Address book
Contacts
GUGLIELMINA FROLDI
Position
Professoressa Associata
Address
VIA F. MARZOLO, 5 - PADOVA
Telephone
0498275092
1984: Degree summa cum laude in Pharmacy, University of Padova.
1986-1990: Doctorate in Pharmacology and Toxicology, Department of Pharmacology, University of Padova, Supervisor: Prof. Giuliana Fassina.
1989: Exchange PhD student, Cardiovascular laboratory, Department of Pharmacology-Division-JHMHC Cardiology, University of Florida (USA), Supervisor: Prof. Luiz Belardinelli
1991-1992: Post-Doc, Department of Pharmacology, University of Padova, and Supervisor: Prof. Giuliana Fassina.
1992: Assistant Professor of Pharmacology (SSD BIO/14), Department of Pharmacology, University of Padova.
2006-present: Associate Professor of Pharmacology (SSD BIO/14), Department of Pharmaceutical and Pharmacological Sciences, University of Padova.
Since 1987 she is teaching courses of Pharmacology and Pharmacotherapy, Pharmacognosy, Information and Documentation of Drugs in “Pharmacy”, “Pharmaceutical Chemistry”, “Scientific Information of Drugs" and "Pharmaceutical Sciences Applied” Degree Courses.
Since 2002 she is member of the college Ph.D. degree, first in the "International Research Doctorate in Molecular and Cellular Pharmacology" of Institute of Experimental and Clinical Pharmacology and Toxicology (University of Freiburg), Department of Biochemical Pharmacology (University of Innsbruck) and Department of Pharmacology and Anaesthesiology (University of Padova), then for PhD course in "Pharmacology and Toxicology, and Intensive Therapy", lastly in the PhD Program in “Pharmacological Sciences”.
The scientific activity is documented by more than 90 manuscripts published in international journals for the most part, 70 proceedings and more than 130 contributions to national and international conferences. The academic publication activity also includes 12 chapters on topics in Pharmacognosy, Pharmacology and Toxicology.
Notices
Office hours
Tuesday from 9:00 to 15:00
at Edificio E. Meneghetti 2, I° piano. Per maggiori informazioni chiedere in portineria.
Il docente può non essere presente in studio in coincidenza con impegni di didattica frontale o in relazione ad altra attività accademica.Thursday from 9:00 to 15:00
at Edificio E. Meneghetti 2, I° piano. Per maggiori informazioni chiedere in portineria.
Il docente può non essere presente in studio in coincidenza con impegni di didattica frontale o in relazione ad altra attività accademica.
Publications
See:
https://www.ncbi.nlm.nih.gov/pubmed?term=Froldi+G%5Bauthor%5D&cmd=detailssearch
Research Area
The research activity is focused on the study of natural and synthetic compounds with pharmacological activity, primarily at the cardiovascular level, also in relation to aging. The research lines are detailed below.
1) Evaluation of antiglycating and antidiabetic activity.
This line of research focuses on the identification and characterization of compounds with potential activity in counteracting protein glycation and in the control of diabetes mellitus.
2) Study of pharmacological agents in the field of metabolic diseases.
This line of research explores the therapeutic potential of new compounds in the treatment of metabolic disorders, with particular attention to:
- Type 2 diabetes mellitus
- Obesity
- Metabolic syndrome
- Dyslipidemia
3) Investigation of molecular mechanisms involved in cardiovascular aging.
This line of research focuses on the study of cellular and molecular processes that contribute to the aging of the cardiovascular system, including:
- Oxidative stress and inflammation
- Endothelial dysfunction
- Arterial stiffness
- Age-related metabolic alterations
To these ends, various in vitro assays are employed, including:
- ORAC assay: to evaluate the antioxidant capacity of compounds
- Alpha-glucosidase activity: to study the inhibition of this key enzyme in carbohydrate metabolism
- BSA assay: to analyze the interaction of compounds with bovine serum albumin, a model for the study of protein glycation
- MTT: to assess cytotoxicity and cell viability
- HPLC-DAD analysis: for the identification and quantification of bioactive compounds
These lines of research aim to provide new knowledge and potential therapeutic approaches in the field of cardiovascular and metabolic diseases related to aging, with the objective of improving the quality of life and health of the population
Thesis proposals
Thesis Proposals
- Research theses are proposed concerning the study of natural and synthetic compounds with inhibitory activity on glycation and inflammation in the cardiovascular system. Experimental studies are conducted using various in vitro experimental models.
- Literature review theses are also offered, focusing on new pharmacological classes with particular attention to bibliographic research concerning the efficacy, pharmacokinetics, and side effects of drugs.
