Address book

Contacts

Staff Structures

ROBERTA PROVVEDI

Back to the list

Position

Professoressa Associata

Structure

Dipartimento di Biologia - DiBio

Address

VIA U. BASSI, 58/B - PADOVA

Telephone

0498272346

E-mail

roberta.provvedi@unipd.it

ROBERTA PROVVEDI (RP), was born in Siena on November 29th 1967. Resident in Padova, (Italy)
Present position: Associate Professor of Microbiology (SSD BIO/19 - General Microbiology) at the Department of Biology, University of Padova.
She is a member of the Italian Society of General Microbiology and Microbial Biotechnology (SIMGBM).

Education

-1992. Bachelor in Biology
-1999. PhD in Microbiology

Professional activity

After her Bachelor Degree, RP has always been involved in studies on Microbiology. She worked at the Institute of Microbiology, Department of Molecular Biology, University of Siena (1992-1995). From 1995 to 2000 she worked first as a PhD STUDENT and then as a RESEARCH ASSOCIATE at the Public Health Research Institute of New York, NY, USA. In 2000 she was back in Siena and in 2002 she moved to the Department of Histology, Microbiology and Medical Biotechnology of the University of Padova. In 2006 she had a position as RESEARCH ASSOCIATE and from 2015 she is ASSOCIATE PROFESSOR in Microbiology (SSD BIO/19 – General Microbiology) at the Department of Biology, University of Padova

Teaching experience

Courses teached by RP:

2009/2010. APPLIED MICROBIOLOGY, degree in Health Biology, University of Padova
2011/present. MICROBIOLOGY, degree in Biology, University of Padova
2011/present. MICROBIOLOGY AND DIAGNOSTIC LABORATORY, degree in Health Biology, University of Padova

Notices

Teachings

Publications

Role of the Extracytoplasmic Function Sigma Factor SigE in the Stringent Response of Mycobacterium tuberculosis. Baruzzo G, Serafini A, Finotello F, Sanavia T, Cioetto-Mazzabò L, Boldrin F, Lavezzo E, Barzon L, Toppo S, Provvedi R, Manganelli R, Di Camillo B. Microbiol Spectr. 2023;11(2):e0294422. doi: 10.1128/spectrum.02944-22.
SigE: A master regulator of Mycobacterium tuberculosis. Manganelli R, Cioetto-Mazzabò L, Segafreddo G, Boldrin F, Sorze D, Conflitti M, Serafini A, Provvedi R. Front Microbiol. 2023;14:1075143. doi: 10.3389/fmicb.2023.1075143.
Transcriptional regulation and drug resistance in Mycobacterium tuberculosis. Miotto P, Sorrentino R, De Giorgi S, Provvedi R, Cirillo DM, Manganelli R. Front Cell Infect Microbiol. 2022; 12:990312. doi: 10.3389/fcimb.2022.990312.
LysX2 is a Mycobacterium tuberculosis membrane protein with an extracytoplasmic MprF-like domain.
Boldrin F, Cioetto Mazzabò L, Lanéelle MA, Rindi L, Segafreddo G, Lemassu A, Etienne G, Conflitti M, Daffé M, Garzino Demo A, Manganelli R, Marrakchi H, Provvedi R. BMC Microbiol. 2022; 22(1):85. doi: 10.1186/s12866-022-02493-2.
Tolerance and Persistence to Drugs: A Main Challenge in the Fight Against Mycobacterium tuberculosis.
Boldrin F, Provvedi R, Cioetto Mazzabò L, Segafreddo G, Manganelli R. Front Microbiol. 2020 ; 11:1924. doi: 10.3389/fmicb.2020.01924.
Improving the stability of the TetR/Pip-OFF mycobacterial repressible promoter system. Boldrin F, Anoosheh S, Serafini A, Cioetto Mazzabò L, Palù G, Provvedi R, Manganelli R. Sci Rep. 2019; 9(1):5783. doi: 10.1038/s41598-019-42319-2.
Assessing the role of Rv1222 (RseA) as an anti-sigma factor of the Mycobacterium tuberculosis extracytoplasmic sigma factor SigE. Boldrin F, Cioetto Mazzabò L, Anoosheh S, Palù G, Gaudreau L, Manganelli R, Provvedi R. Sci Rep. 2019; 9(1):4513. doi: 10.1038/s41598-019-41183-4.
Promoter mutagenesis for fine-tuning expression of essential genes in Mycobacterium tuberculosis.
Boldrin F, Degiacomi G, Serafini A, Kolly GS, Ventura M, Sala C, Provvedi R, Palù G, Cole ST, Manganelli R. Microb Biotechnol. 2018; 11(1):238-247. doi: 10.1111/1751-7915.12875.
The Alternative Sigma Factors SigE and SigB Are Involved in Tolerance and Persistence to Antitubercular Drugs. Pisu D, Provvedi R, Espinosa DM, Payan JB, Boldrin F, Palù G, Hernandez-Pando R, Manganelli R. Antimicrob Agents Chemother. 2017; 61(12):e01596-17. doi: 10.1128/AAC.01596-17.
lysX gene is differentially expressed among Mycobacterium tuberculosis strains with different levels of virulence. Montoya-Rosales A, Provvedi R, Torres-Juarez F, Enciso-Moreno JA, Hernandez-Pando R, Manganelli R, Rivas-Santiago B. Tuberculosis (Edinb). 2017; 106:106-117. doi: 10.1016/j.tube.2017.07.005.
Mapping and characterization of G-quadruplexes in Mycobacterium tuberculosis gene promoter regions.
Perrone R, Lavezzo E, Riello E, Manganelli R, Palù G, Toppo S, Provvedi R, Richter SN. Sci Rep. 2017 Jul 18;7(1):5743. doi: 10.1038/s41598-017-05867-z. PMID: 28720801 Free PMC article.
Essentiality of mmpL3 and impact of its silencing on Mycobacterium tuberculosis gene expression.
Degiacomi G, Benjak A, Madacki J, Boldrin F, Provvedi R, Palù G, Kordulakova J, Cole ST, Manganelli R. Sci Rep. 2017;7:43495. doi: 10.1038/srep43495.
Mycobacterium tuberculosis requires the ECF sigma factor SigE to arrest phagosome maturation.
Casonato S, Provvedi R, Dainese E, Palù G, Manganelli R. PLoS One. 2014 Sep 30;9(9):e108893. doi: 10.1371/journal.pone.0108893.

Research Area

RP has principally worked in the fields of bacterial genetics and global regulation of gene expression. At the beginning of her career, RP studied conjugative transposons of Gram positive bacteria and developed biotechnological tools with the commensal Streptococcus gordonii. From 1995 to 2000 she was in New York (USA). During this period her research focused on the characterization of the molecular mechanisms involved in natural transformation in the Gram positive bacterium Bacillus subtilis. When she moved to Padova, she started a research focused on Mycobacterium tuberculosis (Mtb) with main interest on the relationship between virulence and global regulation of transcription.

Thesis proposals

Role of SigE in the stringent response of Mycobacterium smegmatis and Mycobacterium tuberculosis