Address book
Contacts
ENRICO MORO
Position
Professore Associato
Address
VIA A. GABELLI, 63 - PADOVA
Telephone
0498276341

Padova, March, 1996: Master degree in Biological Science (Biomolecular course) at the University of Padova (Italy)
Padova, May 1997: professional license as Biologist
December 2001 : PhD in Endocrine Sciences at the University of Ferrara (Italy).
March 2011-2017: Assistant Professor at the Department of Molecular Medicine, University of Padova (Italy).
October 2017-present: Associate Professor at the Department of Molecular Medicine, University of Padova (Italy).
July 2020-present Professional Habilitation to Full Professor (BIO/13- Cell Biology)
Working experiences in International Institutes:
- 2002-2003: Research Fellow, Dr. Shlomo Melmed Laboratory, Department of Endocrinology, Cedars Sinai Medical Center, Los Angeles (USA)
- 2006: Post-Doctoral training in” Transcriptomics and Proteomics in Zebrafish”, Leiden (Holland).
Author of 63 peer-reviewed international papers and more than 50 abstracts in national and international meetings.
Co-editor of two issues of the Journal of Endocrinological Investigation (2000).
Guest Editor for a special issue "Lysosomal Storage Disorders: Molecular Basis and Therapeutic Approaches" for Biomolecules
Member of the Editorial Board for Biomolecules
Invited Speaker in more than 15 national and international meetings. Cotutor and tutor for students of the Molecular Biology and Biotechnology courses.
Reviewer for Disease Models & Mechanisms, Osteoarthritis and Cartilage, , Journal of Steroid Biochemistry & Molecular Biology, PLOS One, Scientific Reports, Life Sciences, Journal of Neuroinflammation, International Journal of Developmental Neuroscience,J Molec Endocrinol.Cell & Tissue Research, Acta Neuropathol. Communication, Science Advances,Faseb Journal, J Clin Medicine, Biochimica Biophysica Acta (BBA), Frontiers Cell and Developmental Biology
Reviewer for National and Internaztional Projects: Cariplo, MRC/NC3Rs, MSD Foundation, U.S. – Israel Binational Science Foundation., ERC Consolidator, National Science Center (Poland)
-Lecturer at the School of Medicine for the six years cycle in Medicine and Surgery and in the School of Dentistry.
Research Grants
National
2010-2014 Progetto Giovani Ricercatori Ministero della Salute : Euros 355.000
2010-2012 and 2016-2018: University grant Junior fellowship 10000 Euros/year
2011-present :University grant 3000 euros /year
2015-2017 Co-investigator Cariparo Project Euros 265.000
2017-2018 University Grant Prid 2017 . 29000 euros
2021-2023 PRID 2021 c.a. 40000 euro
2024-2026 AISM c.a.100000 euro
2023-2025 PRIN -PRIN/PNRR c.a. 250000 euro
International
2012-2015 Genzyme Generation Program 2010. Euros 145.000
2015-2018 Genzyme Generation Program 2013. Euros 115.000
2019-2022 MPS society grant:140000 USD
Main research focus:
Analysis of lysosomal storage disorder pathogenesis, by means of in vitro and in vivo experimental models.
Notices
Office hours
Wednesday from 10:00 to 13:00
at III piano Nord -Ala scientifica- Dipartimento di Medicina Molecolare Complesso Vallisneri
Per qualsiasi chiarimento resto a disposizione anche in altri giorni della settimana
Publications
Last five years:
1) Roberto Costa, Roberta Peruzzo, Magdalena Bachmann, Giulia Dalla Montà, Mattia Vicario, Giulia Santinon, Andrea Mattarei, Enrico Moro, Ruben Quintana-Cabrera, Luca Scorrano, Massimo Zeviani, Francesca Vallese, Mario Zoratti, Cristina Paradisi, Francesco Argenton, Marisa Brini, Tito Calì, Sirio Dupont, Ildikò Szabò, Luigi Leanza. (2019) Impaired mitochondrial ATP production downregulates Wnt signaling via ER stress induction Cell reports. 28(8):1949-1960
2) Roberto Costa, Stefania Bellesso, Susanna Lualdi, Rosa Manzoli, Valeria Pistorio, Mirella Filocamo and Enrico Moro (corresponding author). (2020) A transcriptional and post-transcriptional dysregulation of Dishevelled 1 and 2 underlies the Wnt signaling impairment in type I Gaucher disease experimental models. Hum Mol Genet, 29(2) 274-285
3) Luca Guglielmi, Enrico Moro, Francesco Argenton, Lucia Poggi and Matthias
Carl (2020) A Wif1 mediated feedback loop suppresses premature Wnt signaling in nascent habenular neurons. Development Mar 16;147(6):dev182865 (IF=4.6)
4) Claudio D’Amore, Enrico Moro, Christian Borgo, Kenichiro Itami, Tsuyoshi Hirota, Lorenzo A. Pinna, Mauro Salvi. (2020) Janus” efficacy of CX-5011: CK2 inhibition and methuosis induction by independent mechanisms BBA –Mol Cell Res.
5) Rosa Manzoli, Lorenzo Badenetti, Michela Rubin and Enrico Moro (2021) Lysosomal function and axon guidance: is there a meaningful liaison? Biomolecules 11(2), pp. 1–14,
6) Enrico Moro. (2021) Lysosomal Storage Disorders: Molecular Basis and Therapeutic Approaches Biomolecules 2021, 11(7), 964;
7) Badenetti L, Manzoli R, Rubin M, Cozza G, Moro E. Monitoring Nrf2/ARE Pathway Activity with a New Zebrafish Reporter System. Int J Mol Sci. 2023 Apr 6;24(7):6804.
8) Badenetti L, Manzoli R, Trevisan M, D'Avanzo F, Tomanin R, Moro E. A novel CRISPR/Cas9-based iduronate-2-sulfatase (IDS) knockout human neuronal cell line reveals earliest pathological changes. Sci Rep. 2023 Jun 25;13(1):10289 (IF=4.6)
9) Giorgia Maria Ferlazzo, Anna Maria Gambetta, Sonia Amato, Noemi Cannizzaro,Silvia Angiolillo, Mattia Arboit, Linda Diamante, Elena Carbognin, Patrizia Romani, Federico La Torre, Elena Galimberti, Florian Pflug, Mirko Luoni, Serena Giannelli, Giuseppe Pepe, Luca Capocci, Alba Di Pardo, Paola Vanzani, Lucio Zennaro,Vania Broccoli, Martin Leeb, Enrico Moro, Vittorio Maglione and Graziano Martello. (2023) A genome-wide screening in pluripotent cells identifies Mtf1 as a novel suppressor of mutant huntingtin toxicity. Nature Communications 14(1):3962 (IF:16.6)
10) Gregorio I, Russo L, Torretta E, Barbacini P, Contarini G, Pacinelli G, Bizzotto D, Moriggi M, Braghetta P, Papaleo F, Gelfi C, Moro E, Cescon M. (2024) GBA1 inactivation in oligodendrocytes affects myelination and induces neurodegenerative hallmarks and lipid dyshomeostasis in mice. Mol Neurodegener. 7;19(1):22
11) Manzoli R, Badenetti L, Bruzzone M, Macario MC, Rubin M, Dal Maschio M, Roveri A, Moro E. (2024). Mucopolysaccharidosis type II zebrafish model exhibits early impaired proteasomal-mediated degradation of the axon guidance receptor Dcc. Cell Death Dis. 2024 Apr 16;15(4):269
12) Veroni C, Olla S, Brignone MS, Siguri C, Formato A, Marra M, Manzoli R, Macario MC, Ambrosini E, Moro E (co-corresponding author), Agresti C. (2024) The Antioxidant Drug Edaravone Binds to the Aryl Hydrocarbon Receptor (AHR) and Promotes the Downstream Signaling Pathway Activation. Biomolecules. 14(4):443
Research Area
- Characterization of the neuropathogenesis of lysosomal storage disorders (Gaucher, Hunter) using in vitro cell culture models and the experimental zebrafish model.
- Analysis of mechanisms regulating cell differentiation to develop pharmacological approaches for the treatment of human disorders
- Identification of therapeutic strategies for the treatment of multiple sclerosis using the zebrafish model.
Thesis proposals
- Analysis of CNS defects in type 1 Gaucher disease by in vitro and in vivo models
- Analysis of axonal and neuronal defects in type II Mucopolysaccharidosis by in vitro and in vivo models.
- Development of small molecules with neurotrophic and antioxidant activities
- Analysis of the complex interaction between oxidative stress and autophagy