MSCA IF Fellow: Jonathan Lambert

PDFProject:  MitoFORMSinHF - Mitochondrial cristae form, function, and organization dependent upon metabolic sources and implication in heart failure

Jonathan Lambert


MSCA Fellow: Jonathan Lambert

UNIPD Supervisor: Luca Scorrano

Department: Biology

Total Contribution: Euro 171.473,28

Project Duration in months: 24

Start Date: 01/09/2022
End Date: 31/08/2024


Jonathan Lambert is an American basic cardiovascular biologist with particular research interests in mitochondrial biology and cell death. He received his Ph.D. in Biomedical Sciences from Temple University in Philadelphia, Pennsylvania conducting research under his mentor, Dr. John Elrod, whose lab primarily focused on investigating mitochondrial calcium exchange in cardiovascular biology. Jonathan's thesis project defined MCUBs precise role in regulating the mitochondrial calcium uniporter complex and discovered MCUBs relevance to cardiac pathophysiology finding MCUB was upregulated following myocardial ischemia reperfusion injury as a compensatory mechanism to limit mitochondrial calcium overload and necrotic cell death. In 2019, Jonathan was awarded a European Molecular Biology Organization postdoctoral fellowship which is currently being carried out under the supervision of Prof. Luca Scorrano in the Department of Biology at the University of Padua. In this project entitled "Determining the metabolic sensing capability of mitochondrial cristae" Jonathan is employing discovery-based proteomics to find metabolically dependent regulators of cristae morphology and will further evaluate these candidates influence on cristae using super resolution microscopy. In 2020, Jonathan was awarded a MSCA-2020 Individual Fellowship for his project MitoFORMSinHF. The findings and molecular biological tools developed in Jonathan's EMBO fellowship will now be extended to the field of cardiovascular biology allowing him to investigate how mitochondrial cristae form, organization, and structure are dependent upon metabolic sources in the setting of heart failure. This project will also be supervised under the guidance of Prof. Luca Scorrano in the Department of Biology.