body and then translate results into therapeutic action.

The Molecular Modeling Section (MMS) of the Department of Pharmaceutical and Pharmacological Sciences at the University of Padua has developed, under a reasonable timeline and with a high level of accuracy, a methodology that follows the path of a drug as it encounters and recognizes a particular region of a molecular target in order for it to perform its function.

Led by Prof Stefano Moro and his team from the Department of Pharmaceutical and Pharmacological Sciences, the work published in "Scientific Reports" is based on the mechanism of action of a drug at the molecular level and entitled, Targeting the coronavirus SARS-CoV-2: computational insights into the mechanism of action of the protease inhibitors lopinavir, ritonavir and nelfinavir (Giovanni Bolcato, Maicol Bissaro, Matteo Pavan, Mattia Sturlese, & Stefano Moro).

To date, no molecular details are available regarding the mechanism of action of antiviral drugs that support a clinical use to fight the Covid-19 emergency. Historically, the treatment strategy is to use previous clinical evidence to prove effectiveness in other pathologies and then apply this under new contexts during a pandemic. Pre-approved pharmacological treatments for other viral infections were used against the virus during the first wave of the SARS-CoV-2 emergency, setting a base for the treatment of Covid-19. Taking advantage of evidence discovered during the first coronavirus pandemic (SARS, 2002-2003), doctors have adopted a therapeutic approach using HIV antiretroviral drugs. Doctors gathered the positive preliminary indications on the effectiveness of the treatment while waiting for an effective vaccine.

Prof. Stefano Moro explains, "The particular technique that was developed in our laboratory is called supervised molecular dynamics (SuMD). This technique has found its application, in the midst of the SARS-CoV-2 coronavirus pandemic, by describing the molecular recognition between the main protease Mpro, an important virus protein, and three drugs previously used in the clinical setting for the pathological treatment of viral infections. Of the three drugs used, the molecular description of their mechanism of action with the Mpro protease was still unknown.” This technique allows us to follow how the drug approaches its target protein over time, as well as in which region the surface recognition occurs, and what recognizable chemical property of the drug carries out its success.

PhD students Giovanni Bolcato and Maicol Bissaro from MMS of the Department of Pharmaceutical and Pharmacological Sciences explain, “In addition to interpreting, at an atomic level, the mechanism recognized between the three drugs (Lopinavir, Ritonavir and Nelfinavir) and where the Mpro protease takes place, the application of this methodology lays the foundations for a new phase of potential drug designs for the same viral protein and other proteins needed during the SARS-CoV-2 replication cycle. This computational technique allows us to suggest new chemical structures that present better therapeutic efficacy as well as reducing possible side effects on the body. The main result of using this methodology will be to support experimental studies in identifying the early stage of all the possible drug candidates and the optimal characteristics for an efficient recognition of the molecular target. Not only that, it will be possible to decrease the number of chemical compounds needed to introduce into the supply chain for the development of a new drug, consequently reducing time and costs. Finally, it will be possible to have preliminary, yet accurate, indications of the potential toxicity profile of these drugs by applying the same methodology to the proteins that should not be simultaneously recognized by the same compound and which must therefore maintain their functionality even during the start and during the development of the disease."

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Identifying a new drug is a timely and complex process, taking an average of ten years to complete, and includes substantial economic resources and various transversal scientific skills. Reducing the amount of time needed to identify a new drug, especially in a scenario such as the current Covid-19 pandemic, would be enormously beneficial. Recent developments in information technology together with advances in pharmaceutical chemistry have led to "simulating the entire recognition process between a drug and its molecular target." As such, using an accurate virtual replication, the goal is to precisely understand what happens in the human body and then translate results into therapeutic action.

The Molecular Modeling Section (MMS) of the Department of Pharmaceutical and Pharmacological Sciences at the University of Padua has developed, under a reasonable timeline and with a high level of accuracy, a methodology that follows the path of a drug as it encounters and recognizes a particular region of a molecular target in order for it to perform its function.

Led by Prof Stefano Moro and his team from the Department of Pharmaceutical and Pharmacological Sciences, the work published in "Scientific Reports" is based on the mechanism of action of a drug at the molecular level and entitled, Targeting the coronavirus SARS-CoV-2: computational insights into the mechanism of action of the protease inhibitors lopinavir, ritonavir and nelfinavir (Giovanni Bolcato, Maicol Bissaro, Matteo Pavan, Mattia Sturlese, & Stefano Moro).

To date, no molecular details are available regarding the mechanism of action of antiviral drugs that support a clinical use to fight the Covid-19 emergency. Historically, the treatment strategy is to use previous clinical evidence to prove effectiveness in other pathologies and then apply this under new contexts during a pandemic. Pre-approved pharmacological treatments for other viral infections were used against the virus during the first wave of the SARS-CoV-2 emergency, setting a base for the treatment of Covid-19. Taking advantage of evidence discovered during the first coronavirus pandemic (SARS, 2002-2003), doctors have adopted a therapeutic approach using HIV antiretroviral drugs. Doctors gathered the positive preliminary indications on the effectiveness of the treatment while waiting for an effective vaccine.

Prof. Stefano Moro explains, "The particular technique that was developed in our laboratory is called supervised molecular dynamics (SuMD). This technique has found its application, in the midst of the SARS-CoV-2 coronavirus pandemic, by describing the molecular recognition between the main protease Mpro, an important virus protein, and three drugs previously used in the clinical setting for the pathological treatment of viral infections. Of the three drugs used, the molecular description of their mechanism of action with the Mpro protease was still unknown.” This technique allows us to follow how the drug approaches its target protein over time, as well as in which region the surface recognition occurs, and what recognizable chemical property of the drug carries out its success.

PhD students Giovanni Bolcato and Maicol Bissaro from MMS of the Department of Pharmaceutical and Pharmacological Sciences explain, “In addition to interpreting, at an atomic level, the mechanism recognized between the three drugs (Lopinavir, Ritonavir and Nelfinavir) and where the Mpro protease takes place, the application of this methodology lays the foundations for a new phase of potential drug designs for the same viral protein and other proteins needed during the SARS-CoV-2 replication cycle. This computational technique allows us to suggest new chemical structures that present better therapeutic efficacy as well as reducing possible side effects on the body. The main result of using this methodology will be to support experimental studies in identifying the early stage of all the possible drug candidates and the optimal characteristics for an efficient recognition of the molecular target. Not only that, it will be possible to decrease the number of chemical compounds needed to introduce into the supply chain for the development of a new drug, consequently reducing time and costs. Finally, it will be possible to have preliminary, yet accurate, indications of the potential toxicity profile of these drugs by applying the same methodology to the proteins that should not be simultaneously recognized by the same compound and which must therefore maintain their functionality even during the start and during the development of the disease."

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Identifying a new drug is a timely and complex process, taking an average of ten years to complete, and includes substantial economic resources and various transversal scientific skills. Reducing the amount of time needed to identify a new drug, especially in a scenario such as the current Covid-19 pandemic, would be enormously beneficial.

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Identifying a new drug is a timely and complex process, taking an average of ten years to complete, and includes substantial economic resources and various transversal scientific skills. Reducing the amount of time needed to identify a new drug, especially in a scenario such as the current Covid-19 pandemic, would be enormously beneficial. Recent developments in information technology together with advances in pharmaceutical chemistry have led to "simulating the entire recognition process between a drug and its molecular target." As such, using an accurate virtual replication, the goal is to precisely understand what happens in the human body and then translate results into therapeutic action.

The Molecular Modeling Section (MMS) of the Department of Pharmaceutical and Pharmacological Sciences at the University of Padua has developed, under a reasonable timeline and with a high level of accuracy, a methodology that follows the path of a drug as it encounters and recognizes a particular region of a molecular target in order for it to perform its function.

Led by Prof Stefano Moro and his team from the Department of Pharmaceutical and Pharmacological Sciences, the work published in "Scientific Reports" is based on the mechanism of action of a drug at the molecular level and entitled, Targeting the coronavirus SARS-CoV-2: computational insights into the mechanism of action of the protease inhibitors lopinavir, ritonavir and nelfinavir (Giovanni Bolcato, Maicol Bissaro, Matteo Pavan, Mattia Sturlese, & Stefano Moro).

To date, no molecular details are available regarding the mechanism of action of antiviral drugs that support a clinical use to fight the Covid-19 emergency. Historically, the treatment strategy is to use previous clinical evidence to prove effectiveness in other pathologies and then apply this under new contexts during a pandemic. Pre-approved pharmacological treatments for other viral infections were used against the virus during the first wave of the SARS-CoV-2 emergency, setting a base for the treatment of Covid-19. Taking advantage of evidence discovered during the first coronavirus pandemic (SARS, 2002-2003), doctors have adopted a therapeutic approach using HIV antiretroviral drugs. Doctors gathered the positive preliminary indications on the effectiveness of the treatment while waiting for an effective vaccine.

Prof. Stefano Moro explains, "The particular technique that was developed in our laboratory is called supervised molecular dynamics (SuMD). This technique has found its application, in the midst of the SARS-CoV-2 coronavirus pandemic, by describing the molecular recognition between the main protease Mpro, an important virus protein, and three drugs previously used in the clinical setting for the pathological treatment of viral infections. Of the three drugs used, the molecular description of their mechanism of action with the Mpro protease was still unknown.” This technique allows us to follow how the drug approaches its target protein over time, as well as in which region the surface recognition occurs, and what recognizable chemical property of the drug carries out its success.

PhD students Giovanni Bolcato and Maicol Bissaro from MMS of the Department of Pharmaceutical and Pharmacological Sciences explain, “In addition to interpreting, at an atomic level, the mechanism recognized between the three drugs (Lopinavir, Ritonavir and Nelfinavir) and where the Mpro protease takes place, the application of this methodology lays the foundations for a new phase of potential drug designs for the same viral protein and other proteins needed during the SARS-CoV-2 replication cycle. This computational technique allows us to suggest new chemical structures that present better therapeutic efficacy as well as reducing possible side effects on the body. The main result of using this methodology will be to support experimental studies in identifying the early stage of all the possible drug candidates and the optimal characteristics for an efficient recognition of the molecular target. Not only that, it will be possible to decrease the number of chemical compounds needed to introduce into the supply chain for the development of a new drug, consequently reducing time and costs. Finally, it will be possible to have preliminary, yet accurate, indications of the potential toxicity profile of these drugs by applying the same methodology to the proteins that should not be simultaneously recognized by the same compound and which must therefore maintain their functionality even during the start and during the development of the disease."

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Identifying a new drug is a timely and complex process, taking an average of ten years to complete, and includes substantial economic resources and various transversal scientific skills. Reducing the amount of time needed to identify a new drug, especially in a scenario such as the current Covid-19 pandemic, would be enormously beneficial. Recent developments in information technology together with advances in pharmaceutical chemistry have led to "simulating the entire recognition process between a drug and its molecular target." As such, using an accurate virtual replication, the goal is to precisely understand what happens in the human body and then translate results into therapeutic action.

The Molecular Modeling Section (MMS) of the Department of Pharmaceutical and Pharmacological Sciences at the University of Padua has developed, under a reasonable timeline and with a high level of accuracy, a methodology that follows the path of a drug as it encounters and recognizes a particular region of a molecular target in order for it to perform its function.

Led by Prof Stefano Moro and his team from the Department of Pharmaceutical and Pharmacological Sciences, the work published in "Scientific Reports" is based on the mechanism of action of a drug at the molecular level and entitled, Targeting the coronavirus SARS-CoV-2: computational insights into the mechanism of action of the protease inhibitors lopinavir, ritonavir and nelfinavir (Giovanni Bolcato, Maicol Bissaro, Matteo Pavan, Mattia Sturlese, & Stefano Moro).

To date, no molecular details are available regarding the mechanism of action of antiviral drugs that support a clinical use to fight the Covid-19 emergency. Historically, the treatment strategy is to use previous clinical evidence to prove effectiveness in other pathologies and then apply this under new contexts during a pandemic. Pre-approved pharmacological treatments for other viral infections were used against the virus during the first wave of the SARS-CoV-2 emergency, setting a base for the treatment of Covid-19. Taking advantage of evidence discovered during the first coronavirus pandemic (SARS, 2002-2003), doctors have adopted a therapeutic approach using HIV antiretroviral drugs. Doctors gathered the positive preliminary indications on the effectiveness of the treatment while waiting for an effective vaccine.

Prof. Stefano Moro explains, "The particular technique that was developed in our laboratory is called supervised molecular dynamics (SuMD). This technique has found its application, in the midst of the SARS-CoV-2 coronavirus pandemic, by describing the molecular recognition between the main protease Mpro, an important virus protein, and three drugs previously used in the clinical setting for the pathological treatment of viral infections. Of the three drugs used, the molecular description of their mechanism of action with the Mpro protease was still unknown.” This technique allows us to follow how the drug approaches its target protein over time, as well as in which region the surface recognition occurs, and what recognizable chemical property of the drug carries out its success.

PhD students Giovanni Bolcato and Maicol Bissaro from MMS of the Department of Pharmaceutical and Pharmacological Sciences explain, “In addition to interpreting, at an atomic level, the mechanism recognized between the three drugs (Lopinavir, Ritonavir and Nelfinavir) and where the Mpro protease takes place, the application of this methodology lays the foundations for a new phase of potential drug designs for the same viral protein and other proteins needed during the SARS-CoV-2 replication cycle. This computational technique allows us to suggest new chemical structures that present better therapeutic efficacy as well as reducing possible side effects on the body. The main result of using this methodology will be to support experimental studies in identifying the early stage of all the possible drug candidates and the optimal characteristics for an efficient recognition of the molecular target. Not only that, it will be possible to decrease the number of chemical compounds needed to introduce into the supply chain for the development of a new drug, consequently reducing time and costs. Finally, it will be possible to have preliminary, yet accurate, indications of the potential toxicity profile of these drugs by applying the same methodology to the proteins that should not be simultaneously recognized by the same compound and which must therefore maintain their functionality even during the start and during the development of the disease."

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Identifying a new drug is a timely and complex process, taking an average of ten years to complete, and includes substantial economic resources and various transversal scientific skills. Reducing the amount of time needed to identify a new drug, especially in a scenario such as the current Covid-19 pandemic, would be enormously beneficial. Recent developments in information technology together with advances in pharmaceutical chemistry have led to "simulating the entire recognition process between a drug and its molecular target." As such, using an accurate virtual replication, the goal is to precisely understand what happens in the human body and then translate results into therapeutic action.

The Molecular Modeling Section (MMS) of the Department of Pharmaceutical and Pharmacological Sciences at the University of Padua has developed, under a reasonable timeline and with a high level of accuracy, a methodology that follows the path of a drug as it encounters and recognizes a particular region of a molecular target in order for it to perform its function.

Led by Prof Stefano Moro and his team from the Department of Pharmaceutical and Pharmacological Sciences, the work published in "Scientific Reports" is based on the mechanism of action of a drug at the molecular level and entitled, Targeting the coronavirus SARS-CoV-2: computational insights into the mechanism of action of the protease inhibitors lopinavir, ritonavir and nelfinavir (Giovanni Bolcato, Maicol Bissaro, Matteo Pavan, Mattia Sturlese, & Stefano Moro).

To date, no molecular details are available regarding the mechanism of action of antiviral drugs that support a clinical use to fight the Covid-19 emergency. Historically, the treatment strategy is to use previous clinical evidence to prove effectiveness in other pathologies and then apply this under new contexts during a pandemic. Pre-approved pharmacological treatments for other viral infections were used against the virus during the first wave of the SARS-CoV-2 emergency, setting a base for the treatment of Covid-19. Taking advantage of evidence discovered during the first coronavirus pandemic (SARS, 2002-2003), doctors have adopted a therapeutic approach using HIV antiretroviral drugs. Doctors gathered the positive preliminary indications on the effectiveness of the treatment while waiting for an effective vaccine.

Prof. Stefano Moro explains, "The particular technique that was developed in our laboratory is called supervised molecular dynamics (SuMD). This technique has found its application, in the midst of the SARS-CoV-2 coronavirus pandemic, by describing the molecular recognition between the main protease Mpro, an important virus protein, and three drugs previously used in the clinical setting for the pathological treatment of viral infections. Of the three drugs used, the molecular description of their mechanism of action with the Mpro protease was still unknown.” This technique allows us to follow how the drug approaches its target protein over time, as well as in which region the surface recognition occurs, and what recognizable chemical property of the drug carries out its success.

PhD students Giovanni Bolcato and Maicol Bissaro from MMS of the Department of Pharmaceutical and Pharmacological Sciences explain, “In addition to interpreting, at an atomic level, the mechanism recognized between the three drugs (Lopinavir, Ritonavir and Nelfinavir) and where the Mpro protease takes place, the application of this methodology lays the foundations for a new phase of potential drug designs for the same viral protein and other proteins needed during the SARS-CoV-2 replication cycle. This computational technique allows us to suggest new chemical structures that present better therapeutic efficacy as well as reducing possible side effects on the body. The main result of using this methodology will be to support experimental studies in identifying the early stage of all the possible drug candidates and the optimal characteristics for an efficient recognition of the molecular target. Not only that, it will be possible to decrease the number of chemical compounds needed to introduce into the supply chain for the development of a new drug, consequently reducing time and costs. Finally, it will be possible to have preliminary, yet accurate, indications of the potential toxicity profile of these drugs by applying the same methodology to the proteins that should not be simultaneously recognized by the same compound and which must therefore maintain their functionality even during the start and during the development of the disease."

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Identifying a new drug is a timely and complex process, taking an average of ten years to complete, and includes substantial economic resources and various transversal scientific skills. Reducing the amount of time needed to identify a new drug, especially in a scenario such as the current Covid-19 pandemic, would be enormously beneficial. Recent developments in information technology together with advances in pharmaceutical chemistry have led to "simulating the entire recognition process between a drug and its molecular target." As such, using an accurate virtual replication, the goal is to precisely understand what happens in the human body and then translate results into therapeutic action.

The Molecular Modeling Section (MMS) of the Department of Pharmaceutical and Pharmacological Sciences at the University of Padua has developed, under a reasonable timeline and with a high level of accuracy, a methodology that follows the path of a drug as it encounters and recognizes a particular region of a molecular target in order for it to perform its function.

Led by Prof Stefano Moro and his team from the Department of Pharmaceutical and Pharmacological Sciences, the work published in "Scientific Reports" is based on the mechanism of action of a drug at the molecular level and entitled, Targeting the coronavirus SARS-CoV-2: computational insights into the mechanism of action of the protease inhibitors lopinavir, ritonavir and nelfinavir (Giovanni Bolcato, Maicol Bissaro, Matteo Pavan, Mattia Sturlese, & Stefano Moro).

To date, no molecular details are available regarding the mechanism of action of antiviral drugs that support a clinical use to fight the Covid-19 emergency. Historically, the treatment strategy is to use previous clinical evidence to prove effectiveness in other pathologies and then apply this under new contexts during a pandemic. Pre-approved pharmacological treatments for other viral infections were used against the virus during the first wave of the SARS-CoV-2 emergency, setting a base for the treatment of Covid-19. Taking advantage of evidence discovered during the first coronavirus pandemic (SARS, 2002-2003), doctors have adopted a therapeutic approach using HIV antiretroviral drugs. Doctors gathered the positive preliminary indications on the effectiveness of the treatment while waiting for an effective vaccine.

Prof. Stefano Moro explains, "The particular technique that was developed in our laboratory is called supervised molecular dynamics (SuMD). This technique has found its application, in the midst of the SARS-CoV-2 coronavirus pandemic, by describing the molecular recognition between the main protease Mpro, an important virus protein, and three drugs previously used in the clinical setting for the pathological treatment of viral infections. Of the three drugs used, the molecular description of their mechanism of action with the Mpro protease was still unknown.” This technique allows us to follow how the drug approaches its target protein over time, as well as in which region the surface recognition occurs, and what recognizable chemical property of the drug carries out its success.

PhD students Giovanni Bolcato and Maicol Bissaro from MMS of the Department of Pharmaceutical and Pharmacological Sciences explain, “In addition to interpreting, at an atomic level, the mechanism recognized between the three drugs (Lopinavir, Ritonavir and Nelfinavir) and where the Mpro protease takes place, the application of this methodology lays the foundations for a new phase of potential drug designs for the same viral protein and other proteins needed during the SARS-CoV-2 replication cycle. This computational technique allows us to suggest new chemical structures that present better therapeutic efficacy as well as reducing possible side effects on the body. The main result of using this methodology will be to support experimental studies in identifying the early stage of all the possible drug candidates and the optimal characteristics for an efficient recognition of the molecular target. Not only that, it will be possible to decrease the number of chemical compounds needed to introduce into the supply chain for the development of a new drug, consequently reducing time and costs. Finally, it will be possible to have preliminary, yet accurate, indications of the potential toxicity profile of these drugs by applying the same methodology to the proteins that should not be simultaneously recognized by the same compound and which must therefore maintain their functionality even during the start and during the development of the disease."

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Identifying a new drug is a timely and complex process, taking an average of ten years to complete, and includes substantial economic resources and various transversal scientific skills. Reducing the amount of time needed to identify a new drug, especially in a scenario such as the current Covid-19 pandemic, would be enormously beneficial. Recent developments in information technology together with advances in pharmaceutical chemistry have led to "simulating the entire recognition process between a drug and its molecular target." As such, using an accurate virtual replication, the goal is to precisely understand what happens in the human body and then translate results into therapeutic action.

The Molecular Modeling Section (MMS) of the Department of Pharmaceutical and Pharmacological Sciences at the University of Padua has developed, under a reasonable timeline and with a high level of accuracy, a methodology that follows the path of a drug as it encounters and recognizes a particular region of a molecular target in order for it to perform its function.

Led by Prof Stefano Moro and his team from the Department of Pharmaceutical and Pharmacological Sciences, the work published in "Scientific Reports" is based on the mechanism of action of a drug at the molecular level and entitled, Targeting the coronavirus SARS-CoV-2: computational insights into the mechanism of action of the protease inhibitors lopinavir, ritonavir and nelfinavir (Giovanni Bolcato, Maicol Bissaro, Matteo Pavan, Mattia Sturlese, & Stefano Moro).

To date, no molecular details are available regarding the mechanism of action of antiviral drugs that support a clinical use to fight the Covid-19 emergency. Historically, the treatment strategy is to use previous clinical evidence to prove effectiveness in other pathologies and then apply this under new contexts during a pandemic. Pre-approved pharmacological treatments for other viral infections were used against the virus during the first wave of the SARS-CoV-2 emergency, setting a base for the treatment of Covid-19. Taking advantage of evidence discovered during the first coronavirus pandemic (SARS, 2002-2003), doctors have adopted a therapeutic approach using HIV antiretroviral drugs. Doctors gathered the positive preliminary indications on the effectiveness of the treatment while waiting for an effective vaccine.

Prof. Stefano Moro explains, "The particular technique that was developed in our laboratory is called supervised molecular dynamics (SuMD). This technique has found its application, in the midst of the SARS-CoV-2 coronavirus pandemic, by describing the molecular recognition between the main protease Mpro, an important virus protein, and three drugs previously used in the clinical setting for the pathological treatment of viral infections. Of the three drugs used, the molecular description of their mechanism of action with the Mpro protease was still unknown.” This technique allows us to follow how the drug approaches its target protein over time, as well as in which region the surface recognition occurs, and what recognizable chemical property of the drug carries out its success.

PhD students Giovanni Bolcato and Maicol Bissaro from MMS of the Department of Pharmaceutical and Pharmacological Sciences explain, “In addition to interpreting, at an atomic level, the mechanism recognized between the three drugs (Lopinavir, Ritonavir and Nelfinavir) and where the Mpro protease takes place, the application of this methodology lays the foundations for a new phase of potential drug designs for the same viral protein and other proteins needed during the SARS-CoV-2 replication cycle. This computational technique allows us to suggest new chemical structures that present better therapeutic efficacy as well as reducing possible side effects on the body. The main result of using this methodology will be to support experimental studies in identifying the early stage of all the possible drug candidates and the optimal characteristics for an efficient recognition of the molecular target. Not only that, it will be possible to decrease the number of chemical compounds needed to introduce into the supply chain for the development of a new drug, consequently reducing time and costs. Finally, it will be possible to have preliminary, yet accurate, indications of the potential toxicity profile of these drugs by applying the same methodology to the proteins that should not be simultaneously recognized by the same compound and which must therefore maintain their functionality even during the start and during the development of the disease."

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Identifying a new drug is a timely and complex process, taking an average of ten years to complete, and includes substantial economic resources and various transversal scientific skills. Reducing the amount of time needed to identify a new drug, especially in a scenario such as the current Covid-19 pandemic, would be enormously beneficial. Recent developments in information technology together with advances in pharmaceutical chemistry have led to "simulating the entire recognition process between a drug and its molecular target." As such, using an accurate virtual replication, the goal is to precisely understand what happens in the human body and then translate results into therapeutic action.

The Molecular Modeling Section (MMS) of the Department of Pharmaceutical and Pharmacological Sciences at the University of Padua has developed, under a reasonable timeline and with a high level of accuracy, a methodology that follows the path of a drug as it encounters and recognizes a particular region of a molecular target in order for it to perform its function.

Led by Prof Stefano Moro and his team from the Department of Pharmaceutical and Pharmacological Sciences, the work published in "Scientific Reports" is based on the mechanism of action of a drug at the molecular level and entitled, Targeting the coronavirus SARS-CoV-2: computational insights into the mechanism of action of the protease inhibitors lopinavir, ritonavir and nelfinavir (Giovanni Bolcato, Maicol Bissaro, Matteo Pavan, Mattia Sturlese, & Stefano Moro).

To date, no molecular details are available regarding the mechanism of action of antiviral drugs that support a clinical use to fight the Covid-19 emergency. Historically, the treatment strategy is to use previous clinical evidence to prove effectiveness in other pathologies and then apply this under new contexts during a pandemic. Pre-approved pharmacological treatments for other viral infections were used against the virus during the first wave of the SARS-CoV-2 emergency, setting a base for the treatment of Covid-19. Taking advantage of evidence discovered during the first coronavirus pandemic (SARS, 2002-2003), doctors have adopted a therapeutic approach using HIV antiretroviral drugs. Doctors gathered the positive preliminary indications on the effectiveness of the treatment while waiting for an effective vaccine.

Prof. Stefano Moro explains, "The particular technique that was developed in our laboratory is called supervised molecular dynamics (SuMD). This technique has found its application, in the midst of the SARS-CoV-2 coronavirus pandemic, by describing the molecular recognition between the main protease Mpro, an important virus protein, and three drugs previously used in the clinical setting for the pathological treatment of viral infections. Of the three drugs used, the molecular description of their mechanism of action with the Mpro protease was still unknown.” This technique allows us to follow how the drug approaches its target protein over time, as well as in which region the surface recognition occurs, and what recognizable chemical property of the drug carries out its success.

PhD students Giovanni Bolcato and Maicol Bissaro from MMS of the Department of Pharmaceutical and Pharmacological Sciences explain, “In addition to interpreting, at an atomic level, the mechanism recognized between the three drugs (Lopinavir, Ritonavir and Nelfinavir) and where the Mpro protease takes place, the application of this methodology lays the foundations for a new phase of potential drug designs for the same viral protein and other proteins needed during the SARS-CoV-2 replication cycle. This computational technique allows us to suggest new chemical structures that present better therapeutic efficacy as well as reducing possible side effects on the body. The main result of using this methodology will be to support experimental studies in identifying the early stage of all the possible drug candidates and the optimal characteristics for an efficient recognition of the molecular target. Not only that, it will be possible to decrease the number of chemical compounds needed to introduce into the supply chain for the development of a new drug, consequently reducing time and costs. Finally, it will be possible to have preliminary, yet accurate, indications of the potential toxicity profile of these drugs by applying the same methodology to the proteins that should not be simultaneously recognized by the same compound and which must therefore maintain their functionality even during the start and during the development of the disease."

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2020PA245 - Allegato 1 - SSD: ING-INF/05 - SC: 09/H1

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Procedure valutative per professori di seconda fascia

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Il documento ufficiale è reperibile all’Albo on line di Ateneo

Procedura valutativa per la chiamata di un Professore di seconda fascia ai sensi dell’art. 24, comma 6, Legge 30 dicembre 2010, n. 240 – 2020PA245

Scadenza: 23 dicembre 2020 - ore 13 

Domanda telematica

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Il documento ufficiale è reperibile all’Albo on line di Ateneo

Procedura valutativa per la chiamata di un Professore di seconda fascia ai sensi dell’art. 24, comma 6, Legge 30 dicembre 2010, n. 240 – 2020PA245

Scadenza: 23 dicembre 2020 - ore 13 

Domanda telematica

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Per il rimborso spese di missione consultare la pagina dedicata

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Per il rimborso spese di missione consultare la pagina dedicata

[safe_summary] => ) ) ) [field_accordion_element] => Array ( ) [field_accordion_sottotitolo] => Array ( ) [field_accordion_titolo_fro] => Array ( [und] => Array ( [0] => Array ( [value] =>

Altre informazioni

[format] => 1 [safe_value] =>

Altre informazioni

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Ufficio Personale docente - Settore Reclutamento

Palazzo Storione
Riviera Tito Livio 6, 35123 Padova
tel. 049 827 3936/ 3170/ 3172/ 3173/ 3176/ 3162/ 3178/ 1934/ 3035/ 1937/ 1929/ 3994/ 3288
email: reclutamento.docenti@unipd.it

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Ufficio Personale docente - Settore Reclutamento

Palazzo Storione
Riviera Tito Livio 6, 35123 Padova
tel. 049 827 3936/ 3170/ 3172/ 3173/ 3176/ 3162/ 3178/ 1934/ 3035/ 1937/ 1929/ 3994/ 3288
email: reclutamento.docenti@unipd.it

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Il documento ufficiale è reperibile all’Albo on line di Ateneo

Procedura valutativa per la chiamata di un Professore di seconda fascia ai sensi dell’art. 24, comma 6, Legge 30 dicembre 2010, n. 240 – 2020PA245

Scadenza: 23 dicembre 2020 - ore 13 

Domanda telematica

[summary] => [format] => 2 [safe_value] =>

Il documento ufficiale è reperibile all’Albo on line di Ateneo

Procedura valutativa per la chiamata di un Professore di seconda fascia ai sensi dell’art. 24, comma 6, Legge 30 dicembre 2010, n. 240 – 2020PA245

Scadenza: 23 dicembre 2020 - ore 13 

Domanda telematica

[safe_summary] => ) ) [#formatter] => text_summary_or_trimmed [0] => Array ( [#markup] =>

Il documento ufficiale è reperibile all’Albo on line di Ateneo

Procedura valutativa per la chiamata di un Professore di seconda fascia ai sensi dell’art. 24, comma 6, Legge 30 dicembre 2010, n. 240 – 2020PA245

Scadenza: 23 dicembre 2020 - ore 13 

Domanda telematica

) ) [field_foglia_complessa_accordion] => Array ( [#theme] => field [#weight] => -1 [#title] => accordion [#access] => 1 [#label_display] => above [#view_mode] => teaser [#language] => und [#field_name] => field_foglia_complessa_accordion [#field_type] => node_reference [#field_translatable] => 0 [#entity_type] => node [#bundle] => foglia_complessa [#object] => stdClass Object ( [vid] => 348572 [uid] => 32 [title] => Procedure valutative per professori di seconda fascia [log] => [status] => 1 [comment] => 0 [promote] => 1 [sticky] => 0 [nid] => 73583 [type] => foglia_complessa [language] => it [created] => 1606984261 [changed] => 1615451716 [tnid] => 0 [translate] => 0 [revision_timestamp] => 1615451716 [revision_uid] => 4 [taxonomy_vocabulary_2] => Array ( ) [taxonomy_vocabulary_3] => Array ( ) [taxonomy_vocabulary_8] => Array ( ) [body] => Array ( [und] => Array ( [0] => Array ( [value] =>

Il documento ufficiale è reperibile all’Albo on line di Ateneo

Procedura valutativa per la chiamata di un Professore di seconda fascia ai sensi dell’art. 24, comma 6, Legge 30 dicembre 2010, n. 240 – 2020PA245

Scadenza: 23 dicembre 2020 - ore 13 

Domanda telematica

[summary] => [format] => 2 [safe_value] =>

Il documento ufficiale è reperibile all’Albo on line di Ateneo

Procedura valutativa per la chiamata di un Professore di seconda fascia ai sensi dell’art. 24, comma 6, Legge 30 dicembre 2010, n. 240 – 2020PA245

Scadenza: 23 dicembre 2020 - ore 13 

Domanda telematica

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Per il rimborso spese di missione consultare la pagina dedicata

[summary] => [format] => 2 [safe_value] =>

Per il rimborso spese di missione consultare la pagina dedicata

[safe_summary] => ) ) ) [field_accordion_element] => Array ( ) [field_accordion_sottotitolo] => Array ( ) [field_accordion_titolo_fro] => Array ( [und] => Array ( [0] => Array ( [value] =>

Altre informazioni

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Altre informazioni

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Ufficio Personale docente - Settore Reclutamento

Palazzo Storione
Riviera Tito Livio 6, 35123 Padova
tel. 049 827 3936/ 3170/ 3172/ 3173/ 3176/ 3162/ 3178/ 1934/ 3035/ 1937/ 1929/ 3994/ 3288
email: reclutamento.docenti@unipd.it

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Ufficio Personale docente - Settore Reclutamento

Palazzo Storione
Riviera Tito Livio 6, 35123 Padova
tel. 049 827 3936/ 3170/ 3172/ 3173/ 3176/ 3162/ 3178/ 1934/ 3035/ 1937/ 1929/ 3994/ 3288
email: reclutamento.docenti@unipd.it

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Per il rimborso spese di missione consultare la pagina dedicata

[summary] => [format] => 2 [safe_value] =>

Per il rimborso spese di missione consultare la pagina dedicata

[safe_summary] => ) ) ) [field_accordion_element] => Array ( ) [field_accordion_sottotitolo] => Array ( ) [field_accordion_titolo_fro] => Array ( [und] => Array ( [0] => Array ( [value] =>

Altre informazioni

[format] => 1 [safe_value] =>

Altre informazioni

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Per il rimborso spese di missione consultare la pagina dedicata

[summary] => [format] => 2 [safe_value] =>

Per il rimborso spese di missione consultare la pagina dedicata

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Altre informazioni

[format] => 1 [safe_value] =>

Altre informazioni

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Il documento ufficiale è reperibile all’Albo on line di Ateneo

Procedura valutativa per la chiamata di un Professore di seconda fascia ai sensi dell’art. 24, comma 6, Legge 30 dicembre 2010, n. 240 – 2020PA245

Scadenza: 23 dicembre 2020 - ore 13 

Domanda telematica

[summary] => [format] => 2 [safe_value] =>

Il documento ufficiale è reperibile all’Albo on line di Ateneo

Procedura valutativa per la chiamata di un Professore di seconda fascia ai sensi dell’art. 24, comma 6, Legge 30 dicembre 2010, n. 240 – 2020PA245

Scadenza: 23 dicembre 2020 - ore 13 

Domanda telematica

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Per il rimborso spese di missione consultare la pagina dedicata

[summary] => [format] => 2 [safe_value] =>

Per il rimborso spese di missione consultare la pagina dedicata

[safe_summary] => ) ) ) [field_accordion_element] => Array ( ) [field_accordion_sottotitolo] => Array ( ) [field_accordion_titolo_fro] => Array ( [und] => Array ( [0] => Array ( [value] =>

Altre informazioni

[format] => 1 [safe_value] =>

Altre informazioni

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Ufficio Personale docente - Settore Reclutamento

Palazzo Storione
Riviera Tito Livio 6, 35123 Padova
tel. 049 827 3936/ 3170/ 3172/ 3173/ 3176/ 3162/ 3178/ 1934/ 3035/ 1937/ 1929/ 3994/ 3288
email: reclutamento.docenti@unipd.it

[format] => 1 [safe_value] =>

Ufficio Personale docente - Settore Reclutamento

Palazzo Storione
Riviera Tito Livio 6, 35123 Padova
tel. 049 827 3936/ 3170/ 3172/ 3173/ 3176/ 3162/ 3178/ 1934/ 3035/ 1937/ 1929/ 3994/ 3288
email: reclutamento.docenti@unipd.it

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a:2:{s:13:"form_build_id";s:48:"form-WsCySmos4vAVlyFhG6gU5T7knfAyqco8LxlocSU_yIA";s:14:"wysiwyg_status";a:1:{i:1;i:1;}} [num_revisions] => 5 [current_revision_id] => 348572 [is_current] => 1 [is_pending] => [revision_moderation] => [entity_view_prepared] => 1 ) [#items] => Array ( [0] => Array ( [nid] => 8456 [access] => 1 [node] => stdClass Object ( [vid] => 443433 [uid] => 4 [title] => Ufficio Personale docente - Settore Reclutamento [log] => [status] => 1 [comment] => 0 [promote] => 1 [sticky] => 0 [nid] => 8456 [type] => testo_opzionale [language] => und [created] => 1341050862 [changed] => 1701255566 [tnid] => 0 [translate] => 0 [revision_timestamp] => 1701255566 [revision_uid] => 4 [field_testo_opz] => Array ( [und] => Array ( [0] => Array ( [value] =>

Ufficio Personale docente - Settore Reclutamento

Palazzo Storione
Riviera Tito Livio 6, 35123 Padova
tel. 049 827 3936/ 3170/ 3172/ 3173/ 3176/ 3162/ 3178/ 1934/ 3035/ 1937/ 1929/ 3994/ 3288
email: reclutamento.docenti@unipd.it

[format] => 1 [safe_value] =>

Ufficio Personale docente - Settore Reclutamento

Palazzo Storione
Riviera Tito Livio 6, 35123 Padova
tel. 049 827 3936/ 3170/ 3172/ 3173/ 3176/ 3162/ 3178/ 1934/ 3035/ 1937/ 1929/ 3994/ 3288
email: reclutamento.docenti@unipd.it

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Ufficio Personale docente - Settore Reclutamento

Palazzo Storione
Riviera Tito Livio 6, 35123 Padova
tel. 049 827 3936/ 3170/ 3172/ 3173/ 3176/ 3162/ 3178/ 1934/ 3035/ 1937/ 1929/ 3994/ 3288
email: reclutamento.docenti@unipd.it

[format] => 1 [safe_value] =>

Ufficio Personale docente - Settore Reclutamento

Palazzo Storione
Riviera Tito Livio 6, 35123 Padova
tel. 049 827 3936/ 3170/ 3172/ 3173/ 3176/ 3162/ 3178/ 1934/ 3035/ 1937/ 1929/ 3994/ 3288
email: reclutamento.docenti@unipd.it

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Allegati 2020PA245

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2020PA245 - Allegato 1 - SSD: ING-INF/05 - SC: 09/H1

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