Address book

Contacts

Staff Structures

LIBERO VITIELLO

Back to the list

Position

Professore Associato

Structure

Dipartimento di Biologia - DiBio

Address

VIALE GIUSEPPE COLOMBO, 3 - VIA UGO BASSI, 58/B - PADOVA

Telephone

0498276212

E-mail

libero.vitiello@unipd.it

LIBERO VITIELLO, Curriculum Vitae


Present address: Department of Biology
University of Padova
e-mail: libero.vitiello@bio.unipd.it


Education
Jul. 1988: Degree in Biological Sciences, University of Padova, final evaluation: Summa cum Laude. Title of the thesis: "Deletion mutations of the DMD-BMD locus: screening by molecular intragenic probes”.
Nov. 1989 to Sept. 1993: Ph.D. student in the “Genetic Sciences” joint program between University of Ferrara and University of Padova. Title of the thesis: "Mutation analysis in coding and regulative sequences of the human dystrophin gene”.

Professional experience
Nov. 1993 to Dec. 1996: Post-Doctoral fellow in Dr. Ron Worton laboratory at the Department of Genetics of the Hospital for Sick Children (Toronto), working on the project "Liposome-mediated gene therapy of Duchenne Muscular Dystrophy". Collaboration, involving frequent visits, with the Liposome Research Unit of the University of British Columbia and with INEX Pharmaceuticals Inc., Vancouver.
Dec. 1996 to Sept 1998: Researcher funded by Telethon Italia, at the Center for Innovative Biotechnologies of the University of Padua.
Sept 1998 to present: Researcher and Assistant Professor at the University of Padova, working at the Department of Biology.
Aug 2013 to Sept 2014: Visiting Scientist at the Institute for Biomaterials and Biomedical Engineering of the University of Toronto.

Present research activity
Study of macrophage-produced myogenic factors in relation to skeletal muscle regeneration/repair, isolation and expansion of myogenic stem cells in vitro and to down-regulate adipogenesis in diseased muscle.
Study of anti-MAO molecules as therapeutic agents in Duchenne muscular dystrophy (Collaboration with Dr. Marcella Canton and Prof. Bert Blaauw, University of Padova).
Use of in vivo murine models to study the pathogenic mechanisms of causative mutations in inherited Arrhythmogenic Cardiomyopathy (collaboration with Dr. Alessandra Rampazzo, University of Padova).

Collaboration with Dr. Carlo Nobile (CNR Italy) to study the functional effects of causative mutations in a type of inherited epilepsy
Collaboration with Dr. Penney Gilbert (University of Toronto) to create in vitro 3D models of human skeletal muscle.
Pre-clinical trial on anti-inflammatory molecules in dystrophic muscle (Dr. Luisa Gorza, University of Padova).
Collaboration with Dr. Cesare Gargioli, University of Rome and Dr. Francesco Fascetti Leon (University of Padova) to create 3D muscle construct for the correction of congenital ano-rectal malformations.

Notices

Office hours

  • at Dipartimento di Biologia, Complesso Vallisneri, secondo piano sud stanza 5
    Gli appuntamenti vanno concordati preventivamente via email

Teachings

Publications

1. Vitiello L, Marabita M, Sorato E, Nogara L, Forestan G, Mouly V, Salviati L, Acosta M, Blaauw B, Canton M. Drug Repurposing for Duchenne Muscular Dystrophy: the Monoamine Oxidase B Inhibitor Safinamide Ameliorates the Pathological Phenotype in mdx Mice and in Myogenic Cultures from DMD Patients. Submitted (upon invitation) to Frontiers in Physiology, Integrative Physiology Section, on April 13th, 2018.

2. Testa S, Fuoco C, Costantini M, Belli R, Fascetti Leon F, Vitiello L, Rainer A, Cannata S, Gargioli C. Designing a 3D printed human derived artificial myo-structure for anal sphincter defects in anorectal malformations and adult secondary damage. Materials Today Communications, 2018; 15: 120-123. doi.org/10.1016/j.mtcomm.2018.02.011.

3. Tedesco S, De Majo F, Kim J, Trenti A, Trevisi L, Fadini GP1, Bolego C, Zandstra PW, Cignarella A, Vitiello L. Convenience versus Biological Significance: Are PMA-Differentiated THP-1 Cells a Reliable Substitute for Blood-Derived Macrophages When Studying in Vitro Polarization? Front Pharmacol. 2018 Feb 22;9:71. doi: 10.3389/fphar.2018.00071. eCollection 2018.

4. L. Vitiello, A. Manzini. Implicanze bioetiche dell'ingegneria genetica: i test genetici. C. Viafora, E. Furlan, S. Tusino (a cura di), A lezione di bioetica. Temi e strumenti, terza edizione, FrancoAngeli, Milano (2018, in press)

5. Vianello S, Pantic B, Fusto A, Bello L, Galletta E, Borgia D, Gavassini BF, Semplicini C, Sorarù G, Vitiello L, Pegoraro E. SPP1 genotype and glucocorticoid treatment modify osteopontin expression in Duchenne muscular dystrophy cells. Hum Mol Genet. 2017 Sep 1;26(17):3342-3351. doi: 10.1093/hmg/ddx218.

6. Dazzo E, Leonardi E, Belluzzi E, Sandro Malacrida, Libero Vitiello, Elisa Greggio, Silvio C. E. Tosatto, Carlo Nobile. (2016) Secretion-Positive LGI1 Mutations Linked to Lateral Temporal Epilepsy Impair Binding to ADAM22 and ADAM23 Receptors. PLoS Genet 12(10): e1006376. doi:10.1371/journal.pgen.1006376

7. Pigozzo SR, Da Re L, Romualdi C, Mazzara PG, Galletta E, Fletcher S, Wilton SD, Vitiello L. (2013) Revertant Fibers in the mdx Murine Model of Duchenne Muscular Dystrophy: An Age- and Muscle-Related Reappraisal. PLoS ONE 8(8): e72147. doi:10.1371/journal.pone.0072147

8. Vallese D, Negroni E, Duguez S, Ferry A, Trollet C, Aamiri A, Vosshenirch CA, Füchtbauer EM, Di Santo JP, Vitiello L, Butler-Browne G, Mouly V. (2013) The Rag2-Il2rb-Dmd- mouse: a novel dystrophic and immunodeficient model to assess innovating therapeutic strategies for muscular dystrophies. Mol Ther. 2013 Oct;21(10):1950-7.

9. Occhi G, Losa M, Albiger N, Trivellin G, Regazzo D, Scanarini M, Monteserin-Garcia JL, Fröhlich B, Ferasin S, Terreni MR, Fassina A, Vitiello L, Stalla G, Mantero F, Scaroni C. (2011) The glucose-dependent insulinotropic polypeptide receptor is overexpressed amongst GNAS1 mutation-negative somatotropinomas and drives growth hormone (GH)-promoter activity in GH3 cells. J Neuroendocrinol. 23:641-9

10. Rossi CA, Flaibani M, Blaauw B, Pozzobon M, Figallo E, Reggiani C, Vitiello L, Elvassore N, De Coppi P. (2011) In vivo tissue engineering of functional skeletal muscle by freshly isolated satellite cells embedded in a photopolymerizable hydrogel. FASEB J. 25:2296-304