Address book
Contacts
GUALTIERO ALVISI
Position
Professore Associato
Address
VIA A. GABELLI, 63 - PADOVA
Telephone
0498272353
Gualtiero Alvisi obtained his PhD Molecular and Cellular Biotechnologies from Bologna University, Italy in 2005. During is PhD and his subsequent PostDoctoral studies he worked for 3 years at the Department of Biochemistry and Molecular Biology at Monash University (Clayton, Victoria, Australia).
In 2007, he returned University of Bologna to continue his studies on Herpesviridae DNA polymerases.
In 2009 he moved to University of Heidelberg to join the group of Prof. Ralf Bartenchlager at the Department of Molecular Virology and study the relationship between Dengue and Hepatitis C Virus and the host cell, focusing on the identification of host factors important for viral replication and lipid metabolism.
From 2011 to 2021 he worked as an Assistant Professor of Microbiology at University of Padua where he moved to establish his own research group at the Department of Molecular Medicine (http://gualtax.wixsite.com/alvisilab; orcid: https://orcid.org/0000-0002-8177-3616).
From 2021 he is an Associate Professor at the same Department.
The focus of Gualtiero's research is the relationship between infectious agents and infected cells, with particular attention to protein-protein interactions allowing virus replication and promoting disease establishment.
Research interests include:
1) The relationship between infectious agents and infected cells, with particular attention to protein-protein interactions that allow virus replication and promote the development of diseases
2) The role of nucleocytoplasmic transport in human pathologies (infections, cancer, neurodegenerative diseases)
3) Treatment of genetic diseases using genome editing approaches
Current projects include:
1) identification of small molecules that destroy protein-protein interactions important for the replication of the human cytomegalovirus
2) development of cellular probes to detect viral prosthesis activity in order to monitor the life cycle of important human pathogens and to identify new antiviral drugs.
3) The study of the molecular bases responsible for the regulation and specificity of nuclear transport, using viral and cellular proteins as a model, with particular attention to factors involved in the replication and modulation of the functionality of the host cell by human pathogenic viruses
Gualtiero collaborates with research groups within Italy (University of Bologna, University of Modena, University of Brescia, University of Milan) and internationally (Australia: Monash University, Canberra University, Wagga Wagga University) and his research is funded by PRIN and University of Padua research grants.
He is author of 50 scientific publications in peer-reviewed Journals, including Nature, Cell Host and Microbe, Antiviral Research, Journal of Virology and FASEB, as well as two book chapters (google scholar citations: 1856, h-index: 25).
Gualtiero is also deeply involved in peer reviewing (https://publons.com/author/272395/gualtiero-alvisi#profile), being an Editor for Scientific Reports, Frontiers in Microbiology, Cells and PLOS ONE, and having reviewed for several Journals including Journal of Virology, Journal of Physiology, Biochemistry, Traffic, Analytical Chemistry and many other Journals.
Notices
Office hours
Monday from 12:00 to 13:00
at Via Aristide Gabelli 63, Padova
Contattare telefonicamente il docente per concordare un colloquio con almeno 7 giorni di anticipo
Teachings
- MICROBIOLOGY, AA 2024 (MEP5071038)
- MICROBIOLOGY, AA 2023 (MEP5071038)
- MICROBIOLOGY, AA 2022 (MEP5071038)
- LABORATORY ACTIVITIES 1: CELLULAR AND MOLECULAR THERAPIES, AA 2021 (MEP7079237)
- LABORATORY ACTIVITIES 1: CELLULAR AND MOLECULAR THERAPIES, AA 2021 (MEP7079237)
- MICROBIOLOGY, AA 2021 (MEP5071038)
- LABORATORY ACTIVITIES 1: CELLULAR AND MOLECULAR THERAPIES, AA 2020 (MEP7079237)
- LABORATORY ACTIVITIES 1: CELLULAR AND MOLECULAR THERAPIES, AA 2020 (MEP7079237)
- MICROBIOLOGY, AA 2020 (MEP5071038)
- LABORATORY ACTIVITIES 1: CELLULAR AND MOLECULAR THERAPIES, AA 2019 (MEP7079237)
- MICROBIOLOGY, AA 2019 (MEP5071038)
- HOW TO WRITE A SCIENTIFIC PAPER, A POSTER AND A THESIS FOR BACHELOR DEGREE, AA 2015 (MEP3053066)
- MICROBIOLOGY, VIROLOGY AND PARASSITOLOGY APPLIED TO MEDICINE, AA 2015 (MEN1036443)
- HOW TO WRITE A SCIENTIFIC PAPER, A POSTER AND A THESIS FOR BACHELOR DEGREE, AA 2014 (MEP3053066)
- MICROBIOLOGY, VIROLOGY AND PARASSITOLOGY APPLIED TO MEDICINE, AA 2014 (MEN1036443)
- APPLIED MICROBIOLOGY AND GENETIC ENGINEERING, AA 2012 (SCO2045392)
- TARGETED DNA MUTAGENESIS FOR THE CURE OF CHRONIC VIRAL INFECTIONS, AA 2012 (MEO2046675)
- TARGETED DNA MUTAGENESIS FOR THE CURE OF CHRONIC VIRAL INFECTIONS, AA 2012 (MEO2046675)
Research Area
Interniship positions are available in the following topics
* Development of antiviral drugs and characterization of the mechanism of action with particular attention to inhibitors of protein-protein interactions, inhibitors of prostheses and inhibitors of nucleocytoplasmic transport
* Characterization of BRET cell probes as sensors of viral protein activity
* Characterization of the role of nucleocytoplasmic transport of viral proteins for the replication and pathogenesis of viral infections
Thesis proposals
* Development of antiviral drugs and characterization of the mechanism of action with particular attention to inhibitors of protein-protein interactions, inhibitors of prostheses and inhibitors of nucleocytoplasmic transport
* Characterization of BRET cell probes as sensors of viral protein activity
* Characterization of the role of nucleocytoplasmic transport of viral proteins for the replication and pathogenesis of viral infections
Students will learn the following methods
* cell culture
* molecular cloning, PCR, cloninig gateway, restriction profile analysis
* Western Blotting
* Immunofluorescence
* FACS
* Quantitative analysis of data
* BRET
* FRET
* Laser Confocal Microscopy
* Live cell imaging