Address book
Contacts
MARIA EUGENIA SORIANO GARCIA - CUERVA
Position
Professoressa Associata
Structure
Address
VIALE GIUSEPPE COLOMBO, 3 - VIA UGO BASSI, 58/B - PADOVA
Telephone
0498276236

Notices
Office hours
MEETINGS ARE AVAILABLE AFTER REQUEST BY E-MAIL
Teachings
- MOLECULAR BIOLOGY (MOD. B), AA 2024 (SCP4068096)
- MOLECULAR BIOLOGY AND GENETIC ENGINEERING INTEGRATED COURSE, AA 2024 (SCQ0093918)
- MOLECULAR BIOLOGY (MOD. B), AA 2023 (SCP4068096)
- MOLECULAR BIOLOGY AND GENETIC ENGINEERING INTEGRATED COURSE, AA 2023 (SCQ0093918)
- MOLECULAR BIOLOGY (MOD. B), AA 2022 (SCP4068096)
- MOLECULAR BIOLOGY AND GENETICS (I.C.), AA 2022 (SCP4068094)
- MOLECULAR BIOLOGY AND GENETIC ENGINEERING INTEGRATED COURSE, AA 2022 (SCQ0093918)
- MOLECULAR BIOLOGY (MOD. B), AA 2021 (SCP4068096)
- MOLECULAR BIOLOGY AND GENETICS (I.C.), AA 2021 (SCP4068094)
- MOLECULAR BIOLOGY (MOD. B), AA 2020 (SCP4068096)
- MOLECULAR BIOLOGY AND GENETICS (I.C.), AA 2020 (SCP4068094)
- MOLECULAR BIOLOGY (MOD. B), AA 2019 (SCP4068096)
- MOLECULAR BIOLOGY (MOD. B), AA 2018 (SCP4068096)
- MOLECULAR BIOLOGY (MOD. B), AA 2017 (SCP4068096)
Publications
-Carinci M, Testa B, Bordi M, Milletti G, Bonora M, Antonucci L, Ferraina C,Carro M, Kumar M, Ceglie D, Eck F, Nardacci R, le Guerroué F, Petrini S, Soriano ME, Caruana I, Doria V, Manifava M, Peron C, Lambrughi M, Tiranti V, Behrends C, Papaleo E, Pinton P, Giorgi C, Ktistaki NT, Locatelli F, Nazio F, Cecconi F. TFG binds LC3C to regulate ULK1 localization and autophagosome formation. EMBO
J. 2021 May 17;40(10):e103563. doi: 10.15252/embj.2019103563
-Betto RM, Diamante L, Perrera V, Audano M, Rapelli S, Lauria A, Incarnato D, Arboit M, Pedretti S, Rigoni G, Guerineau V, Touboul D, Stirparo GG, Lohoff T, Boroviak T, Grumati P, Soriano ME, Nichols J, Mitro N, Oliviero S, Martello G. Metabolic control of DNA methylation in naive pluripotent cells. Nat Genet. 2021Feb;53(2):215-229. doi: 10.1038/s41588-020-00770-
-Cseh AM, Fabian Z, Quintana-Cabrera R, Szabo A, Eros K, Soriano ME, Gallyas F, Scorrano L, Sumegi B. PARP Inhibitor PJ34 Protects Mitochondria and Induces DNA-Damage Mediated Apoptosis in Combination With Cisplatin or Temozolomide in B16F10 Melanoma Cells. Front Physiol. 2019 May 7;10:538. doi: 10.3389/fphys.2019.00538.
-Doni D, Rigoni G, Palumbo E, Baschiera E, Peruzzo R, De Rosa E, Caicci F, Passerini L, Bettio D, Russo A, Szabò I, Soriano ME, Salviati L, Costantini P. The displacement of frataxin from the mitochondrial cristae correlates with abnormal respiratory supercomplexes formation and bioenergetic defects in cells of Friedreich ataxia patients. FASEB J. 2021 Mar;35(3):e21362. doi:10.1096/fj.202000524RR
-Simula L, Corrado M, Accordi B, Di Rita A, Nazio F, Antonucci Y, Di Daniele A, Caicci F, Caruana I, Soriano ME, Pigazzi M, Locatelli F, Cecconi F, Campello S. JNK1 and ERK1/2 modulate lymphocyte homeostasis via BIM and DRP1 upon AICD induction. Cell Death Differ. 2020 Oct;27(10):2749-2767. doi: 10.1038/s41418-020-0540-1
-Herkenne S, Ek O, Zamberlan M, Pellattiero A, Chergova M, Chivite I, Novotná E, Rigoni G, Fonseca TB, Samardzic D, Agnellini A, Bean C, Di Benedetto G, Tiso N, Argenton F, Viola A, Soriano ME, Giacomello M, Ziviani E, Sales G, Claret M, Graupera M, Scorrano L. Developmental and Tumor Angiogenesis Requires the Mitochondria-Shaping Protein Opa1. Cell Metab. 2020 May 5;31(5):987-1003.e8.doi: 10.1016/j.cmet.2020.04.007
-Quintana-Cabrera R, Soriano ME. ER Stress Priming of Mitochondrial Respiratory suPERKomplex Assembly. Trends Endocrinol Metab. 2019 Oct;30(10):685-687. doi: 10.1016/j.tem.2019.08.003.
-Quintana-Cabrera R, Quirin C, Glytsou C, Corrado M, Urbani A, Pellattiero A, Calvo E, Vázquez J, Enríquez JA, Gerle C, Soriano ME, Bernardi P, Scorrano L. The cristae modulator Optic atrophy 1 requires mitochondrial ATP synthase oligomers to safeguard mitochondrial function. Nat Commun. 2018 Aug 24;9(1):3399. doi: 10.1038/s41467-018-05655-x.
-Amini P, Stojkov D, Felser A, Jackson CB, Courage C, Schaller A, Gelman L, Soriano ME, Nuoffer JM, Scorrano L, Benarafa C, Yousefi S, Simon HU. Neutrophil extracellular trap formation requires OPA1-dependent glycolytic ATP production. Nat Commun. 2018 Jul 27;9(1):2958. doi: 10.1038/s41467-018-05387-y
-Cogliati S, Lorenzi I, Rigoni G, Caicci F, Soriano ME. Regulation of Mitochondrial Electron Transport Chain Assembly. J Mol Biol. 2018 Dec 7;430(24):4849-4873. doi: 10.1016/j.jmb.2018.09.016
Research Area
Mitochondrial diseases are a heterogeneous group of disorders characterized by dysfunctional OXPHOS activity. A growing number of mutations in mitochondrial proteins codified by nuclear or mitochondrial DNA (mtDNA) has been associated with mitochondrial disorders. However, the number is still increasing. A crucial aspect to ensure a correct mitochondrial function is the maintenance of mtDNA, ensuring its segregation, replication, and functioning. One of the main research interests of our lab is to understand the molecular mechanisms regulating mtDNA dynamics, and how alteration in this process might affect the onset or progression of mitochondrial diseases.
A parallel research line currently ongoing is focused on the study of the mitochondrial ATAD3 protein family. This family exists as a single gene up to primates, in which it suffered a double in tandem gene duplication giving rise to ATAD3B and the putative pseudogene ATAD3C. ATAD3B is expressed only during embryogenesis in pluripotent cells, and in some tumors, suggesting a correlation between the expression of the protein and the presence of a glycolytic metabolism which is characteristic of the indicated cell types. Therefore a complementary research interest of our lab is to understand whether and how ATAD3B regulates metabolism and its implications for stemness or tumor progression.
Thesis proposals
1. Role of ATAD3A in the regulation of mitochondrial ultrastructure, dynamics and mtDNA stability: implications for Mitochondrial Depletion Syndromes and Harel-Yoon disease
2. Exploring the ATAD3B role in lung cancer and chemoresistance.
3. Regulation of ATAD3B expression during embryogenesis: implications for cell pluripotency
4. Exploring the role of the TMEM65 mitochondrial protein in protein expression