MSCA PF Fellow: Giada Rossignoli

PDFProject:  PLURImet - Building a metabolic atlas of human pluripotency: dissecting the interplay between pluripotency and metabolism in human stem cells

Giada Rossignoli


MSCA Fellow: Giada Rossignoli

UNIPD Supervisor: Graziano Martello

Department: Biology

Total Contribution:  Euro 172.750,08

Project Duration in months: 24

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Giada Rossignoli obtained an MSc in Bioinformatics and Medical Biotechnology and a Ph.D. in Biomolecular Medicine at the University of Verona (Italy). During this period, she focused on neuronal biochemistry and molecular studies comparing wild-type and neurometabolic diseases-associated enzymatic variants. She later moved to University College London (UCL, UK) to develop iPSCs-derived neuronal models of neurometabolic disorders, affecting in particular the dopaminergic system, and employ them to unravel the molecular bases of different diseases and to test new therapeutic strategies. During her studies, she got fascinated by metabolism and its changes. 

Her project as an MSCA fellow is undertaken under the supervision of Prof Graziano Martello at the Department of Biology. She will assess the interplay between pluripotency and metabolism in induction, maintenance, and exit from the human naïve pluripotent state. She will do so by combining different in vitro stem cell states and interconversion processes, with multi-omics analyses integrated with computational modelling. The overall aim is to produce a comprehensive metabolic model of naïve human pluripotent stem cells and clarify the role of metabolism in the control of human naïve pluripotency.