YR - MSCA Researcher: Mara Doimo


PDFProject:  EpiG4Mito - The mitochondrial epigenome: the role of DNA secondary structures and base modifications in the pathophysiology of mtDNA replication


Mara Doimo

 

YR - MSCA Researcher: Mara Doimo

Department:  Department of Women’s and Children’s Health

Total Contribution:  Euro 299.600,00

Project Duration in months: 36

 

 

Mara Doimo obtained her B.Sc. and M.Sc. in Medical Biotechnology at the University of Padua. During her master, she was a visiting student at the University of Geneva (Switzerland) in the laboratory of Prof. Luca Scorrano. She earned her PhD in Medical Development at the University of Padua, working on inborn errors of metabolism, with particular focus on mitochondrial disorders.

In 2016, Mara was awarded an HORIZON 2020-Marie-Sklodowska-Curie Individual Fellowship (Project ID 751474) and the Wenner Gren Foundation post-doctoral Fellowship to move to Umea University (Sweden) in the lab of Prof. Sjoerd Wanrooij. There, she studied the processes of DNA replication and repair. Her research focused on the role of non-canonical secondary structures, called G-quadruplexes (G4), in genome instability and on the pathogenesis of mitochondrial DNA maintenance disorders (MDMD).

In 2022, she moved back to the University of Padua where she has been granted the PNRR Young Researchers-MSCA. With the EpiG4Mito project, Mara aims to shed light on the effects of non-canonical secondary structures and epigenetic modifications on mitochondrial DNA stability and to clarify the mechanism leading to loss of mitochondrial DNA integrity.