Address book

Contacts

Staff Structures

MARIA RUZZENE

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Position

Professoressa Associata

Structure

Dipartimento di Scienze Biomediche - DSB

Address

VIA U. BASSI, 58/B - PADOVA

Telephone

0498276112

E-mail

maria.ruzzene@unipd.it

Notices

Office hours

  • at Dipertimento Scienze Biomediche, Via U. Bassi 58/b, 35131 Padova. IV piano Nord
    Su appuntamento

Teachings

Publications

Main publications of the last 4 years
1 Buontempo F, McCubrey JA, Orsini E, Ruzzene M, Cappellini A, Lonetti A, Evangelisti C, Chiarini F, Evangelisti C, Barata JT, Martelli AM. Therapeutic targeting of CK2 in acute and chronic leukemias. Leukemia. 2018 Jan;32(1):1-10.
2 Vilardell J, Girardi C, Marin O, Cozza G, Pinna LA, Ruzzene M. The importance of negative determinants as modulators of CK2 targeting. The lesson of Akt2 S131. PLoS One. 2018 Mar 1;13(3):e0193479.
3 Vilardell J, Alcaraz E, Sarró E, Trilla E, Cuadros T, de Torres I, Plana M, Ramón Y Cajal S, Pinna LA, Ruzzene M, Morote J, Meseguer A, Itarte E. Under-expression of CK2β subunit in ccRCC represents a complementary biomarker of p-STAT3 Ser727 that correlates with patient survival. Oncotarget. 2017 Dec 19;9(5):5736-5751.
4 Ruzzene M, Bertacchini J, Toker A, Marmiroli S. Cross-talk between the CK2 and AKT signaling pathways in cancer. Adv Biol Regul. 2017 Mar 28. pii: S2212-4926(17)30079-9.
5 Ottaviani D, Marin O, Arrigoni G, Franchin C, Vilardell J, Sandre M, Li W, Parfitt DA, Pinna LA, Cheetham ME, Ruzzene M. Protein kinase CK2 modulates HSJ1 function through phosphorylation of the UIM2 domain. Hum Mol Genet. 2017 Feb 1;26(3):611-623.
6 Marmiroli S, Fabbro D, Miyata Y, Pierobon M, Ruzzene M. Phosphorylation, Signaling, and Cancer: Targets and Targeting. Biomed Res Int. 2015;2015:601543.
7 Girardi C, Ottaviani D, Pinna LA, Ruzzene M. Different Persistence of the Cellular Effects Promoted by Protein Kinase CK2 Inhibitors CX-4945 and TDB. Biomed Res Int. 2015;2015:185736.
8 Kalathur M, Toso A, Chen J, Revandkar A, Danzer-Baltzer C, Guccini I, Alajati A, Sarti M, Pinton S, Brambilla L, Di Mitri D, Carbone G, Garcia-Escudero R, Padova A, Magnoni L, Tarditi A, Maccari L, Malusa F, Kalathur RK, A Pinna L, Cozza G, Ruzzene M, Delaleu N, Catapano CV, Frew IJ, Alimonti A. A chemogenomic screening identifies CK2 as a target for pro-senescence therapy in PTEN-deficient tumours. Nat Commun. 2015 Jun 18;6:7227.
9 Zanin S, Sandre M, Cozza G, Ottaviani D, Marin O, Pinna LA, Ruzzene M. Chimeric peptides as modulators of CK2-dependent signaling: Mechanism of action and off-target effects. Biochim Biophys Acta. 2015 Oct;1854(10 Pt B):1694-707.
10 Venerando A, Ruzzene M, Pinna LA. Casein kinase: the triple meaning of a misnomer. Biochem J. 2014 Jun 1;460(2):141-56.
11 Girardi C, James P, Zanin S, Pinna LA, Ruzzene M. Differential phosphorylation of Akt1 and Akt2 by protein kinase CK2 may account for isoform specific functions. Biochim Biophys Acta. 2014 Sep;1843(9):1865-74.
12 Cozza G, Girardi C, Ranchio A, Lolli G, Sarno S, Orzeszko A, Kazimierczuk Z, Battistutta R, Ruzzene M, Pinna LA. Cell-permeable dual inhibitors of protein kinases CK2 and PIM-1: structural features and pharmacological potential. Cell Mol Life Sci. 2014 Aug;71(16):3173-85.
13 Borgo C, Cesaro L, Salizzato V, Ruzzene M, Massimino ML, Pinna LA, Donella-Deana A. Aberrant signalling by protein kinase CK2 in imatinib-resistant chronic myeloid leukaemia cells: biochemical evidence and therapeutic perspectives. Mol Oncol. 2013 Dec;7(6):1103-15.