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Professore Ordinario





G. Calo’ has a large experience in research with a broad background in the pharmacology of peptidergic systems. Since 1990 G. Calo’ has published > 300 papers (number of citations > 10000, H number 53) focused on peptide receptor pharmacology in particular in the fields of kinins, tachykinins, endothelins, opioids, nociceptin/orphanin FQ, urotensin II, and neuropeptide S. Several of these papers, particularly in the field of nociceptin/orphanin FQ and neuropeptide S, have been highly quoted placing them in the top 1% within their field: according to essential science indicators this demonstrated that the work summarized in those papers was highly influential and made a significant impact among scientists working in the field. G. Calo’ is also author of several patents on original ligands for GPCR and novel therapeutic indications for such ligands. Since 1999 G. Calo’ received research grants from different institutions at local, national, european, and international levels, and performed a large number of projects in collaboration with pharma industries.



Ten recent papers

1. Sturaro C, Malfacini D, Argentieri M, Djeujo FM, Marzola E, Albanese V, Ruzza C, Guerrini R, Calo' G, Molinari P. Pharmacology of Kappa Opioid Receptors: Novel Assays and Ligands. Front Pharmacol. 2022 Apr 21;13:873082.
2. Ding H, Trapella C, Kiguchi N, Hsu FC, Caló G, Ko MC. Functional Profile of Systemic and Intrathecal Cebranopadol in Nonhuman Primates. Anesthesiology. 2021 Sep 1;135(3):482-493.
3. Pacifico S, Albanese V, Illuminati D, Marzola E, Fabbri M, Ferrari F, Holanda VAD, Sturaro C, Malfacini D, Ruzza C, Trapella C, Preti D, Lo Cascio E, Arcovito A, Della Longa S, Marangoni M, Fattori D, Nassini R, Calò G, Guerrini R. Novel Mixed NOP/Opioid Receptor Peptide Agonists. J Med Chem. 2021 May 27;64(10):6656-6669.
4. Costanzini A, Ruzza C, Neto JA, Sturaro C, Malfacini D, Sternini C, De Giorgio R, Calò G. Pharmacological characterization of naloxegol: In vitro and in vivo studies. Eur J Pharmacol. 2021 Jul 15;903:174132.
5. Azevedo Neto J, Ruzza C, Sturaro C, Malfacini D, Pacifico S, Zaveri NT, Calò G. Functional Selectivity Does Not Predict Antinociceptive/Locomotor Impairing Potencies of NOP Receptor Agonists. Front Neurosci. 2021 Mar 30;15:657153.
6. Pacifico S, Ferrari F, Albanese V, Marzola E, Neto JA, Ruzza C, Calò G, Preti D, Guerrini R. Biased Agonism at Nociceptin/Orphanin FQ Receptors: A Structure Activity Study on N/OFQ(1-13)-NH2. J Med Chem. 2020 Oct 8;63(19):10782-10795.
7. Azevedo Neto J, Costanzini A, De Giorgio R, Lambert DG, Ruzza C, Calò G. Biased versus Partial Agonism in the Search for Safer Opioid Analgesics. Molecules. 2020 Aug 25;25(17):3870.
8. Ferrari F, Rizzo S, Ruzza C, Calo G. Detailed In Vitro Pharmacological Characterization of the Clinically Viable Nociceptin/Orphanin FQ Peptide Receptor Antagonist BTRX-246040. J Pharmacol Exp Ther. 2020 Apr;373(1):34-43.
9. Malfacini D, Simon K, Trapella C, Guerrini R, Zaveri NT, Kostenis E, Calo' G. NOP receptor pharmacological profile - A dynamic mass redistribution study. PLoS One. 2018 Aug 30;13(8):e0203021.
10. Calo' G, Rizzi A, Ruzza C, Ferrari F, Pacifico S, Gavioli EC, Salvadori S, Guerrini R. Peptide welding technology - A simple strategy for generating innovative ligands for G protein coupled receptors. Peptides. 2018 Jan;99:195-204.

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Research Area

Our lab is equipped to carry out in vitro receptor pharmacology experiments, particularly with G protein-coupled receptors (GPCRs). We employ molecular biology, cell biology, and pharmacological approaches to understand the pharmacological properties of ligands of such targets.

Thesis proposals

We are happy to host bachelor's and master's students for internships in advanced pharmacology of G protein-coupled receptors (GPCRs). We routinely employ molecular biology, cell biology, and in vitro pharmacology approaches to investigate the pharmacological properties of ligands acting at GPCRs.