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New advancements in the understanding of chronic lymphocytic leukaemia (CLL), one of the most common forms of blood cancer, have been made by an international research team coordinated by the University of Padua. The discovery pertains to certain circular RNAs, relatively unknown RNA molecules, which have been identified as key indicators for recognising the more aggressive forms of the disease with chromosomal alterations that increase the production of the BCL3 protein.

Thanks to advanced sequencing methodologies and sophisticated computational algorithms, the circular transcriptome, i.e., the collection of RNAs that are closed in a loop instead of the usual 'string' form, has been analysed for the first time in patients affected by a rare aggressive form of chronic lymphocytic leukaemia (about 1% of diagnosed cases). As a result, several circular RNAs have been identified as highly abundant in malignant cells, particularly the circCORO1C and circCLEC2D molecules, which are present in high quantities in the most severe cases of the disease.

The study, published in the journal "Journal of Hematology & Oncology" under the title "Circular RNA signature of aggressive CLL with t(14;19)(q32;q13). An ERIC study," involved young researchers such as Eleonora Roncaglia and Enrico Gaffo from the National Centre for Research and Development of Gene Therapy and RNA Drugs, funded by the NextGeneration EU programme (PNRR Mission 4 – Education and Research), who conducted pioneering analysis on circular RNAs in leukaemic cells.

Stefania Bortoluzzi from the Department of Surgical, Oncological and Gastroenterological Sciences at the University of Padua, co-coordinator of the study alongside Andrea Visentin, explained: "These molecules can become true markers of tumour aggressiveness. Their discovery allows us to predict the disease's progression with greater precision and, in the future, they could become new targets for the development of RNA-based drugs."

The study involved 28 research centres and hospitals in 12 countries, but scientific coordination was managed by the University of Padua, with a central role played by the laboratories of Computational Medicine, Haematology and Molecular Biology. Researchers from Padua led the collection and analysis of samples, comparing aggressive tumour cells, common forms of leukaemia, and healthy immune system cells. "Studying such a rare and aggressive form of leukaemia required international collaboration," commented Andrea Visentin, who collected samples from various countries, including Sweden, Greece, the United States, and China. "But it is thanks to the commitment and innovation of our young researchers that we have managed to make this significant breakthrough."

The research was funded by the NextGeneration EU programme and supported by various institutions, including the AIRC Foundation for Cancer Research and the "Research for Believing in Life" association. These new insights can improve the diagnosis of chronic lymphocytic leukaemia and, as they align with the goal of finding new targets for RNA therapies, they could make the treatment of the disease more effective in the future. 

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New advancements in the understanding of chronic lymphocytic leukaemia (CLL), one of the most common forms of blood cancer, have been made by an international research team coordinated by the University of Padua. The discovery pertains to certain circular RNAs, relatively unknown RNA molecules, which have been identified as key indicators for recognising the more aggressive forms of the disease with chromosomal alterations that increase the production of the BCL3 protein.

Thanks to advanced sequencing methodologies and sophisticated computational algorithms, the circular transcriptome, i.e., the collection of RNAs that are closed in a loop instead of the usual 'string' form, has been analysed for the first time in patients affected by a rare aggressive form of chronic lymphocytic leukaemia (about 1% of diagnosed cases). As a result, several circular RNAs have been identified as highly abundant in malignant cells, particularly the circCORO1C and circCLEC2D molecules, which are present in high quantities in the most severe cases of the disease.

The study, published in the journal "Journal of Hematology & Oncology" under the title "Circular RNA signature of aggressive CLL with t(14;19)(q32;q13). An ERIC study," involved young researchers such as Eleonora Roncaglia and Enrico Gaffo from the National Centre for Research and Development of Gene Therapy and RNA Drugs, funded by the NextGeneration EU programme (PNRR Mission 4 – Education and Research), who conducted pioneering analysis on circular RNAs in leukaemic cells.

Stefania Bortoluzzi from the Department of Surgical, Oncological and Gastroenterological Sciences at the University of Padua, co-coordinator of the study alongside Andrea Visentin, explained: "These molecules can become true markers of tumour aggressiveness. Their discovery allows us to predict the disease's progression with greater precision and, in the future, they could become new targets for the development of RNA-based drugs."

The study involved 28 research centres and hospitals in 12 countries, but scientific coordination was managed by the University of Padua, with a central role played by the laboratories of Computational Medicine, Haematology and Molecular Biology. Researchers from Padua led the collection and analysis of samples, comparing aggressive tumour cells, common forms of leukaemia, and healthy immune system cells. "Studying such a rare and aggressive form of leukaemia required international collaboration," commented Andrea Visentin, who collected samples from various countries, including Sweden, Greece, the United States, and China. "But it is thanks to the commitment and innovation of our young researchers that we have managed to make this significant breakthrough."

The research was funded by the NextGeneration EU programme and supported by various institutions, including the AIRC Foundation for Cancer Research and the "Research for Believing in Life" association. These new insights can improve the diagnosis of chronic lymphocytic leukaemia and, as they align with the goal of finding new targets for RNA therapies, they could make the treatment of the disease more effective in the future. 

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New advancements in the understanding of chronic lymphocytic leukaemia (CLL), one of the most common forms of blood cancer, have been made by an international research team coordinated by the University of Padua. The discovery pertains to certain circular RNAs, relatively unknown RNA molecules, which have been identified as key indicators for recognising the more aggressive forms of the disease with chromosomal alterations that increase the production of the BCL3 protein.

Thanks to advanced sequencing methodologies and sophisticated computational algorithms, the circular transcriptome, i.e., the collection of RNAs that are closed in a loop instead of the usual 'string' form, has been analysed for the first time in patients affected by a rare aggressive form of chronic lymphocytic leukaemia (about 1% of diagnosed cases). As a result, several circular RNAs have been identified as highly abundant in malignant cells, particularly the circCORO1C and circCLEC2D molecules, which are present in high quantities in the most severe cases of the disease.

The study, published in the journal "Journal of Hematology & Oncology" under the title "Circular RNA signature of aggressive CLL with t(14;19)(q32;q13). An ERIC study," involved young researchers such as Eleonora Roncaglia and Enrico Gaffo from the National Centre for Research and Development of Gene Therapy and RNA Drugs, funded by the NextGeneration EU programme (PNRR Mission 4 – Education and Research), who conducted pioneering analysis on circular RNAs in leukaemic cells.

Stefania Bortoluzzi from the Department of Surgical, Oncological and Gastroenterological Sciences at the University of Padua, co-coordinator of the study alongside Andrea Visentin, explained: "These molecules can become true markers of tumour aggressiveness. Their discovery allows us to predict the disease's progression with greater precision and, in the future, they could become new targets for the development of RNA-based drugs."

The study involved 28 research centres and hospitals in 12 countries, but scientific coordination was managed by the University of Padua, with a central role played by the laboratories of Computational Medicine, Haematology and Molecular Biology. Researchers from Padua led the collection and analysis of samples, comparing aggressive tumour cells, common forms of leukaemia, and healthy immune system cells. "Studying such a rare and aggressive form of leukaemia required international collaboration," commented Andrea Visentin, who collected samples from various countries, including Sweden, Greece, the United States, and China. "But it is thanks to the commitment and innovation of our young researchers that we have managed to make this significant breakthrough."

The research was funded by the NextGeneration EU programme and supported by various institutions, including the AIRC Foundation for Cancer Research and the "Research for Believing in Life" association. These new insights can improve the diagnosis of chronic lymphocytic leukaemia and, as they align with the goal of finding new targets for RNA therapies, they could make the treatment of the disease more effective in the future. 

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New advancements in the understanding of chronic lymphocytic leukaemia (CLL), one of the most common forms of blood cancer, have been made by an international research team coordinated by the University of Padua. The discovery pertains to certain circular RNAs, relatively unknown RNA molecules, which have been identified as key indicators for recognising the more aggressive forms of the disease with chromosomal alterations that increase the production of the BCL3 protein.

Thanks to advanced sequencing methodologies and sophisticated computational algorithms, the circular transcriptome, i.e., the collection of RNAs that are closed in a loop instead of the usual 'string' form, has been analysed for the first time in patients affected by a rare aggressive form of chronic lymphocytic leukaemia (about 1% of diagnosed cases). As a result, several circular RNAs have been identified as highly abundant in malignant cells, particularly the circCORO1C and circCLEC2D molecules, which are present in high quantities in the most severe cases of the disease.

The study, published in the journal "Journal of Hematology & Oncology" under the title "Circular RNA signature of aggressive CLL with t(14;19)(q32;q13). An ERIC study," involved young researchers such as Eleonora Roncaglia and Enrico Gaffo from the National Centre for Research and Development of Gene Therapy and RNA Drugs, funded by the NextGeneration EU programme (PNRR Mission 4 – Education and Research), who conducted pioneering analysis on circular RNAs in leukaemic cells.

Stefania Bortoluzzi from the Department of Surgical, Oncological and Gastroenterological Sciences at the University of Padua, co-coordinator of the study alongside Andrea Visentin, explained: "These molecules can become true markers of tumour aggressiveness. Their discovery allows us to predict the disease's progression with greater precision and, in the future, they could become new targets for the development of RNA-based drugs."

The study involved 28 research centres and hospitals in 12 countries, but scientific coordination was managed by the University of Padua, with a central role played by the laboratories of Computational Medicine, Haematology and Molecular Biology. Researchers from Padua led the collection and analysis of samples, comparing aggressive tumour cells, common forms of leukaemia, and healthy immune system cells. "Studying such a rare and aggressive form of leukaemia required international collaboration," commented Andrea Visentin, who collected samples from various countries, including Sweden, Greece, the United States, and China. "But it is thanks to the commitment and innovation of our young researchers that we have managed to make this significant breakthrough."

The research was funded by the NextGeneration EU programme and supported by various institutions, including the AIRC Foundation for Cancer Research and the "Research for Believing in Life" association. These new insights can improve the diagnosis of chronic lymphocytic leukaemia and, as they align with the goal of finding new targets for RNA therapies, they could make the treatment of the disease more effective in the future. 

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New advancements in the understanding of chronic lymphocytic leukaemia (CLL), one of the most common forms of blood cancer, have been made by an international research team coordinated by the University of Padua. The discovery pertains to certain circular RNAs, relatively unknown RNA molecules, which have been identified as key indicators for recognising the more aggressive forms of the disease with chromosomal alterations that increase the production of the BCL3 protein.

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New advancements in the understanding of chronic lymphocytic leukaemia (CLL), one of the most common forms of blood cancer, have been made by an international research team coordinated by the University of Padua. The discovery pertains to certain circular RNAs, relatively unknown RNA molecules, which have been identified as key indicators for recognising the more aggressive forms of the disease with chromosomal alterations that increase the production of the BCL3 protein.

Thanks to advanced sequencing methodologies and sophisticated computational algorithms, the circular transcriptome, i.e., the collection of RNAs that are closed in a loop instead of the usual 'string' form, has been analysed for the first time in patients affected by a rare aggressive form of chronic lymphocytic leukaemia (about 1% of diagnosed cases). As a result, several circular RNAs have been identified as highly abundant in malignant cells, particularly the circCORO1C and circCLEC2D molecules, which are present in high quantities in the most severe cases of the disease.

The study, published in the journal "Journal of Hematology & Oncology" under the title "Circular RNA signature of aggressive CLL with t(14;19)(q32;q13). An ERIC study," involved young researchers such as Eleonora Roncaglia and Enrico Gaffo from the National Centre for Research and Development of Gene Therapy and RNA Drugs, funded by the NextGeneration EU programme (PNRR Mission 4 – Education and Research), who conducted pioneering analysis on circular RNAs in leukaemic cells.

Stefania Bortoluzzi from the Department of Surgical, Oncological and Gastroenterological Sciences at the University of Padua, co-coordinator of the study alongside Andrea Visentin, explained: "These molecules can become true markers of tumour aggressiveness. Their discovery allows us to predict the disease's progression with greater precision and, in the future, they could become new targets for the development of RNA-based drugs."

The study involved 28 research centres and hospitals in 12 countries, but scientific coordination was managed by the University of Padua, with a central role played by the laboratories of Computational Medicine, Haematology and Molecular Biology. Researchers from Padua led the collection and analysis of samples, comparing aggressive tumour cells, common forms of leukaemia, and healthy immune system cells. "Studying such a rare and aggressive form of leukaemia required international collaboration," commented Andrea Visentin, who collected samples from various countries, including Sweden, Greece, the United States, and China. "But it is thanks to the commitment and innovation of our young researchers that we have managed to make this significant breakthrough."

The research was funded by the NextGeneration EU programme and supported by various institutions, including the AIRC Foundation for Cancer Research and the "Research for Believing in Life" association. These new insights can improve the diagnosis of chronic lymphocytic leukaemia and, as they align with the goal of finding new targets for RNA therapies, they could make the treatment of the disease more effective in the future. 

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New advancements in the understanding of chronic lymphocytic leukaemia (CLL), one of the most common forms of blood cancer, have been made by an international research team coordinated by the University of Padua. The discovery pertains to certain circular RNAs, relatively unknown RNA molecules, which have been identified as key indicators for recognising the more aggressive forms of the disease with chromosomal alterations that increase the production of the BCL3 protein.

Thanks to advanced sequencing methodologies and sophisticated computational algorithms, the circular transcriptome, i.e., the collection of RNAs that are closed in a loop instead of the usual 'string' form, has been analysed for the first time in patients affected by a rare aggressive form of chronic lymphocytic leukaemia (about 1% of diagnosed cases). As a result, several circular RNAs have been identified as highly abundant in malignant cells, particularly the circCORO1C and circCLEC2D molecules, which are present in high quantities in the most severe cases of the disease.

The study, published in the journal "Journal of Hematology & Oncology" under the title "Circular RNA signature of aggressive CLL with t(14;19)(q32;q13). An ERIC study," involved young researchers such as Eleonora Roncaglia and Enrico Gaffo from the National Centre for Research and Development of Gene Therapy and RNA Drugs, funded by the NextGeneration EU programme (PNRR Mission 4 – Education and Research), who conducted pioneering analysis on circular RNAs in leukaemic cells.

Stefania Bortoluzzi from the Department of Surgical, Oncological and Gastroenterological Sciences at the University of Padua, co-coordinator of the study alongside Andrea Visentin, explained: "These molecules can become true markers of tumour aggressiveness. Their discovery allows us to predict the disease's progression with greater precision and, in the future, they could become new targets for the development of RNA-based drugs."

The study involved 28 research centres and hospitals in 12 countries, but scientific coordination was managed by the University of Padua, with a central role played by the laboratories of Computational Medicine, Haematology and Molecular Biology. Researchers from Padua led the collection and analysis of samples, comparing aggressive tumour cells, common forms of leukaemia, and healthy immune system cells. "Studying such a rare and aggressive form of leukaemia required international collaboration," commented Andrea Visentin, who collected samples from various countries, including Sweden, Greece, the United States, and China. "But it is thanks to the commitment and innovation of our young researchers that we have managed to make this significant breakthrough."

The research was funded by the NextGeneration EU programme and supported by various institutions, including the AIRC Foundation for Cancer Research and the "Research for Believing in Life" association. These new insights can improve the diagnosis of chronic lymphocytic leukaemia and, as they align with the goal of finding new targets for RNA therapies, they could make the treatment of the disease more effective in the future. 

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New advancements in the understanding of chronic lymphocytic leukaemia (CLL), one of the most common forms of blood cancer, have been made by an international research team coordinated by the University of Padua. The discovery pertains to certain circular RNAs, relatively unknown RNA molecules, which have been identified as key indicators for recognising the more aggressive forms of the disease with chromosomal alterations that increase the production of the BCL3 protein.

Thanks to advanced sequencing methodologies and sophisticated computational algorithms, the circular transcriptome, i.e., the collection of RNAs that are closed in a loop instead of the usual 'string' form, has been analysed for the first time in patients affected by a rare aggressive form of chronic lymphocytic leukaemia (about 1% of diagnosed cases). As a result, several circular RNAs have been identified as highly abundant in malignant cells, particularly the circCORO1C and circCLEC2D molecules, which are present in high quantities in the most severe cases of the disease.

The study, published in the journal "Journal of Hematology & Oncology" under the title "Circular RNA signature of aggressive CLL with t(14;19)(q32;q13). An ERIC study," involved young researchers such as Eleonora Roncaglia and Enrico Gaffo from the National Centre for Research and Development of Gene Therapy and RNA Drugs, funded by the NextGeneration EU programme (PNRR Mission 4 – Education and Research), who conducted pioneering analysis on circular RNAs in leukaemic cells.

Stefania Bortoluzzi from the Department of Surgical, Oncological and Gastroenterological Sciences at the University of Padua, co-coordinator of the study alongside Andrea Visentin, explained: "These molecules can become true markers of tumour aggressiveness. Their discovery allows us to predict the disease's progression with greater precision and, in the future, they could become new targets for the development of RNA-based drugs."

The study involved 28 research centres and hospitals in 12 countries, but scientific coordination was managed by the University of Padua, with a central role played by the laboratories of Computational Medicine, Haematology and Molecular Biology. Researchers from Padua led the collection and analysis of samples, comparing aggressive tumour cells, common forms of leukaemia, and healthy immune system cells. "Studying such a rare and aggressive form of leukaemia required international collaboration," commented Andrea Visentin, who collected samples from various countries, including Sweden, Greece, the United States, and China. "But it is thanks to the commitment and innovation of our young researchers that we have managed to make this significant breakthrough."

The research was funded by the NextGeneration EU programme and supported by various institutions, including the AIRC Foundation for Cancer Research and the "Research for Believing in Life" association. These new insights can improve the diagnosis of chronic lymphocytic leukaemia and, as they align with the goal of finding new targets for RNA therapies, they could make the treatment of the disease more effective in the future. 

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New advancements in the understanding of chronic lymphocytic leukaemia (CLL), one of the most common forms of blood cancer, have been made by an international research team coordinated by the University of Padua. The discovery pertains to certain circular RNAs, relatively unknown RNA molecules, which have been identified as key indicators for recognising the more aggressive forms of the disease with chromosomal alterations that increase the production of the BCL3 protein.

Thanks to advanced sequencing methodologies and sophisticated computational algorithms, the circular transcriptome, i.e., the collection of RNAs that are closed in a loop instead of the usual 'string' form, has been analysed for the first time in patients affected by a rare aggressive form of chronic lymphocytic leukaemia (about 1% of diagnosed cases). As a result, several circular RNAs have been identified as highly abundant in malignant cells, particularly the circCORO1C and circCLEC2D molecules, which are present in high quantities in the most severe cases of the disease.

The study, published in the journal "Journal of Hematology & Oncology" under the title "Circular RNA signature of aggressive CLL with t(14;19)(q32;q13). An ERIC study," involved young researchers such as Eleonora Roncaglia and Enrico Gaffo from the National Centre for Research and Development of Gene Therapy and RNA Drugs, funded by the NextGeneration EU programme (PNRR Mission 4 – Education and Research), who conducted pioneering analysis on circular RNAs in leukaemic cells.

Stefania Bortoluzzi from the Department of Surgical, Oncological and Gastroenterological Sciences at the University of Padua, co-coordinator of the study alongside Andrea Visentin, explained: "These molecules can become true markers of tumour aggressiveness. Their discovery allows us to predict the disease's progression with greater precision and, in the future, they could become new targets for the development of RNA-based drugs."

The study involved 28 research centres and hospitals in 12 countries, but scientific coordination was managed by the University of Padua, with a central role played by the laboratories of Computational Medicine, Haematology and Molecular Biology. Researchers from Padua led the collection and analysis of samples, comparing aggressive tumour cells, common forms of leukaemia, and healthy immune system cells. "Studying such a rare and aggressive form of leukaemia required international collaboration," commented Andrea Visentin, who collected samples from various countries, including Sweden, Greece, the United States, and China. "But it is thanks to the commitment and innovation of our young researchers that we have managed to make this significant breakthrough."

The research was funded by the NextGeneration EU programme and supported by various institutions, including the AIRC Foundation for Cancer Research and the "Research for Believing in Life" association. These new insights can improve the diagnosis of chronic lymphocytic leukaemia and, as they align with the goal of finding new targets for RNA therapies, they could make the treatment of the disease more effective in the future. 

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New advancements in the understanding of chronic lymphocytic leukaemia (CLL), one of the most common forms of blood cancer, have been made by an international research team coordinated by the University of Padua. The discovery pertains to certain circular RNAs, relatively unknown RNA molecules, which have been identified as key indicators for recognising the more aggressive forms of the disease with chromosomal alterations that increase the production of the BCL3 protein.

Thanks to advanced sequencing methodologies and sophisticated computational algorithms, the circular transcriptome, i.e., the collection of RNAs that are closed in a loop instead of the usual 'string' form, has been analysed for the first time in patients affected by a rare aggressive form of chronic lymphocytic leukaemia (about 1% of diagnosed cases). As a result, several circular RNAs have been identified as highly abundant in malignant cells, particularly the circCORO1C and circCLEC2D molecules, which are present in high quantities in the most severe cases of the disease.

The study, published in the journal "Journal of Hematology & Oncology" under the title "Circular RNA signature of aggressive CLL with t(14;19)(q32;q13). An ERIC study," involved young researchers such as Eleonora Roncaglia and Enrico Gaffo from the National Centre for Research and Development of Gene Therapy and RNA Drugs, funded by the NextGeneration EU programme (PNRR Mission 4 – Education and Research), who conducted pioneering analysis on circular RNAs in leukaemic cells.

Stefania Bortoluzzi from the Department of Surgical, Oncological and Gastroenterological Sciences at the University of Padua, co-coordinator of the study alongside Andrea Visentin, explained: "These molecules can become true markers of tumour aggressiveness. Their discovery allows us to predict the disease's progression with greater precision and, in the future, they could become new targets for the development of RNA-based drugs."

The study involved 28 research centres and hospitals in 12 countries, but scientific coordination was managed by the University of Padua, with a central role played by the laboratories of Computational Medicine, Haematology and Molecular Biology. Researchers from Padua led the collection and analysis of samples, comparing aggressive tumour cells, common forms of leukaemia, and healthy immune system cells. "Studying such a rare and aggressive form of leukaemia required international collaboration," commented Andrea Visentin, who collected samples from various countries, including Sweden, Greece, the United States, and China. "But it is thanks to the commitment and innovation of our young researchers that we have managed to make this significant breakthrough."

The research was funded by the NextGeneration EU programme and supported by various institutions, including the AIRC Foundation for Cancer Research and the "Research for Believing in Life" association. These new insights can improve the diagnosis of chronic lymphocytic leukaemia and, as they align with the goal of finding new targets for RNA therapies, they could make the treatment of the disease more effective in the future. 

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New advancements in the understanding of chronic lymphocytic leukaemia (CLL), one of the most common forms of blood cancer, have been made by an international research team coordinated by the University of Padua. The discovery pertains to certain circular RNAs, relatively unknown RNA molecules, which have been identified as key indicators for recognising the more aggressive forms of the disease with chromosomal alterations that increase the production of the BCL3 protein.

Thanks to advanced sequencing methodologies and sophisticated computational algorithms, the circular transcriptome, i.e., the collection of RNAs that are closed in a loop instead of the usual 'string' form, has been analysed for the first time in patients affected by a rare aggressive form of chronic lymphocytic leukaemia (about 1% of diagnosed cases). As a result, several circular RNAs have been identified as highly abundant in malignant cells, particularly the circCORO1C and circCLEC2D molecules, which are present in high quantities in the most severe cases of the disease.

The study, published in the journal "Journal of Hematology & Oncology" under the title "Circular RNA signature of aggressive CLL with t(14;19)(q32;q13). An ERIC study," involved young researchers such as Eleonora Roncaglia and Enrico Gaffo from the National Centre for Research and Development of Gene Therapy and RNA Drugs, funded by the NextGeneration EU programme (PNRR Mission 4 – Education and Research), who conducted pioneering analysis on circular RNAs in leukaemic cells.

Stefania Bortoluzzi from the Department of Surgical, Oncological and Gastroenterological Sciences at the University of Padua, co-coordinator of the study alongside Andrea Visentin, explained: "These molecules can become true markers of tumour aggressiveness. Their discovery allows us to predict the disease's progression with greater precision and, in the future, they could become new targets for the development of RNA-based drugs."

The study involved 28 research centres and hospitals in 12 countries, but scientific coordination was managed by the University of Padua, with a central role played by the laboratories of Computational Medicine, Haematology and Molecular Biology. Researchers from Padua led the collection and analysis of samples, comparing aggressive tumour cells, common forms of leukaemia, and healthy immune system cells. "Studying such a rare and aggressive form of leukaemia required international collaboration," commented Andrea Visentin, who collected samples from various countries, including Sweden, Greece, the United States, and China. "But it is thanks to the commitment and innovation of our young researchers that we have managed to make this significant breakthrough."

The research was funded by the NextGeneration EU programme and supported by various institutions, including the AIRC Foundation for Cancer Research and the "Research for Believing in Life" association. These new insights can improve the diagnosis of chronic lymphocytic leukaemia and, as they align with the goal of finding new targets for RNA therapies, they could make the treatment of the disease more effective in the future. 

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