Address book
Contacts
GIORGIA MIOLO
Position
Professoressa Associata
Address
VIA F. MARZOLO, 5 - PADOVA
Telephone
0498275705
Research Profile
1984, Laurea summa cum laude in Pharmaceutical and Technological Chemistry at the University of Padua.
1984 - 1985, fellow at the Department of Pediatrics of the University of Padua
1985-1988, fellow PhD in Pharmaceutical Sciences at the Department of Pharmaceutical Sciences in Padua:
1985 - 1986, visiting research scientist at the Department of Dermatology, Yale University, New Haven, USA.
1987, visiting research scientist at the Institute Curie, Section de Biologie, Paris, France
1989, Doctor in Pharmaceutical Sciences (PhD)
1989, Researcher at the Department of Pharmaceutical Sciences of Padua University
2006, Associate Professor at the Department of Pharmaceutical Sciences of Padua University
2022 Position: Associate Professor of Medicinal Analysis -Quantitative analysis of Medicines, University of Padova
2019-2023, Vice-President of International Union of Photobiology (IUPB),
2019-2025, Treasurer of the European Society for Photobiology (ESP),
2012 -2018, President of the Italian Society of Photobiology, Società Italiana di Fotobiologia (SIFB)
2023-2016 Referente di Ateneo nella Commissione per la Disabilità e l’Inclusione
Research activity
Mechanistic aspects of photosensitizing compounds in phototherapy, photoinduced drug toxicity and photostability. In particular: a) Photocytotoxic-photoantiproliferative activity of photosensitizing drugs in human tumour cell lines under UVA, Blue light and Red light; b) Photointeractions of phototherapeutics with biological substrates; c) Photostability studies: Photolysis of medicines and additives in vitro (in solution and in pharmaceutical formulation) under UVB, UVA and simulated solar light; characterization of the photoproducts. D) Stability and Photostability of Protein Drugs during their real-life.
2021-2024, PI for the 2020 Framework Programme Call: H2020-JTI-IMI2-2020-20-two-stage Project: 101007939 -RealHOPE - Handling of protein drug products and stability concerns.
Technical expertise
The experimental activity is focused on photobiology and photochemistry issues: the photoreactivity of drugs/illicit drugs and biological active compounds under selected wavelengths (UVA and UVB lamps) and solar light (sunlight simulator) in different matrices (solid, organic, aqueous solution, formulations); photosensitizing drug interactions, isolation and characterization of photoadducts with target substrates (salmon testes, calf thymus, plasmid- DNA, lipids, proteins, amino acids) and photodegradation products (UV-Vis spectroscopy, Fluorescence, LD-linear dichroism (DNA intercalating agents), Near and Far-UV Circular dichroism, Solid-Liquid chromatography (TLC, HPLC, UPLC), MS spectrometry (HRMS), DNA and protein electrophoresis (Native, PAGE), in vitro studies of phototoxic and photo-antiproliferative activity of compounds on human healthy or tumour cell cultures.
Publications
Author of more than 70 international papers and of more than 100 communications at international and national congresses. Editor and Author of the multi authored Book of RSC Comprehensive Series in Photochemical and Photobiological Sciences’ “Light in Forensic Science, Issues and Applications”, 2018; Editor of “Sensors”, Book of Proceedings of the Fourth National Conference on Sensors, Springer, 2019.
Reviewer activity
Photochemistry and Photobiology; Journal of Photochemistry and Photobiology, A; Journal of Photochemistry and Photobiology; Photochemical and Photobiological Sciences; Frontiers in Ph
Notices
Office hours
Monday from 11:30 to 12:30
at Dipartimento di Scienze del Farmaco, Edificio B, 2 piano piano stanza 32
In ogni caso la docente è disponibile a ricevere gli studenti oltre ai giorni e all' orario indicato, possibilmente previo appuntamento.Friday from 12:00 to 13:00
at Dipartimento di Scienze del Farmaco, Edificio B, 2 piano stanza 32
In ogni caso la docente è disponibile a ricevere gli studenti oltre ai giorni e all' orario indicato, possibilmente previo appuntamento.
Publications
PROFESSORE ASSOCIATO CONFERMATO
Università degli Studi di PADOVA
Facoltà: NESSUNA AFFERENZA
Dipartimento: SCIENZE DEL FARMACO - DSF
Tel: 0498275705, Fax: 0498275366
Email: GIORGIA.MIOLO@UNIPD.IT
Settore scientifico disciplinare 2024: CHEM-07/A Chimica farmaceutica
Gruppo scientifico disciplinare 2024: 03/CHEM-07 CHIMICA FARMACEUTICA, TOSSICOLOGICA, NUTRACEUTICO-ALIMENTARE, DELLE FERMENTAZIONI E DEI PRODOTTI PER IL BENESSERE E PER LA SALUTE
Papers Giorgia Miolo 2025-2020 Scopus list
Miolo, Giorgia, De Diana, Elisabetta, de Laureto, Patrizia Polverino, Realdon, Nicola, Rossi, Sergio, Rossi, Davide
Relationships between surface tensiometry properties and fluorescence intensity of dark and light exposed monoclonal antibody Nivolumab/Opdivo® by using the contact angle method: A pilot study
(2025) Journal of Pharmaceutical Sciences Volume 114, Issue 7July 2025 Article number 103823
DOI 10.1016/j.xphs.2025.103823
Rizzotto E., Inciardi I., Fongaro B., Trolese P., Miolo G., Polverino de Laureto P.
Light exacerbates local and global effects induced by pH unfolding of Ipilimumab
(2024) European Journal of Pharmaceutics and Biopharmaceutics, 201, art. no. 114387, Cited 1 times.
DOI: 10.1016/j.ejpb.2024.114387
Carpanese D., Rossi V., Di Paolo V., Quintieri L., Penna A., Zuccolotto G., Sebellin J., Saran C., Pipitone F., Miolo G., De Diana E., Realdon N., Rigamonti N., Di Sarra F., Coppola M., Rosato A.
Prolonging the stability of cetuximab (Erbitux®) and panitumumab (Vectibix®): An orthogonal assessment of physicochemical, biological and microbiological properties of original opened glass vials and diluted saline preparations
(2024) International Journal of Pharmaceutics, 649, art. no. 123643, Cited 4 times.
DOI: 10.1016/j.ijpharm.2023.123643
De Diana E., Rizzotto E., Inciardi I., Menilli L., Coppola M., Polverino de Laureto P., Miolo G.
Towards a better understanding of light-glucose induced modifications on the structure and biological activity of formulated Nivolumab
(2024) International Journal of Pharmaceutics, 654, art. no. 123926, Cited 2 times.
DOI: 10.1016/j.ijpharm.2024.123926
Cappelletto E., Kwok S.C., Sorret L., Fuentes N., Medina A.M., Burleigh S., Fast J., Mackenzie I.S., Fureby A.M., Paulsson M., Wahlgren M., Elofsson U., Flynn A., Miolo G., Nyström L., De Laureto P.P., De Paoli G.
Impact of Post Manufacturing Handling of Protein-Based Biologic Drugs on Product Quality and User Centricity
(2024) Journal of Pharmaceutical Sciences, 113 (8), pp. 2055 - 2064, Cited 4 times.
DOI: 10.1016/j.xphs.2024.05.027
Fongaro B., Campara B., Moscatiello G.Y., De Luigi A., Panzeri D., Sironi L., Bigini P., Carretta G., Miolo G., Pasut G., Polverino De Laureto P.
Assessing the physicochemical stability and intracellular trafficking of mRNA-based COVID-19 vaccines
(2023) International Journal of Pharmaceutics, 644, art. no. 123319, Cited 6 times.
DOI: 10.1016/j.ijpharm.2023.123319
Fongaro B., Cian V., Gabaldo F., De Paoli G., Miolo G., Polverino de Laureto P.
Managing antibody stability: Effects of stressors on Ipilimumab from the commercial formulation to diluted solutions
(2022) European Journal of Pharmaceutics and Biopharmaceutics, 176, pp. 54 - 74, Cited 8 times.
DOI: 10.1016/j.ejpb.2022.05.005
Barreca M., Ingarra A.M., Raimondi M.V., Spanò V., De Franco M., Menilli L., Gandin V., Miolo G., Barraja P., Montalbano A.
Insight on pyrimido[5,4-g]indolizine and pyrimido[4,5-c]pyrrolo[1,2-a]azepine systems as promising photosensitizers on malign
Research Area
1) study of the mechanism of action of furocoumarins and new photochemotherapeutic agents against DNA and other biological substrates (lipids and proteins);
2) study of the antiproliferative activity of photosensitizing compounds on human tumor cell lines;
3) isolation and characterization of the photocycloaddition products of photochemotherapeutic agents with the pyrimidine bases of DNA;
4) study of the specificity of photoreaction of such photochemotherapeutic agents with specific nucleotide sequences;
5) in vitro study of the phototoxic properties and mechanism of action of drugs that show photosensitizing effects in vivo (phototoxicity and photoallergy);
6) study of the stability of drugs to UVA and UVB light, which includes the characterization of the photoproducts that are formed with irradiation in vitro (solid state, aqueous and organic solutions, pharmaceutical forms) and ex vivo (porcine skin);
7) evaluation of toxicity and determination of the loss of pharmacological activity of the irradiated drug compared to the unchanged drug.
