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As part of the seminars organized by the “Padua Neuroscience Center – PNC”, Federico Turkheimer will give a talk entitled “Imaging the Interaction between Systemic and Brain Immunity and its relevance in Major Depressive Disorder” on Thursday, 6 November 2025, at the Fondazione Ricerca Biomedica Avanzata VIMM (Sala Seminari, Fondazione Ricerca Biomedica Avanzata VIMM, Via Orus 2 – Padova - Building A, Ground Floor)
The relationship between peripheral and central immunity and how these ultimately may cause depressed behavior has been the focus of a number of imaging studies conducted with Positron Emission Tomography (PET). These studies aimed at testing the immune-mediated model of major depressive disorder (MDD): they have demonstrated mild inflammatory brain status but no correlation between central and peripheral immunity.
To gain a better insight into the relationship between heightened peripheral immunity and neuroinflammation, we estimated blood-to-brain and blood-to-CSF perfusion rates on data collected in two separate studies. Our results support a different model of peripheral-to-central immunity interaction whereas peripheral inflammation does not exert a direct neuroinflammatory “flare-up” but instead causes a “stiffening” of the BBB with consequent reduction of small molecule trafficking to and from the blood into the brain and CSF. This effect, on the long term, is likely to disrupt brain homeostasis and induce depressive symptoms.
At the same time, further analysis of these rich data-sets generated a surprise finding, e.g. the unexpected role of the skull marrow as a further locus of interaction between systemic and central immunity and brought together a novel transdiagnostic mechanism linking body-brain immunity, MDD, pain and migraines.
Federico Turkheimer is Professor in Neuroimaging (Analysis & Statistics) at the King’s College London and Theme Co-Lead for Neuroimaging at the NIHR Maudsley Biomedical Research Centre. He has worked in PET and neuroscience for the past 20 years, holding appointments at the National Institute of Mental Health (Bethesda. USA), the University of Cambridge, the MRC Cyclotron Unit (then Imanet Ltd.) at Hammersmith Hospital.
Federico Turkheimer’s main interest is in the application of mathematics and statistics to problems in neuroscience, particularly in imaging and genomics. The aim of his work is to develop in-vivo imaging markers of brain function. Together with his group, he uses Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MRI) to model brain physiology in health and disease. They focus on brain immunity and its’ relationship with the peripheral immune system and brain myelination and glymphatic function.
The seminar is held in English, and it is open to professors, researchers, lecturers, Ph.D. students, postdoctoral fellows and grant holders.
Attendance is free as long as seats are available.
FURTHER INFORMATION administration.pnc@unipd.it
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The relationship between peripheral and central immunity and how these ultimately may cause depressed behavior has been the focus of a number of imaging studies conducted with Positron Emission Tomography (PET). These studies aimed at testing the immune-mediated model of major depressive disorder (MDD): they have demonstrated mild inflammatory brain status but no correlation between central and peripheral immunity.
To gain a better insight into the relationship between heightened peripheral immunity and neuroinflammation, we estimated blood-to-brain and blood-to-CSF perfusion rates on data collected in two separate studies. Our results support a different model of peripheral-to-central immunity interaction whereas peripheral inflammation does not exert a direct neuroinflammatory “flare-up” but instead causes a “stiffening” of the BBB with consequent reduction of small molecule trafficking to and from the blood into the brain and CSF. This effect, on the long term, is likely to disrupt brain homeostasis and induce depressive symptoms.
At the same time, further analysis of these rich data-sets generated a surprise finding, e.g. the unexpected role of the skull marrow as a further locus of interaction between systemic and central immunity and brought together a novel transdiagnostic mechanism linking body-brain immunity, MDD, pain and migraines.
Federico Turkheimer is Professor in Neuroimaging (Analysis & Statistics) at the King’s College London and Theme Co-Lead for Neuroimaging at the NIHR Maudsley Biomedical Research Centre. He has worked in PET and neuroscience for the past 20 years, holding appointments at the National Institute of Mental Health (Bethesda. USA), the University of Cambridge, the MRC Cyclotron Unit (then Imanet Ltd.) at Hammersmith Hospital.
Federico Turkheimer’s main interest is in the application of mathematics and statistics to problems in neuroscience, particularly in imaging and genomics. The aim of his work is to develop in-vivo imaging markers of brain function. Together with his group, he uses Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MRI) to model brain physiology in health and disease. They focus on brain immunity and its’ relationship with the peripheral immune system and brain myelination and glymphatic function.
The seminar is held in English, and it is open to professors, researchers, lecturers, Ph.D. students, postdoctoral fellows and grant holders.
Attendance is free as long as seats are available.
FURTHER INFORMATION administration.pnc@unipd.it
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As part of the seminars organized by the “Padua Neuroscience Center – PNC”, Federico Turkheimer will give a talk entitled “Imaging the Interaction between Systemic and Brain Immunity and its relevance in Major Depressive Disorder” on Thursday, 6 November 2025, at the Fondazione Ricerca Biomedica Avanzata VIMM (Sala Seminari, Fondazione Ricerca Biomedica Avanzata VIMM, Via Orus 2 – Padova - Building A, Ground Floor)
The relationship between peripheral and central immunity and how these ultimately may cause depressed behavior has been the focus of a number of imaging studies conducted with Positron Emission Tomography (PET). These studies aimed at testing the immune-mediated model of major depressive disorder (MDD): they have demonstrated mild inflammatory brain status but no correlation between central and peripheral immunity.
To gain a better insight into the relationship between heightened peripheral immunity and neuroinflammation, we estimated blood-to-brain and blood-to-CSF perfusion rates on data collected in two separate studies. Our results support a different model of peripheral-to-central immunity interaction whereas peripheral inflammation does not exert a direct neuroinflammatory “flare-up” but instead causes a “stiffening” of the BBB with consequent reduction of small molecule trafficking to and from the blood into the brain and CSF. This effect, on the long term, is likely to disrupt brain homeostasis and induce depressive symptoms.
At the same time, further analysis of these rich data-sets generated a surprise finding, e.g. the unexpected role of the skull marrow as a further locus of interaction between systemic and central immunity and brought together a novel transdiagnostic mechanism linking body-brain immunity, MDD, pain and migraines.
Federico Turkheimer is Professor in Neuroimaging (Analysis & Statistics) at the King’s College London and Theme Co-Lead for Neuroimaging at the NIHR Maudsley Biomedical Research Centre. He has worked in PET and neuroscience for the past 20 years, holding appointments at the National Institute of Mental Health (Bethesda. USA), the University of Cambridge, the MRC Cyclotron Unit (then Imanet Ltd.) at Hammersmith Hospital.
Federico Turkheimer’s main interest is in the application of mathematics and statistics to problems in neuroscience, particularly in imaging and genomics. The aim of his work is to develop in-vivo imaging markers of brain function. Together with his group, he uses Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MRI) to model brain physiology in health and disease. They focus on brain immunity and its’ relationship with the peripheral immune system and brain myelination and glymphatic function.
The seminar is held in English, and it is open to professors, researchers, lecturers, Ph.D. students, postdoctoral fellows and grant holders.
Attendance is free as long as seats are available.
FURTHER INFORMATION administration.pnc@unipd.it
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The relationship between peripheral and central immunity and how these ultimately may cause depressed behavior has been the focus of a number of imaging studies conducted with Positron Emission Tomography (PET). These studies aimed at testing the immune-mediated model of major depressive disorder (MDD): they have demonstrated mild inflammatory brain status but no correlation between central and peripheral immunity.
To gain a better insight into the relationship between heightened peripheral immunity and neuroinflammation, we estimated blood-to-brain and blood-to-CSF perfusion rates on data collected in two separate studies. Our results support a different model of peripheral-to-central immunity interaction whereas peripheral inflammation does not exert a direct neuroinflammatory “flare-up” but instead causes a “stiffening” of the BBB with consequent reduction of small molecule trafficking to and from the blood into the brain and CSF. This effect, on the long term, is likely to disrupt brain homeostasis and induce depressive symptoms.
At the same time, further analysis of these rich data-sets generated a surprise finding, e.g. the unexpected role of the skull marrow as a further locus of interaction between systemic and central immunity and brought together a novel transdiagnostic mechanism linking body-brain immunity, MDD, pain and migraines.
Federico Turkheimer is Professor in Neuroimaging (Analysis & Statistics) at the King’s College London and Theme Co-Lead for Neuroimaging at the NIHR Maudsley Biomedical Research Centre. He has worked in PET and neuroscience for the past 20 years, holding appointments at the National Institute of Mental Health (Bethesda. USA), the University of Cambridge, the MRC Cyclotron Unit (then Imanet Ltd.) at Hammersmith Hospital.
Federico Turkheimer’s main interest is in the application of mathematics and statistics to problems in neuroscience, particularly in imaging and genomics. The aim of his work is to develop in-vivo imaging markers of brain function. Together with his group, he uses Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MRI) to model brain physiology in health and disease. They focus on brain immunity and its’ relationship with the peripheral immune system and brain myelination and glymphatic function.
The seminar is held in English, and it is open to professors, researchers, lecturers, Ph.D. students, postdoctoral fellows and grant holders.
Attendance is free as long as seats are available.
FURTHER INFORMATION administration.pnc@unipd.it
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As part of the seminars organized by the “Padua Neuroscience Center – PNC”, Federico Turkheimer will give a talk entitled “Imaging the Interaction between Systemic and Brain Immunity and its relevance in Major Depressive Disorder” on Thursday, 6 November 2025, at the Fondazione Ricerca Biomedica Avanzata VIMM (Sala Seminari, Fondazione Ricerca Biomedica Avanzata VIMM, Via Orus 2 – Padova - Building A, Ground Floor)
The relationship between peripheral and central immunity and how these ultimately may cause depressed behavior has been the focus of a number of imaging studies conducted with Positron Emission Tomography (PET). These studies aimed at testing the immune-mediated model of major depressive disorder (MDD): they have demonstrated mild inflammatory brain status but no correlation between central and peripheral immunity.
To gain a better insight into the relationship between heightened peripheral immunity and neuroinflammation, we estimated blood-to-brain and blood-to-CSF perfusion rates on data collected in two separate studies. Our results support a different model of peripheral-to-central immunity interaction whereas peripheral inflammation does not exert a direct neuroinflammatory “flare-up” but instead causes a “stiffening” of the BBB with consequent reduction of small molecule trafficking to and from the blood into the brain and CSF. This effect, on the long term, is likely to disrupt brain homeostasis and induce depressive symptoms.
At the same time, further analysis of these rich data-sets generated a surprise finding, e.g. the unexpected role of the skull marrow as a further locus of interaction between systemic and central immunity and brought together a novel transdiagnostic mechanism linking body-brain immunity, MDD, pain and migraines.
Federico Turkheimer is Professor in Neuroimaging (Analysis & Statistics) at the King’s College London and Theme Co-Lead for Neuroimaging at the NIHR Maudsley Biomedical Research Centre. He has worked in PET and neuroscience for the past 20 years, holding appointments at the National Institute of Mental Health (Bethesda. USA), the University of Cambridge, the MRC Cyclotron Unit (then Imanet Ltd.) at Hammersmith Hospital.
Federico Turkheimer’s main interest is in the application of mathematics and statistics to problems in neuroscience, particularly in imaging and genomics. The aim of his work is to develop in-vivo imaging markers of brain function. Together with his group, he uses Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MRI) to model brain physiology in health and disease. They focus on brain immunity and its’ relationship with the peripheral immune system and brain myelination and glymphatic function.
The seminar is held in English, and it is open to professors, researchers, lecturers, Ph.D. students, postdoctoral fellows and grant holders.
Attendance is free as long as seats are available.
FURTHER INFORMATION administration.pnc@unipd.it
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The relationship between peripheral and central immunity and how these ultimately may cause depressed behavior has been the focus of a number of imaging studies conducted with Positron Emission Tomography (PET). These studies aimed at testing the immune-mediated model of major depressive disorder (MDD): they have demonstrated mild inflammatory brain status but no correlation between central and peripheral immunity.
To gain a better insight into the relationship between heightened peripheral immunity and neuroinflammation, we estimated blood-to-brain and blood-to-CSF perfusion rates on data collected in two separate studies. Our results support a different model of peripheral-to-central immunity interaction whereas peripheral inflammation does not exert a direct neuroinflammatory “flare-up” but instead causes a “stiffening” of the BBB with consequent reduction of small molecule trafficking to and from the blood into the brain and CSF. This effect, on the long term, is likely to disrupt brain homeostasis and induce depressive symptoms.
At the same time, further analysis of these rich data-sets generated a surprise finding, e.g. the unexpected role of the skull marrow as a further locus of interaction between systemic and central immunity and brought together a novel transdiagnostic mechanism linking body-brain immunity, MDD, pain and migraines.
Federico Turkheimer is Professor in Neuroimaging (Analysis & Statistics) at the King’s College London and Theme Co-Lead for Neuroimaging at the NIHR Maudsley Biomedical Research Centre. He has worked in PET and neuroscience for the past 20 years, holding appointments at the National Institute of Mental Health (Bethesda. USA), the University of Cambridge, the MRC Cyclotron Unit (then Imanet Ltd.) at Hammersmith Hospital.
Federico Turkheimer’s main interest is in the application of mathematics and statistics to problems in neuroscience, particularly in imaging and genomics. The aim of his work is to develop in-vivo imaging markers of brain function. Together with his group, he uses Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MRI) to model brain physiology in health and disease. They focus on brain immunity and its’ relationship with the peripheral immune system and brain myelination and glymphatic function.
The seminar is held in English, and it is open to professors, researchers, lecturers, Ph.D. students, postdoctoral fellows and grant holders.
Attendance is free as long as seats are available.
FURTHER INFORMATION administration.pnc@unipd.it
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As part of the seminars organized by the “Padua Neuroscience Center – PNC”, Federico Turkheimer will give a talk entitled “Imaging the Interaction between Systemic and Brain Immunity and its relevance in Major Depressive Disorder” on Thursday, 6 November 2025, at the Fondazione Ricerca Biomedica Avanzata VIMM (Sala Seminari, Fondazione Ricerca Biomedica Avanzata VIMM, Via Orus 2 – Padova - Building A, Ground Floor)
The relationship between peripheral and central immunity and how these ultimately may cause depressed behavior has been the focus of a number of imaging studies conducted with Positron Emission Tomography (PET). These studies aimed at testing the immune-mediated model of major depressive disorder (MDD): they have demonstrated mild inflammatory brain status but no correlation between central and peripheral immunity.
To gain a better insight into the relationship between heightened peripheral immunity and neuroinflammation, we estimated blood-to-brain and blood-to-CSF perfusion rates on data collected in two separate studies. Our results support a different model of peripheral-to-central immunity interaction whereas peripheral inflammation does not exert a direct neuroinflammatory “flare-up” but instead causes a “stiffening” of the BBB with consequent reduction of small molecule trafficking to and from the blood into the brain and CSF. This effect, on the long term, is likely to disrupt brain homeostasis and induce depressive symptoms.
At the same time, further analysis of these rich data-sets generated a surprise finding, e.g. the unexpected role of the skull marrow as a further locus of interaction between systemic and central immunity and brought together a novel transdiagnostic mechanism linking body-brain immunity, MDD, pain and migraines.
Federico Turkheimer is Professor in Neuroimaging (Analysis & Statistics) at the King’s College London and Theme Co-Lead for Neuroimaging at the NIHR Maudsley Biomedical Research Centre. He has worked in PET and neuroscience for the past 20 years, holding appointments at the National Institute of Mental Health (Bethesda. USA), the University of Cambridge, the MRC Cyclotron Unit (then Imanet Ltd.) at Hammersmith Hospital.
Federico Turkheimer’s main interest is in the application of mathematics and statistics to problems in neuroscience, particularly in imaging and genomics. The aim of his work is to develop in-vivo imaging markers of brain function. Together with his group, he uses Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MRI) to model brain physiology in health and disease. They focus on brain immunity and its’ relationship with the peripheral immune system and brain myelination and glymphatic function.
The seminar is held in English, and it is open to professors, researchers, lecturers, Ph.D. students, postdoctoral fellows and grant holders.
Attendance is free as long as seats are available.
FURTHER INFORMATION administration.pnc@unipd.it
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The relationship between peripheral and central immunity and how these ultimately may cause depressed behavior has been the focus of a number of imaging studies conducted with Positron Emission Tomography (PET). These studies aimed at testing the immune-mediated model of major depressive disorder (MDD): they have demonstrated mild inflammatory brain status but no correlation between central and peripheral immunity.
To gain a better insight into the relationship between heightened peripheral immunity and neuroinflammation, we estimated blood-to-brain and blood-to-CSF perfusion rates on data collected in two separate studies. Our results support a different model of peripheral-to-central immunity interaction whereas peripheral inflammation does not exert a direct neuroinflammatory “flare-up” but instead causes a “stiffening” of the BBB with consequent reduction of small molecule trafficking to and from the blood into the brain and CSF. This effect, on the long term, is likely to disrupt brain homeostasis and induce depressive symptoms.
At the same time, further analysis of these rich data-sets generated a surprise finding, e.g. the unexpected role of the skull marrow as a further locus of interaction between systemic and central immunity and brought together a novel transdiagnostic mechanism linking body-brain immunity, MDD, pain and migraines.
Federico Turkheimer is Professor in Neuroimaging (Analysis & Statistics) at the King’s College London and Theme Co-Lead for Neuroimaging at the NIHR Maudsley Biomedical Research Centre. He has worked in PET and neuroscience for the past 20 years, holding appointments at the National Institute of Mental Health (Bethesda. USA), the University of Cambridge, the MRC Cyclotron Unit (then Imanet Ltd.) at Hammersmith Hospital.
Federico Turkheimer’s main interest is in the application of mathematics and statistics to problems in neuroscience, particularly in imaging and genomics. The aim of his work is to develop in-vivo imaging markers of brain function. Together with his group, he uses Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MRI) to model brain physiology in health and disease. They focus on brain immunity and its’ relationship with the peripheral immune system and brain myelination and glymphatic function.
The seminar is held in English, and it is open to professors, researchers, lecturers, Ph.D. students, postdoctoral fellows and grant holders.
Attendance is free as long as seats are available.
FURTHER INFORMATION administration.pnc@unipd.it
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As part of the seminars organized by the “Padua Neuroscience Center – PNC”, Federico Turkheimer will give a talk entitled “Imaging the Interaction between Systemic and Brain Immunity and its relevance in Major Depressive Disorder” on Thursday, 6 November 2025, at the Fondazione Ricerca Biomedica Avanzata VIMM (Sala Seminari, Fondazione Ricerca Biomedica Avanzata VIMM, Via Orus 2 – Padova - Building A, Ground Floor)
The relationship between peripheral and central immunity and how these ultimately may cause depressed behavior has been the focus of a number of imaging studies conducted with Positron Emission Tomography (PET). These studies aimed at testing the immune-mediated model of major depressive disorder (MDD): they have demonstrated mild inflammatory brain status but no correlation between central and peripheral immunity.
To gain a better insight into the relationship between heightened peripheral immunity and neuroinflammation, we estimated blood-to-brain and blood-to-CSF perfusion rates on data collected in two separate studies. Our results support a different model of peripheral-to-central immunity interaction whereas peripheral inflammation does not exert a direct neuroinflammatory “flare-up” but instead causes a “stiffening” of the BBB with consequent reduction of small molecule trafficking to and from the blood into the brain and CSF. This effect, on the long term, is likely to disrupt brain homeostasis and induce depressive symptoms.
At the same time, further analysis of these rich data-sets generated a surprise finding, e.g. the unexpected role of the skull marrow as a further locus of interaction between systemic and central immunity and brought together a novel transdiagnostic mechanism linking body-brain immunity, MDD, pain and migraines.
Federico Turkheimer is Professor in Neuroimaging (Analysis & Statistics) at the King’s College London and Theme Co-Lead for Neuroimaging at the NIHR Maudsley Biomedical Research Centre. He has worked in PET and neuroscience for the past 20 years, holding appointments at the National Institute of Mental Health (Bethesda. USA), the University of Cambridge, the MRC Cyclotron Unit (then Imanet Ltd.) at Hammersmith Hospital.
Federico Turkheimer’s main interest is in the application of mathematics and statistics to problems in neuroscience, particularly in imaging and genomics. The aim of his work is to develop in-vivo imaging markers of brain function. Together with his group, he uses Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MRI) to model brain physiology in health and disease. They focus on brain immunity and its’ relationship with the peripheral immune system and brain myelination and glymphatic function.
The seminar is held in English, and it is open to professors, researchers, lecturers, Ph.D. students, postdoctoral fellows and grant holders.
Attendance is free as long as seats are available.
FURTHER INFORMATION administration.pnc@unipd.it
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The relationship between peripheral and central immunity and how these ultimately may cause depressed behavior has been the focus of a number of imaging studies conducted with Positron Emission Tomography (PET). These studies aimed at testing the immune-mediated model of major depressive disorder (MDD): they have demonstrated mild inflammatory brain status but no correlation between central and peripheral immunity.
To gain a better insight into the relationship between heightened peripheral immunity and neuroinflammation, we estimated blood-to-brain and blood-to-CSF perfusion rates on data collected in two separate studies. Our results support a different model of peripheral-to-central immunity interaction whereas peripheral inflammation does not exert a direct neuroinflammatory “flare-up” but instead causes a “stiffening” of the BBB with consequent reduction of small molecule trafficking to and from the blood into the brain and CSF. This effect, on the long term, is likely to disrupt brain homeostasis and induce depressive symptoms.
At the same time, further analysis of these rich data-sets generated a surprise finding, e.g. the unexpected role of the skull marrow as a further locus of interaction between systemic and central immunity and brought together a novel transdiagnostic mechanism linking body-brain immunity, MDD, pain and migraines.
Federico Turkheimer is Professor in Neuroimaging (Analysis & Statistics) at the King’s College London and Theme Co-Lead for Neuroimaging at the NIHR Maudsley Biomedical Research Centre. He has worked in PET and neuroscience for the past 20 years, holding appointments at the National Institute of Mental Health (Bethesda. USA), the University of Cambridge, the MRC Cyclotron Unit (then Imanet Ltd.) at Hammersmith Hospital.
Federico Turkheimer’s main interest is in the application of mathematics and statistics to problems in neuroscience, particularly in imaging and genomics. The aim of his work is to develop in-vivo imaging markers of brain function. Together with his group, he uses Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MRI) to model brain physiology in health and disease. They focus on brain immunity and its’ relationship with the peripheral immune system and brain myelination and glymphatic function.
The seminar is held in English, and it is open to professors, researchers, lecturers, Ph.D. students, postdoctoral fellows and grant holders.
Attendance is free as long as seats are available.
FURTHER INFORMATION administration.pnc@unipd.it
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As part of the seminars organized by the “Padua Neuroscience Center – PNC”, Federico Turkheimer will give a talk entitled “Imaging the Interaction between Systemic and Brain Immunity and its relevance in Major Depressive Disorder” on Thursday, 6 November 2025, at the Fondazione Ricerca Biomedica Avanzata VIMM (Sala Seminari, Fondazione Ricerca Biomedica Avanzata VIMM, Via Orus 2 – Padova - Building A, Ground Floor)
The relationship between peripheral and central immunity and how these ultimately may cause depressed behavior has been the focus of a number of imaging studies conducted with Positron Emission Tomography (PET). These studies aimed at testing the immune-mediated model of major depressive disorder (MDD): they have demonstrated mild inflammatory brain status but no correlation between central and peripheral immunity.
To gain a better insight into the relationship between heightened peripheral immunity and neuroinflammation, we estimated blood-to-brain and blood-to-CSF perfusion rates on data collected in two separate studies. Our results support a different model of peripheral-to-central immunity interaction whereas peripheral inflammation does not exert a direct neuroinflammatory “flare-up” but instead causes a “stiffening” of the BBB with consequent reduction of small molecule trafficking to and from the blood into the brain and CSF. This effect, on the long term, is likely to disrupt brain homeostasis and induce depressive symptoms.
At the same time, further analysis of these rich data-sets generated a surprise finding, e.g. the unexpected role of the skull marrow as a further locus of interaction between systemic and central immunity and brought together a novel transdiagnostic mechanism linking body-brain immunity, MDD, pain and migraines.
Federico Turkheimer is Professor in Neuroimaging (Analysis & Statistics) at the King’s College London and Theme Co-Lead for Neuroimaging at the NIHR Maudsley Biomedical Research Centre. He has worked in PET and neuroscience for the past 20 years, holding appointments at the National Institute of Mental Health (Bethesda. USA), the University of Cambridge, the MRC Cyclotron Unit (then Imanet Ltd.) at Hammersmith Hospital.
Federico Turkheimer’s main interest is in the application of mathematics and statistics to problems in neuroscience, particularly in imaging and genomics. The aim of his work is to develop in-vivo imaging markers of brain function. Together with his group, he uses Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MRI) to model brain physiology in health and disease. They focus on brain immunity and its’ relationship with the peripheral immune system and brain myelination and glymphatic function.
The seminar is held in English, and it is open to professors, researchers, lecturers, Ph.D. students, postdoctoral fellows and grant holders.
Attendance is free as long as seats are available.
FURTHER INFORMATION administration.pnc@unipd.it
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The relationship between peripheral and central immunity and how these ultimately may cause depressed behavior has been the focus of a number of imaging studies conducted with Positron Emission Tomography (PET). These studies aimed at testing the immune-mediated model of major depressive disorder (MDD): they have demonstrated mild inflammatory brain status but no correlation between central and peripheral immunity.
To gain a better insight into the relationship between heightened peripheral immunity and neuroinflammation, we estimated blood-to-brain and blood-to-CSF perfusion rates on data collected in two separate studies. Our results support a different model of peripheral-to-central immunity interaction whereas peripheral inflammation does not exert a direct neuroinflammatory “flare-up” but instead causes a “stiffening” of the BBB with consequent reduction of small molecule trafficking to and from the blood into the brain and CSF. This effect, on the long term, is likely to disrupt brain homeostasis and induce depressive symptoms.
At the same time, further analysis of these rich data-sets generated a surprise finding, e.g. the unexpected role of the skull marrow as a further locus of interaction between systemic and central immunity and brought together a novel transdiagnostic mechanism linking body-brain immunity, MDD, pain and migraines.
Federico Turkheimer is Professor in Neuroimaging (Analysis & Statistics) at the King’s College London and Theme Co-Lead for Neuroimaging at the NIHR Maudsley Biomedical Research Centre. He has worked in PET and neuroscience for the past 20 years, holding appointments at the National Institute of Mental Health (Bethesda. USA), the University of Cambridge, the MRC Cyclotron Unit (then Imanet Ltd.) at Hammersmith Hospital.
Federico Turkheimer’s main interest is in the application of mathematics and statistics to problems in neuroscience, particularly in imaging and genomics. The aim of his work is to develop in-vivo imaging markers of brain function. Together with his group, he uses Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MRI) to model brain physiology in health and disease. They focus on brain immunity and its’ relationship with the peripheral immune system and brain myelination and glymphatic function.
The seminar is held in English, and it is open to professors, researchers, lecturers, Ph.D. students, postdoctoral fellows and grant holders.
Attendance is free as long as seats are available.
FURTHER INFORMATION administration.pnc@unipd.it
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