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FRANCESCA MASTROTTO

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Position

Professoressa Associata

Address

VIA F. MARZOLO, 5 - PADOVA

Telephone

+390498275708

Francesca Mastrotto joined the Department of Pharmaceutical and Pharmacological Sciences at the University of Padova as junior lecturer in March 2017.
She received a Master degree in Pharmaceutical Chemistry and Technology in 2007 at the University of Padova and a PhD in Molecular Sciences, Pharmaceutical Sciences specialization, in 2011, at the same institution. During her PhD she participated in the Erasmus program spending 8 months at the School of Pharmacy, University of Nottingham (UK, 2010). After 18 months as postdoctoral researcher in the drug delivery group at the Department of Pharmaceutical and Pharmacological Sciences, University of Padova (2011-2012), she moved to the UK where she broadened her expertise carrying on, as research fellow, multidisciplinary research activities in the School of Pharmacy and the School of Life Science (2012-2017), at the University of Nottingham.
Her research focus areas include the design and synthesis of polymeric materials for a range of pharmaceutical applications, which span from smart drug delivery systems to immunotherapy.

Notices

Office hours

  • Tuesday from 9:00 to 11:00
    at Dipartimento di scienze del farmaco- edificio B- 2° piano - stanza 41
    si consiglia di concordare l'appuntamento con il docente via e-mail

Research Area

In recent years, polymer-based materials have attracted increased attention in the pharmaceutical field for a range of different applications, enabling the research community to develop, among others, innovative nanomedicine, drug delivery systems and immunomodulators. Synthetic polymers offer some advantages in term of availability and properties. In fact, it is possible to synthesise multi-gram scale batches, and their physical, chemical and biological properties can be easily tuned in a broad spectrum to match the requirements of specific applications. Francesca Mastrotto research interest is therefore focus on the generation of different types of polymers as tools to develop smart nanosystems able to selectively target cancer cells or bacteria. The projects deal both with the synthesis of the required materials, their physico-chemical characterisation, but also with the in vitro biological screening to assess their compatibility and efficacy.
In particular, in the last few years Francesca Mastrotto has been working on:
- engineering novel nanocarriers based on thermo- and pH-responsive polymers for either gold nanoparticles surface decoration or micelles and polymersomes assembly. These systems are thought to selectively target the tumour cell and release their cargo only at the site of the disease;
- synthetic polysaccharides, also called glycopolymers, to modulate the immune system;
- Synthetic polymers for nucletotides delivery.

Thesis proposals

Thesis projects are available within the research area. For further information please go to the section “Research Area” or arrange an appointment via email.