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MARCELLA CANTON

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Position

Professoressa Associata

Structure

Dipartimento di Scienze Biomediche - DSB

Address

CORSO STATI UNITI, 4 - PADOVA

Telephone

049 9640155

E-mail

marcella.canton@unipd.it

Current status: Associate Professor in Biochemistry (SSD BIO/10) in the Department of Biomedical Sciences, Faculty of Pharmacy (University of Padova)

1991: Graduated in Pharmaceutical Chemistry, University of Padova (110/110 cum laude).
1995: Ph.D. in Molecular and Cellular Biology and Pathology, Department of Biomedical Sciences, University of Padova
2006: Research Assistant in Biological Chemistry of the Faculty of Pharmacy, University of Padova

Research activity:
1989: C.E.E Erasmus Project fellowship at the Dept. of Organic Chemistry, University of Newcastle upon Tyne (UK); 1991/1995: PhD Training in Molecular and Cellular Biology and Pathology, University of Padova (tutor: Prof. Azzone) on the mechanisms of energy conversion in mitochondria and their alterations due to anahesthetics or hyperthyroidism; 1996/1997: research activity in the Laboratory of Biochemical Microbiology at GlaxoWellcome-Verona; 1997/2003: Post-doc fellowships, Dept of Biological Chemistry, University of Padova (supervisor: Prof Di Lisa). Study of the relationships between mitochondrial dysfunction and cell death; 1999: Dr. J. Van Eyk post-doctoral fellowship, Dept. of Physiology, Queen’s University, Kingston, Canada. Collaborative study on the identification of the oxidative modifications of the myofibrillar proteins; 2003/2005: post-doctoral fellowship FIRB-MIUR project n. RBAU0138CH, Dept. of Biological Chemistry, University of Padova (supervisor: Prof Di Lisa).
Research interest: oxidative modifications of myofibrillar proteins in ischemic myocardium and muscular dystrophy along with the mitochondrial sources of ROS.

Fundings:
2006-08: Responsible of the Ateneo Projects (Padova University).
2009-10: Responsible of a research grant from the Association francaise contre les myopathies
2009-11: Coordinator of the PRIN project: Role of monoamine oxidases and mitochondrial oxidative stress in the pathogenesis of muscular dystrophies and cardiac injury
2011-13: Responsible of a Junior fellowship (Padova University).
2014-2016: Co-responsible of a research sponsored by ZambonGroup
2018-2019: Responsible of a research grant from the Institute of Reseach Pediatric (IRP), Padova

Notices

Office hours

  • Monday from 10:00 to 12:00
    at Istituto di Ricerca Pediatrica Città della Speranza, Corso Stati Uniti 4, Padova o Complesso interdipartimentale Vallisneri, via u. Bassi 3
    Si prega di inviare una mail entro venerdi della settimana precedente per avere conferma

Teachings

Publications

Ten selected publications

1 Sánchez-Rodríguez R, Munari F, Angioni R, Venegas F, Agnellini A, Castro-Gil MP, Luisetto R, Castegna A, Viola A, Canton M (2020) Targeting monoamine oxidase to dampen NLRP3 inflammasome activation in acute and chronic inflammation. Cell Mol Immunol

2 Castegna A, Gissi R, Menga A, Montopoli M, Viola A, Canton M (2020) Pharmacological targets of metabolism in disease: opportunities from macrophages. Pharmacol. Ther.

3 Vitiello L, Marabita M, Sorato E, Nogara L, Forestan G, Mouly V, Salviati L, Acosta M, Blaauw B, Canton M (2018) Drug Repurposing for Duchenne Muscular Dystrophy: The Monoamine Oxidase B Inhibitor Safinamide Ameliorates the Pathological Phenotype in mdx Mice and in Myogenic Cultures from DMD Patients. Front. Physiol

4 Costiniti V, Spera I, Menabo R, Palmieri EM, Menga A, Scarcia P, Porcelli V, Gissi R, Castegna A, Canton M (2018) Monoamine oxidase-dependent histamine catabolism accounts for post-ischemic cardiac redox imbalance and injury. Biochim Biophys Acta Mol Basis Dis 1864:3050-9.

5 Nogara L, Naber N, Pate E, Canton M, Reggiani C, Cooke R (2016). Piperine's mitigation of obesity and diabetes can be explained by its up-regulation of the metabolic rate of resting muscle Proc Natl Acad Sci U S A 113(46):13009-13014.

6 Canton M, Menazza S, Sheeran F L, Polverino De Laureto P, Di Lisa F, And Pepe S (2011). Oxidation of myofibrillar proteins in human heart failure. J Am Coll Cardiol, 57 (3) 300-309.

7 Menazza S, Blaauw B, Tiepolo T, Toniolo L, Braghetta P, Spolaore B, Reggiani C, Di Lisa F, Bonaldo P, Canton M. (2010). Oxidative stress by monoamine oxidases is causally involved in myofiber damage in muscular dystrophy. Hum Mol Genet, 19; 4207-4215.

8 Caffieri S, Di Lisa F, Bolesani F, Facco M, Semenzato G, Dall'Acqua F, Canton M. (2007) The mitochondrial effects of novel apoptogenic molecules generated by psoralen photolysis as a crucial mechanism in PUVA therapy. Blood 109 (11), 4988-94.

9 Canton M, Skyschally A, Menabo R, Boengler K, Gres P, Schulz R, Haude M, Erbel R, Di Lisa F, Heusch G. (2006) Oxidative modification of tropomyosin and myocardial dysfunction following coronary microembolization. Eur Heart J, 27 (7), 875-81.

10 Chilin A, Dodoni G, Frezza C, Guiotto A, Barbieri V, Di Lisa F, Canton M. (2005) 4-Hydroxymethyl-1,6,8-trimethylfuro[2,3-h]quinolin-2(1H)-one induces mitochondrial dysfunction and apoptosis upon its intracellular oxidation. J Med Chem. 48 (1), 192-9.