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Professore Associato





Assistant Professor of Pharmacology (tenure track)
University of Padova, Padova, Italy

Adjunct Professor
Department of Psychiatry
McGill University, Montreal, Canada

Project Leader
Division of Neuroscience
IRCSS San Raffael Hospital, Milan, IRCSS San Raffaele Hospital, Milano, Italy

2007-2009 Post-doctoral Fellow, Dept. of Pharmaceutical Sciences, Padova, Italy (Prof. C.V.L. Costa)
2009- June 2015 Post-doctoral Fellow, Dept of Psychiatry, McGill University, Montreal, Canada (Prof. G. Gobbi)
October 2015-September 2020 Assistant Professor of Pharmacology, San Raffaele Institute and Vita-Salute University,
Milan, Italy

2004 PhD Fellowship (Ministry of University and Scientific Research, Italy)
2007 Postdoctoral Fellowship, University of Padova, Padova, Italy
2008 Italian Chemistry Society-Mass Spectrometry Division, GlaxoSmithKline. Award to participate at the 5th MS
Pharmaday, Verona, Italy, October 27-29.
2009-2011 McGill University Health Center, McGill University, Montreal, Canada, Postdoctoral Fellowship
2015 2015 American Society of Clinical Psychopharmacology New Investigator Award
2017 Young Investigator Best Poster Award, 2017 World Federation of Biological Psychiatry Meeting in Copenhagen
2017 Brain & Behavior Research Foundation. NARSAD Young Investigator Grant
2018 Canadian Institute of Health Research, Early Career Researcher (ECR) Observer, Project Grant: Fall 2018

2016-to date American Society of Clinical Psychopharmacology (ASCP), Early Career Committee member
2019-to date International Society for Tryptophan Research (ISTRY), Executive Committee member
2020- to date American Society of Clinical Psychopharmacology (ASCP), Technology Task Force member

2010-now: Ministry of Health (Italy government), Grant Reviewer
2014: Netherlands Organization for Scientific Research: Grant reviewer
2014-now: Italian Ministry for Education, University and Research (MIUR): Grant reviewer
2017-now: University of Foggia, Italy. Intramural grants reviewer
2020-2021: European Union: ERA PerMed Joint Call; Grant Reviewer
2020 Austrian Science Fund (FWF), Programme Clinical Research (KLIF) 2020; Grant reviewer

2018-to date Editorial board member of Current Psychopharmacology
2019-to date Associate Editor, Frontiers in Pharmacology, Neuropharmacology section
2020-to date Editorial board member of Journal of Pineal Research (IF: 14.3)

Author of 83 publications (26 since 2019) in international peer-reviewed journals among which some with high impact including Nature Communications, PNAS, Neuropsychopharmacology, Journal of Pineal Research and Pharmacological Reviews.

Moreover, he co-authored more than 60 abstracts at national and international conferences.
H-index: 28, tot number of citations: 2039 (Scopus; March 25, 2022)


Office hours

  • su appuntamento previo accordo via email (


Author of more than 80 peer-reviewed manuscripts.

Selected publications last three years:

Repeated lysergic acid diethylamide (LSD) reverses stress-induced anxiety-like behavior, cortical synaptogenesis deficits and serotonergic neurotransmission decline.
De Gregorio D, Inserra A, Enns JP, Markopoulos A, Pileggi M, El Rahimy Y, Lopez-Canul M, Comai S, Gobbi G. Neuropsychopharmacology. 2022 in press

Lifetime Cannabis Use Disorder Is Not Associated With Lifetime Impulsive Behavior and Severe Violence in Patients With Schizophrenia Spectrum Disorders From a High-Security Hospital.
Comai S, Fuamba Y, Rivolta MC, Gobbi G. J Clin Psychopharmacol. 2021 Nov-Dec 01;41(6):623-628.

Inserra A, De Gregorio D, Rezai T, Lopez-Canul MG, Comai S, Gobbi G.
Lysergic acid diethylamide differentially modulates the reticular thalamus, mediodorsal thalamus, and infralimbic prefrontal cortex: An in vivo electrophysiology study in male mice. J Psychopharmacol. 2021Apr;35(4):469-482.

De Gregorio D, Popic J, Enns JP, Inserra A, Skalecka A, Markopoulos A, Posa L, Lopez-Canul M, Qianzi H, Lafferty CK, Britt JP, Comai S, Aguilar-Valles A, Sonenberg N, Gobbi G.
Lysergic acid diethylamide (LSD) promotes social behavior through mTORC1 in the excitatory neurotransmission. Proc Natl Acad Sci U S A. 2021 Feb 2;118(5):e2020705118.

Tassan Mazzocco M, Guarnieri FC, Monzani E, Benfenati F, Valtorta F, Comai S.
Dysfunction of the serotonergic system in the brain of synapsin triple knockout mice is associated with behavioral abnormalities resembling synapsin-related human pathologies. Prog Neuropsychopharmacol Biol Psychiatry. 2021 Mar 8;105:110135.

Wang Q, Zhu D, Ping S, Li C, Pang K, Zhu S, Zhang J, Comai S, Sun J.
Melatonin recovers sleep phase delayed by MK-801 through the melatonin MT2 receptor- Ca2+ -CaMKII-CREB pathway in the ventrolateral preoptic nucleus. J Pineal Res. 2020 Oct;69(3):e12674.

Nazzari S, Molteni M, Valtorta F, Comai S#, Frigerio A. # Corresponding author
Prenatal IL-6 levels and activation of the tryptophan to kynurenine pathway are associated with depressive but not anxiety symptoms across the perinatal and the post-partum period in a low-risk sample. Brain Behav Immun 2020 Oct;89:175-183.

Cambiaghi M, Buffelli M, Masin L, Valtorta F, Comai S. Transcranial direct current stimulation of the mouse prefrontal cortex modulates serotonergic neural activity of the dorsal raphe nucleus. Brain Stimul. 2020;13(3):548-550.

Comai S, De Gregorio D, Posa L, Ochoa-Sanchez R, Bedini A, Gobbi G.
Dysfunction of serotonergic activity and emotional responses across the light-dark cycle in mice lacking melatonin MT2 receptors. J Pineal Res. 2020 Apr 1:e12653.

Poletti S, Melloni E, Aggio V, Colombo C, Valtorta F, Benedetti F, Comai S.
Grey and white matter structure associates with the activation of the tryptophan to kynurenine pathway in bipolar disorder. J Affect Disord. 2019 Dec 1;259:404-412.

López-Canul M, Min SH, Posa L, De Gregorio D, Bedini A, Spadoni G, Gobbi G, Comai S.
Melatonin MT1 and MT2 Receptors Exhibit Distinct Effects in the Modulation of Body Temperature across the Light/Dark Cycle. Int J Mol Sci. 2019;20(10). pii: E2452.

De Gregorio D, McLaughlin RJ, Posa L, Ochoa-Sanchez R, Enns J, Lopez-Canul M, Aboud M, Maione S, Comai S, Gobbi G.
Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain.
Pain. 2019 Jan;160(1):136-150.

Thesis proposals

- Preclinical study of compounds that selectively act on melatonin receptors as new possible drugs for the treatment of psychiatric disorders such as depression, anxiety and autism.

- Study of the possible therapeutic activity of some psychedelics for the treatment of neurological disorders such as stroke.

-Study of the involvement of the serotonin/melatonin and kynurenine pathways in the neurobiology and psychopharmacology of psychiatric disorders such as depression, anxiety, autism and schizophrenia.