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Ricercatrice a tempo det. art. 24 c.3 lett. B L. 240/2010






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1. Gabbia D, et al. The Phytocomplex from Fucus vesiculosus and Ascophyllum nodosum Controls Postprandial Plasma Glucose Levels: An In Vitro and In Vivo Study in a Mouse Model of NASH. Mar Drugs. 2017 Feb 15;15(2). pii: E41. doi: 10.3390/md15020041. IF 5.118
2. Gabbia D, et al.. Pregnane X receptor and constitutive androstane receptor modulate differently CYP3A-mediated metabolism in early- and late-stage cholestasis. World J Gastroenterol. 2017 Nov 14;23(42):7519-7530. doi: 10.3748/wjg.v23.i42.7519. IF 5.742
3. Gabbia D, et al. Dexamethasone counteracts hepatic inflammation and oxidative stress in cholestatic rats via CAR activation. PLOS ONE, 2018, 2018 Sep 25;13(9):e0204336. doi: 10.1371/journal.pone.0204336. IF 3.240
4. Frión-Herrera Y, Gabbia D*, Díaz-García A, Cuesta-Rubio O, Carrara M. Chemosensitizing activity of Cuban propolis and nemorosone in doxorubicin resistant human colon carcinoma cells. Fitoterapia. 2019 Jul; 136:104173. doi: 10.1016/j.fitote.2019.104173. *corresponding author IF 2.882
5. Gabbia D, et al. Western Diet-Induced Metabolic Alterations Affect Circulating Markers of Liver Function before the Development of Steatosis. Nutrients. 2019 Jul 15;11(7):1602. doi: 10.3390/nu11071602. IF 5.717
6. Frión-Herrera Y, Gabbia D, Cuesta-Rubio O, De Martin S, Carrara M. Nemorosone inhibits the proliferation and migration of hepatocellular carcinoma cells. Life Sci. 2019 Oct 15;235:116817. doi: 10.1016/j.lfs.2019.116817. IF 5.037
7. Gabbia D, at al. Fucus vesiculosus and Ascophyllum nodosum Ameliorate Liver Function by Reducing Diet-Induced Steatosis in Rats. Mar Drugs. 2020 Jan 17;18(1):62. doi: 10.3390/md18010062. IF 5.118
8. Frión-Herrera Y, Gabbia D, Scaffidi M, Zagni L, Cuesta-Rubio O, De Martin S, Carrara M. The Cuban Propolis Component Nemorosone Inhibits Proliferation and Metastatic Properties of Human Colorectal Cancer Cells. Int J Mol Sci. 2020 Mar 6;21(5):1827. doi: 10.3390/ijms21051827. IF 5.923
9. Frión-Herrera Y, Gabbia D, Scaffidi M, Zagni L, Cuesta-Rubio O, De Martin S, Carrara M. Cuban Brown Propolis Interferes in the Crosstalk between Colorectal Cancer Cells and M2 Macrophages. Nutrients. 2020 Jul 9;12(7):2040. doi: 10.3390/nu12072040. IF 5.717
10. De Martin S, Gabbia D, Folli F, Bifari F, Fiorina P, Ferri N, Stahl S, Inturrisi CE, Pappagallo M, Traversa S, Manfredi PL. REL-1017 (Esmethadone) Increases Circulating BDNF Levels in Healthy Subjects of a Phase 1 Clinical Study. Front Pharmacol. 2021 Apr 28;12:671859. doi: 10.3389/fphar.2021.671859. IF 5.810
11. Gabbia D, Cannella L, De Martin S. The Role of Oxidative Stress in NAFLD-NASH-HCC Transition-Focus on NADPH Oxidases. Biomedicines. 2021 Jun 17;9(6):687. doi: 10.3390/biomedicines9060687. IF 6.081
12. Gabbia D, et al. The Extra Virgin Olive Oil polyphenol Oleocanthal exerts antifibrotic effects in the liver. Front. Nutr. doi: 10.3389/fnut.2021.715183 IF 6.576

Research Area

The main research is focused on the preclinical evaluation of new substances of natural origin to be used for the therapy of non-alcoholic fatty liver disease (NAFLD) and its complication, steatohepatitis (NASH) and of novel formulations for the treatment of hepatocellular carcinoma. To achieve this goal, we are studying three different approaches: 1) evaluating the efficacy of natural compounds on NAFLD/NASH, deepening the comprehension of the function of multiple dysfunctional pathways in the liver; 2) assessing the efficacy of brown algae extracts on NAFLD/NASH progression; 3) investigating the effect of polyphenols contained in extra virgin olive oil in the progression of NASH into hepatocellular carcinoma, investigating the involved mechanisms of action.

Thesis proposals

Pre-clinical and Clinical evaluation of novel agents for chronic liver disease.
Characterization of animal models of liver diseases, e.g. NAFLD/NASH, fibrosis and HCC, with a focus on their immune phenotyping
Availability of internship position: please contact