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Bronchopulmonary dysplasia (BPD), known as chronic lung disease of prematurity, is the most severe respiratory complication among premature infants. Despite the lack of prevention and effective therapies, an international study coordinated by Daniele De Luca, Professor of Neonatology at Paris-Saclay University, and Eugenio Baraldi, Professor of Paediatrics at the University of Padua, involving Spanish, French, and Italian centres, has shown that lung ultrasound can identify the risk of developing severe forms of BPD early, allowing timely interventions.
Published in "Lancet Regional Health Europe," the study involved about 250 premature infants. "Among these premature infants, those who developed severe BPD showed altered lung aeration and oxygenation parameters from the tenth day of life," explains Eugenio Baraldi. "These are parameters easily measurable at the bedside, in a non-invasive manner," notes Luca Bonadies, co-author of the research and an expert in lung ultrasound.
Today, two drugs (IGF1 and r-hu-SPD) are in advanced clinical trial stages by De Luca in Paris, Eugenio Baraldi, and Luca Bonadies at the Neonatology Unit of the Hospital-University of Padua. Their clinical use could be guided by lung ultrasound, which would allow early selection of the infants who can benefit most from these treatments.
Baraldi is also coordinating a Phase I study on extracellular vesicles, representing an even more innovative therapeutic approach for the prevention of BPD developed at the Paediatric Research Tower "City of Hope" in collaboration with Maurizio Muraca's research group. The efforts of the research are thus all directed towards the earliest and most personalised treatment possible of BPD, aiming to improve long-term prognosis.
The collaboration between the Universities of Padua and Paris, promoted by Rector Daniela Mapelli and the Rector of Paris-Saclay University, is part of an agreement signed in 2021 for the promotion of joint clinical and translational research projects and the exchange of young neonatologists.
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Published in "Lancet Regional Health Europe," the study involved about 250 premature infants. "Among these premature infants, those who developed severe BPD showed altered lung aeration and oxygenation parameters from the tenth day of life," explains Eugenio Baraldi. "These are parameters easily measurable at the bedside, in a non-invasive manner," notes Luca Bonadies, co-author of the research and an expert in lung ultrasound.
Today, two drugs (IGF1 and r-hu-SPD) are in advanced clinical trial stages by De Luca in Paris, Eugenio Baraldi, and Luca Bonadies at the Neonatology Unit of the Hospital-University of Padua. Their clinical use could be guided by lung ultrasound, which would allow early selection of the infants who can benefit most from these treatments.
Baraldi is also coordinating a Phase I study on extracellular vesicles, representing an even more innovative therapeutic approach for the prevention of BPD developed at the Paediatric Research Tower "City of Hope" in collaboration with Maurizio Muraca's research group. The efforts of the research are thus all directed towards the earliest and most personalised treatment possible of BPD, aiming to improve long-term prognosis.
The collaboration between the Universities of Padua and Paris, promoted by Rector Daniela Mapelli and the Rector of Paris-Saclay University, is part of an agreement signed in 2021 for the promotion of joint clinical and translational research projects and the exchange of young neonatologists.
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Today, two drugs (IGF1 and r-hu-SPD) are in advanced clinical trial stages by De Luca in Paris, Eugenio Baraldi, and Luca Bonadies at the Neonatology Unit of the Hospital-University of Padua. Their clinical use could be guided by lung ultrasound, which would allow early selection of the infants who can benefit most from these treatments.
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Published in "Lancet Regional Health Europe," the study involved about 250 premature infants. "Among these premature infants, those who developed severe BPD showed altered lung aeration and oxygenation parameters from the tenth day of life," explains Eugenio Baraldi. "These are parameters easily measurable at the bedside, in a non-invasive manner," notes Luca Bonadies, co-author of the research and an expert in lung ultrasound.
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The collaboration between the Universities of Padua and Paris, promoted by Rector Daniela Mapelli and the Rector of Paris-Saclay University, is part of an agreement signed in 2021 for the promotion of joint clinical and translational research projects and the exchange of young neonatologists.
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Today, two drugs (IGF1 and r-hu-SPD) are in advanced clinical trial stages by De Luca in Paris, Eugenio Baraldi, and Luca Bonadies at the Neonatology Unit of the Hospital-University of Padua. Their clinical use could be guided by lung ultrasound, which would allow early selection of the infants who can benefit most from these treatments.
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The collaboration between the Universities of Padua and Paris, promoted by Rector Daniela Mapelli and the Rector of Paris-Saclay University, is part of an agreement signed in 2021 for the promotion of joint clinical and translational research projects and the exchange of young neonatologists.
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Bronchopulmonary dysplasia (BPD), known as chronic lung disease of prematurity, is the most severe respiratory complication among premature infants. Despite the lack of prevention and effective therapies, an international study coordinated by Daniele De Luca, Professor of Neonatology at Paris-Saclay University, and Eugenio Baraldi, Professor of Paediatrics at the University of Padua, involving Spanish, French, and Italian centres, has shown that lung ultrasound can identify the risk of developing severe forms of BPD early, allowing timely interventions.
Published in "Lancet Regional Health Europe," the study involved about 250 premature infants. "Among these premature infants, those who developed severe BPD showed altered lung aeration and oxygenation parameters from the tenth day of life," explains Eugenio Baraldi. "These are parameters easily measurable at the bedside, in a non-invasive manner," notes Luca Bonadies, co-author of the research and an expert in lung ultrasound.
Today, two drugs (IGF1 and r-hu-SPD) are in advanced clinical trial stages by De Luca in Paris, Eugenio Baraldi, and Luca Bonadies at the Neonatology Unit of the Hospital-University of Padua. Their clinical use could be guided by lung ultrasound, which would allow early selection of the infants who can benefit most from these treatments.
Baraldi is also coordinating a Phase I study on extracellular vesicles, representing an even more innovative therapeutic approach for the prevention of BPD developed at the Paediatric Research Tower "City of Hope" in collaboration with Maurizio Muraca's research group. The efforts of the research are thus all directed towards the earliest and most personalised treatment possible of BPD, aiming to improve long-term prognosis.
The collaboration between the Universities of Padua and Paris, promoted by Rector Daniela Mapelli and the Rector of Paris-Saclay University, is part of an agreement signed in 2021 for the promotion of joint clinical and translational research projects and the exchange of young neonatologists.
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Bronchopulmonary dysplasia (BPD), known as chronic lung disease of prematurity, is the most severe respiratory complication among premature infants. Despite the lack of prevention and effective therapies, an international study coordinated by Daniele De Luca, Professor of Neonatology at Paris-Saclay University, and Eugenio Baraldi, Professor of Paediatrics at the University of Padua, involving Spanish, French, and Italian centres, has shown that lung ultrasound can identify the risk of developing severe forms of BPD early, allowing timely interventions.
Published in "Lancet Regional Health Europe," the study involved about 250 premature infants. "Among these premature infants, those who developed severe BPD showed altered lung aeration and oxygenation parameters from the tenth day of life," explains Eugenio Baraldi. "These are parameters easily measurable at the bedside, in a non-invasive manner," notes Luca Bonadies, co-author of the research and an expert in lung ultrasound.
Today, two drugs (IGF1 and r-hu-SPD) are in advanced clinical trial stages by De Luca in Paris, Eugenio Baraldi, and Luca Bonadies at the Neonatology Unit of the Hospital-University of Padua. Their clinical use could be guided by lung ultrasound, which would allow early selection of the infants who can benefit most from these treatments.
Baraldi is also coordinating a Phase I study on extracellular vesicles, representing an even more innovative therapeutic approach for the prevention of BPD developed at the Paediatric Research Tower "City of Hope" in collaboration with Maurizio Muraca's research group. The efforts of the research are thus all directed towards the earliest and most personalised treatment possible of BPD, aiming to improve long-term prognosis.
The collaboration between the Universities of Padua and Paris, promoted by Rector Daniela Mapelli and the Rector of Paris-Saclay University, is part of an agreement signed in 2021 for the promotion of joint clinical and translational research projects and the exchange of young neonatologists.
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