Cannabinology: The Cannabis Plant and the Endocannabinoid System
Lifelong Learning Course
Scientific Coordinator: Gastone Zanette
Dates: from 23 October 2023 to 28 February 2024. 28.5 hours of recorded video lessons, in-depth readings and tests (Since the lessons are recorded videos, the student will be able to access and follow the lessons during the entire opening period of the course, at any time)
Registration deadline: 30 September 2023
Goals:
- Learn the ethnobotanical and ethno-pharmacological characteristics of the Cannabis sativa L. plant, for its use in the various pharmaceutical and medicinal, agro-industrial and food fields;
- Learn the evolutionary history of the Endocannabinoid System, its functions, and the pathophysiology of endocannabinoid deficiency or overproduction;
- Learn the clinical evaluation of the patient and the risk associated with particular pathological pictures in relation to the possible therapeutic uses of Medicinal Cannabis (CM);
- Learn the regulations governing the cultivation, production, prescription and dispensing of CM;
Target audience: Doctors, pharmacists, chemists, CTFs, biologists, agronomists, pharmacologists, laboratory and analysis technicians; Secondary: entrepreneurs.
Training Methods: FAD (distance learning): video lessons delivered in asynchronous mode, written interaction with teachers in case of doubts and questions from the student.
Enrolment fee: 900 €
How to enrol: To enrol in the course, connect to the website https://apex.cca.unipd.it/pls/apex/f?p=308:2::::2:P_MERCHID,P_LANG:252,ITA
The payment of the fee is required in a single form. The fee will be refundable only in case of non-start of the course due to failure to reach the minimum number of 5 participants - maximum 50 participants.
For information:
- Mara Salerno, University of Padova: mara.salerno@unipd.it;
- Prof. Gastone Zanette, University of Padova: gastone.zanette@unipd.it, +39 339 6982231
- Andrea Cristofoletto, Cannabiscienza: andrea@cannabiscienza.it, +39 375 5058303
Course Facilities: E-learning platform cannabiscienza.it by Cannabiscienza Srl; the University will receive instructions from Cannabiscienza to be forwarded to participants to register on the aforementioned platform and access the contents; the scientific coordinator Prof. G. Zanette will receive an administrator access to the control panel.
Teachers:
University Professors: Gastone Zanette; Stefano Bona; Stefano Dall'Acqua
Retired professors of the University: Enrico Facco
External lecturers:
- Davide Fortin - Bursar - Center d'Economie de la Sorbonne
- Annarita Eva - Social Communications - Cannabiscienza
- Federica Pollastro - Medicinal Chemistry - University of Eastern Piedmont
- Viola Brugnatelli - Neuroscientist - Cannabiscienza
- Luigi Romano - Biologist - Cannabiscienza
- Giorgio Faggiana - Biologist - Military Pharmaceutical Institute
- Lorenzo Calvi - Surgeon - Cannabiscienza
- Livio Luongo - Pharmacologist - University of Campania Vanvitelli
- Massimiliano D'Imperio - Biologist nutritionist - CNR Alimentazione Bari
- Marco Ternelli - Pharmacist galenist
- Arno Hazekamp – Biochemist – Cannabiscienza
Syllabus:
MODULE 1 - AGRO-PRODUCTIVE AND BOTANICAL ASPECTS
- Origin, evolution and botany of Cannabis S (L. Romano)
- Biosynthesis of phytocannabinoids (V. Brugnatelli)
- Decarboxylation and oxidation (F. Pollastro)
- THC and CBD: S. Cannabis varieties from around the world and in Italy (L. Romano)
- Cannabis: botany, propagation and cultivation techniques (S. Bona)
- Genetic characteristics: Chemotype variations and metabolomics (G. Faggiana)
- Manufacturing in Good Manufacturing Process (GMP) (A. Hazekamp)
MODULE 2 - LEGAL AND SOCIAL ASPECTS
- History and Anthropology of Cannabis: Homo Sapiens and Cannabis. Medicinal Cannabis from Prehistoric Times to the Present Day. The study of CM over the centuries, scientific societies and patient associations (G. Zanette)
- Placebo and nocebo effect. The mind-brain-reality relationship (E. Facco)
- Cannabis: A Guide to Creative Experiences and Support for Raising Awareness (A. Eva)
- Italian law: Cannabis as a drug (L. Romano)
- How CM prescription works in Italy (L. Calvi)
- CM: economic aspects (D. Fortin)
MODULE 3 – THE ENDOCANNABINOID SYSTEM
- Evolution and functions of the Endocannabinoid System (V. Brugnatelli)
- CB1 and CB2 receptors (L. Luongo)
- CB2 and neuropathic pain (L. Luongo)
- Other receptors of the Endocannabinoid System (V. Brugnatelli)
- Endocannabinoids and the Enzyme System (L. Luongo)
- The microbiota and the EC System (L. Luongo)
MODULE 4 - CLINICAL ASPECTS
- CM in clinical practice: Medicinal uses of cannabis (V. Brugnatelli); The varieties of CM that can be prescribed in Italy (Calvi L); Principles of pharmacokinetics applied to CM (Brugnatelli V.); Routes of administration (Calvi L.)
- Medicinal uses of THC (L. Luongo)
- Medicinal uses of CBD in algology, rheumatology and endocrinology (V. Brugnatelli); Medicinal uses of CBD in neurology and psychiatry (V. Brugnatelli); CBD cream for autoimmune encephalomyelitis (F. Pollastro)
- History of the entourage effect (V. Brugnatelli); Approach to personalized medicine (V. Brugnatelli); Personalized Medicine in Clinical Practice (L. Calvi)
- Dosages and contraindications (Biphasic effects of cannabinoids (Pollastro F.); Titration of CM (Calvi L.); Tolerance, sensitization and dependence (Calvi L.); Contraindications, Pharmaceutical Interactions, and Side Effects (Calvi L.)
MODULE 5: - PHARMACEUTICAL AND FOOD ASPECTS
- Cannabis: phytochemistry and analytical techniques (S. Dall'Acqua)
- Lab practice: HPLC analysis of CM (M. Ternelli)
- Cannabis for food use (M. D'Imperio)
- Solubility of cannabinoids and solvent choice (F. Pollastro)
- Galenic methods and preparations (Romano L.)
- CM in pharmacy (M. Ternelli)
- Comparison of CBD oleolites (Calvi L.)
Lifelong Learning Courses