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MARTA MURGIA

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Position

Professoressa Associata

Address

VIA U. BASSI, 58/B - PADOVA

Telephone

0498276027

Title: Associate Professor of General Pathology
Institution: University of Padua

Education

- PhD in Molecular and Cellular Biology and Pathology
University of Padua, 1997
- Thesis: Calcium homeostasis in the cytosol and other cellular compartments
- Supervisor: Prof. T. Pozzan
- Coordinator: Prof. C. Montecucco


Professional Experience

- Associate Professor of General Pathology
School of Medicine, University of Padua

- Lecturer
University of Padua, since February 1999

- Post-Doctoral Scientist
Max Planck Institute of Biochemistry, Martinsried, Germany
- Department of Signal Transduction (Director: Prof. Axel Ullrich)
- October 2000 - January 2004
- EMBO Fellowship (2001-2002)
- Marie Curie Fellowship (2003-2004)

- Visiting Fellow
Max Planck Institute of Biochemistry, Martinsried, Germany
- Department of Proteomics and Signal Transduction (Director: Prof. Matthias Mann)
- April 2012 - March 2014
- Max Planck Society/Louis Jeantet Fellowship

- Collaborations
Collaboration with Prof. Matthias Mann’s proteomics group since 2014



External Institutional Activities

- Fellow, Max Planck Society
- Master Thesis Evaluator, Victoria University, Melbourne, Australia (August-October 2023)
- Career Evaluator, University College of London, 2025
- Selection Committee Member, various academic institutions


Dissemination Activities

- Contributions to guidelines for reopening sports facilities in Bavaria during COVID-19
- Published articles on exercise and COVID-19 and other relevant topics.
- Public lectures and mentoring for early career scientists



Teaching Activities

- Courses in General Pathology, Physiology, and Cell Biology
- Emphasis on program conceptualization, teaching strategies, and evaluation

- Mass Spectrometry-based Proteomics, Postgraduate School of Clinical Pathology



Research Activities

- Research on muscle physiology, metabolism, and signal transduction
- Specialization in proteomics of muscle fibers and human plasma
- Extensive experience in proteomics, bioinformatics, and molecular biology

- Key Publications:
- Murgia et al, EMBO Rep, 2015
- Murgia et al, PNAS Nexus, 2022



Reviewing and Grant Reviewing Activities

- Reviewer for several scientific journals, including:
- Scientific Reports, Communications Biology, Clinical Proteomics

- Grant Reviewer:
- Agence Nationale de la Recherche (ANR, France), Wellcome Trust

Notices

I carry out my research activity at both the Department of Biomedical Sciences in Padua and at the Max-Planck-Institute of Biochemistry in Martinsried, Germany. Any theses and thesis proposals will be based on scientific work in coordination between the two centres.

Office hours

  • Sempre tramite preavviso per email: marta.murgia@unipd.it. Modalita' a distanza.

Publications

Selected / last 10 years
Marta Murgia, Jörn Rittweger, Carlo Reggiani, Roberto Bottinelli, Matthias Mann, Stefano Schiaffino, Marco V. Narici (2024). Spaceflight on the ISS changed the skeletal muscle proteome of two astronauts. NPJ MICROGRAVITY, vol. Volume 10, ISSN: 2373-8065, doi: 10.1038/s41526-024-00406-3

Plasma proteome profiling of healthy subjects undergoing bed rest reveals unloading-dependent changes linked to muscle atrophy. Murgia M, Brocca L, Monti E, Franchi MV, Zwiebel M, Steigerwald S, Giacomello E, Sartori R, Zampieri S, Capovilla G, Gasparini M, Biolo G, Sandri M, Mann M, Narici MV. J Cachexia Sarcopenia Muscle. 2023 Feb;14(1):439-451.

Signatures of muscle disuse in spaceflight and bed rest revealed by single muscle fiber proteomics. Marta Murgia, Stefano Ciciliot, Nagarjuna Nagaraj, Carlo Reggiani, Stefano Schiaffino, Martino V Franchi, Rado Pišot, Boštjan Šimunič, Luana Toniolo, Bert Blaauw, Marco Sandri, Gianni Biolo, Martin Flück, Marco V Narici, Matthias Mann. PNAS Nexus, Volume 1, Issue 3, July 2022, pgac086,
HAX1-dependent control of mitochondrial proteostasis is essential for neutrophil granulocyte differentiation.
Fan Y, Murgia M, Linder MI, Mizoguchi Y, Wang C, Łyszkiewicz M, Ziȩtara N, Liu Y, Frenz S, Sciuccati G, Partida-Gaytan A, Alizadeh Z , Rezaei N, Rehling P , Dennerlein S, Mann M, Klein C*. J Clin Invest. 2022 May 2; 132(9):E153153.

Protein profile of fiber types in human skeletal muscle. A single fiber proteomics study.
Murgia M, Nogara L, Baraldo M, Reggiani C, Mann M, Schiaffino S. Skelet Muscle. 2021 Nov 2; 11(1):24

Proteomics of Cytochrome c Oxidase-Negative versus -Positive Muscle Fiber Sections in Mitochondrial Myopathy.
Murgia M, Tan J, Geyer PE, Doll S, Mann M, Klopstock T.
Cell Rep. 2019 Dec 17; 29(12):3825-3834.

SILAC-based quantitative proteomics using mass spectrometry quantifies endoplasmic reticulum stress in whole HeLa cells.
Itzhak DN, Sacco F, Nagaraj N, Tyanova S, Mann M, Murgia M. Dis Model Mech. 2019 Nov 11; 12(11).

Single Muscle Fiber Proteomics reveals Fiber-Type-Specific Features of Human Muscle Aging.
Murgia M, Toniolo L, Nagaraj N, Ciciliot S, Vindigni V, Schiaffino S, Reggiani C, Mann M. Cell Rep. 2017 Jun 13; 19(11):2396-2409.


Single muscle fiber proteomics reveals unexpected mitochondrial specialization
Murgia M, Nagaraj N, Deshmukh AS, Zeiler M, Cancellara P, Moretti I, Reggiani C, Schiaffino S, Mann M. EMBO Rep. 2015 Tue; 16(3):387-95.

Research Area

Mass Spectrometry-based proteomics of skeletal muscle
Proteomic analysis of mitochondrial disorders