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VIALE GIUSEPPE COLOMBO, 3 - VIA UGO BASSI, 58/B - PADOVA
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0498276058

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presso POLO MULTIFUNZIONALE A. VALLISNERI - Viale G. Colombo, 3 (pedonale) Via U. Bassi 58b (Carraio) 35121 PADOVA
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Insegnamenti
- PATOLOGIA GENERALE E MICROBIOLOGIA, AA 2025 (MEP4063586)
- SCIENZE DELLA PATOLOGIA UMANA E GENETICA MEDICA, AA 2025 (MEP9086500)
- PATOLOGIA GENERALE E MICROBIOLOGIA, AA 2024 (MEP4063586)
- SCIENZE DELLA PATOLOGIA UMANA E GENETICA MEDICA, AA 2024 (MEP9086500)
- PATOLOGIA GENERALE E MICROBIOLOGIA, AA 2023 (MEP4063586)
- SCIENZE DELLA PATOLOGIA UMANA E GENETICA MEDICA, AA 2023 (MEP9086500)
Pubblicazioni
La lista completa si trova qui: https://pubmed.ncbi.nlm.nih.gov/?term=marco+pirazzini&sort=date
Schiavone G, Richter S, Henke T, Koch I, Thies L, Klöpper F, Megighian A, Pirazzini M, Binz T. Probing the properties of PTEN specific botulinum toxin type E mutants. J Neural Transm (Vienna). 2025 Jan 23.
Motanova E, Pirazzini M, et al. Impact of ageing and disuse on neuromuscular junction and mitochondrial function and morphology: Current evidence and controversies. Ageing Res Rev. 2024 102:102586.
Machicoane M, Tonellato M, Zainotto M, Onillon P, Stazi M, Corso MD, Megighian A, Rossetto O, Le Doussal JM, Pirazzini M. Excitation-contraction coupling inhibitors potentiate the actions of botulinum neurotoxin type A at the neuromuscular junction. Br J Pharmacol. 2025 182(3):564-580.
Surana S, et al. The tyrosine phosphatases LAR and PTPRδ act as receptors of the nidogen-tetanus toxin complex. EMBO J. 2024 ;43(16):3358-3387.
Fabris F, Megighian A, Rossetto O, Simonato M, Schiavo G, Pirazzini M, Montecucco C. Local Tetanus Begins with a Neuromuscular Junction Paralysis around the Site of Tetanus Neurotoxin Release due to Cleavage of the Vesicle- Associated Membrane Protein. Am J Pathol. 2024 ;194(9):1752-1763.
Leka O, Wu Y, Zanetti G, Furler S, Reinberg T, Marinho J, Schaefer JV, Plückthun A, Li X, Pirazzini M, Kammerer RA. A DARPin promotes faster onset of botulinum neurotoxin A1 action. Nat Commun. 2023 ;14(1):8317.
Rossetto O, Pirazzini M, Montecucco C. Three players in the 'toxic affair' between botulinum neurotoxin type A and neurons. Trends Neurosci. 2023 46(9):695-697.
Fabris F, Varani S, Tonellato M, Matak I, Šoštarić P, Meglić P, Caleo M, Megighian A, Rossetto O, Montecucco C, Pirazzini M. Facial neuromuscular junctions and brainstem nuclei are the target of tetanus neurotoxin in cephalic tetanus. JCI Insight. 2023 8(11):e166978.
Marchioretti C, Zanetti G, Pirazzini M, et al. Defective excitation-contraction coupling and mitochondrial respiration precede mitochondrial Ca2+ accumulation in spinobulbar muscular atrophy skeletal muscle. Nat Commun. 2023 14(1):602
Pirazzini M, et al. Exceptionally potent human monoclonal antibodies are effective for prophylaxis and treatment of tetanus in mice. J Clin Invest. 2021 131(22):e151676.
Chivet M, Marchioretti C, Pirazzini M, et al. Polyglutamine-Expanded Androgen Receptor Alteration of Skeletal Muscle Homeostasis and Myonuclear Aggregation Are Affected by Sex, Age and Muscle Metabolism. Cells. 2020 9(2):325.
Zanetti G, Negro S, Megighian A, Mattarei A, Lista F, Fillo S, Rigoni M, Pirazzini M, Montecucco C. A CXCR4 receptor agonist strongly stimulates axonal regeneration after damage. Ann Clin Transl Neurol. 2019 6(12):2395-2402.
Zanetti G, Sikorra S, Rummel A, Krez N, Duregotti E, Negro S, Henke T, Rossetto O, Binz T, Pirazzini M. Botulinum neurotoxin C mutants reveal different effects of syntaxin or SNAP-25 proteolysis on neuromuscular transmission. PLoS
Pathog. 2017 13(8):e1006567.
Pirazzini M, Rossetto O, Eleopra R, Montecucco C. Botulinum Neurotoxins: Biology, Pharmacology, and Toxicology. Pharmacol Rev. 2017 69(2):200-235.
Rossetto O, Pirazzini M, Montecucco C. Botulinum neurotoxins: genetic,structural and mechanistic insights. Nat Rev Microbiol. 2014 12(8):535-49
Pirazzini et al. Thioredoxin and its reductase are present on synaptic vesicles, and their inhibition prevents the paralysis induced by botulinum neurotoxins. Cell Rep. 2014 8(6):1870-1878.