Address book
Contacts
LEONARDO NOGARA
Position
Ricercatore a tempo det. art. 24 c.3 lett. A L. 240/2010
Structure
Address
VIA F. MARZOLO, 3 - PADOVA
Telephone
Notices
Grants:
2025-2027
SID DSB Unipd (€ 20000)
Title: “Connecting myosin Super Relaxed State modulation to oxygen consumption: a time
course study of skeletal muscle basal metabolism following contraction”
2023-2025
SID DSB Unipd (€ 37889)
Title: “Contractility and metabolics properties of ex-vivo skeletal muscle as a function of piperine derivatives fiber type selectivity.”
2022-2024
SUPPORTING TALENT IN RESEARCH @ UNIVERSITY OF PADUA Starting Grant (€ 180000)
Title: “The pathophysiology of the Super Relaxed state of myosin in skeletal muscle”
2022-2023
AFM Telethon Trampoline Grant 2022 (€ 50000)
Title: “Pharmacological regulation of the OFF state of myosin in skeletal muscle”
Office hours
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Teachings
HUMAN PHYSIOLOGY, AA 2025 (MEN1035110)
HUMAN PHYSIOLOGY, AA 2024 (FAM1027519)
Publications
Selected publications:
1. Mauro Montesel, Cosimo De Napoli, Luisa Schmidt, Elena Germinario, Ulises Guzmán, Jesper V. Olsen, Lorenzo Marcucci, and Leonardo Nogara. 2025. A combined experimental and computational analysis of mantATP turnover in skinned muscle fibers. PNAS (doi: 10.1073/pnas.2502652122)
2. Nogara L, Germani S, De Napoli C, Blaauw B, Zito E. Protocol for measuring force in skinned diaphragm muscle fibers of myopathic SEPN1 knockout mice following chronic tauroursodeoxycholic acid treatment. STAR Protoc. 2025;6(3):103918.
3. De Napoli C, Schmidt L, Montesel M, Cussonneau L, Sanniti S, Marcucci L, Germinario E, Kindberg J, Evans AL, Gauquelin-Koch G, Narici M, Bertile F, Lefai E, Krüger M*, Nogara L*, Blaauw B.* 2025. Reduced ATP turnover during hibernation in relaxed skeletal muscle. Nat Commun 16:80. doi:10.1038/s41467-024-55565-4
4. Giulio Masiero, Giulia Ferrarese, Eleonora Perazzolo, Martina Baraldo, Leonardo Nogara* and Caterina Tezze*. Custom-made 3D-printed boot as a model of disuse-induced atrophy in murine skeletal muscle. PLOS ONE (2024).
5. M. Murgia, L. Nogara (co-first author), M. Baraldo, C. Reggiani, M. Mann, S. Schiaffino, Protein profile of fiber types in human skeletal muscle: a single-fiber proteomics study. Skelet. Muscle. 11, 24 (2021).
6. F. Solagna, L. Nogara (co-first author), K. A. Dyar, F. Greulich, A. A. Mir, C. Türk, T. Bock, A. Geremia, M. Baraldo, R. Sartori, J. Farup, H. Uhlenhaut, K. Vissing, M. Kruger, B. Blaauw, Exercise-dependent increases in protein synthesis are accompanied by chromatin modifications and increased MRTF-SRF signaling. Acta Physiol. Oxf. Engl. (2020), doi:10.1111/apha.13496.
7. L. Nogara, N. Naber, E. Pate, M. Canton, C. Reggiani, R. Cooke, Piperine’s mitigation of obesity and diabetes can be explained by its up-regulation of the metabolic rate of resting muscle. Proc. Natl. Acad. Sci. 113, 13009–13014 (2016).
8. L. Nogara, N. Naber, E. Pate, M. Canton, C. Reggiani, R. Cooke, Spectroscopic Studies of the Super Relaxed State of Skeletal Muscle. PLOS ONE. 11, e0160100 (2016).
Research Area
Skeletal muscle
Muscle physiology
Myosin
Super Relaxed State
Basal metabolism
Thesis proposals
Myosin is the main motor protein in skeletal muscle, its structure and dynamics in relaxed tissue strongly affect whole-body basal metabolism. This specific mechanism has recently been unveiled and its physiological and pathological implications are yet to be identified. In our lab we apply biochemical and biophysical techniques to study myosin resting states and their impact over physiological processes.
