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ANDREA VENERANDO

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AFFIDAMENTO ESTERNO

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Graduated in Chemistry and Pharmaceutical Techniques at the University of Padova (Italy) in 2005 with a thesis entitled “Chemical synthesis and structural-functional characterization of p13 protein from Human T-cell leukemia virus (HTLV-1)”. He has got his PhD in Biochemistry and Biophysics at the University of Padova (Italy) in 2010 (Thesis entitled “Isoform specific phosphorylation of p53 Ser-20 by CK1 is dictated by both a local consensus and a remote docking site”). Member of the Italian Society of Biochemistry (from 2011 to date). In 2017 he obtained the National Scientific Qualification for the sector 05/E1 (General Biochemistry, SSD BIO/10) for Associate Professor. He obtained many fellowships with Pharmaceutical Companies and Research Institutes (Novartis, Switzerland, 2006; Venetian Institute of Molecular Medicine, Italy, 2007-2010; Division of Medical Sciences, University of Dundee, Ninewells Hospital, UK, 2012; CNR, Italy, 2012-2013; IERFC, Milan, Italy, 2014-15). Senior Postdoc at the Dept. of Biomedical Sciences, University of Padova (Italy) from 2014 to 2018, he became assistant professor (RTDa) in Biochemistry at the Dept. of Comparative Biomedicine and Food Science, University of Padova in March 2018, where he is a member of the “Commissione per la Ricerca Scientifica” of the Department. Consultant for the Istituto Europeo per la Ricerca sulla Fibrosi Cistica – IERFC, in Milan (Italy). Review Editor for Frontiers in Microbiology, Frontiers in Chemistry, Cancers and Pflügers Archiv - European Journal of Physiology. He participated at several national and international meetings and congresses as speaker and/or poster presenter. He has been involved in many projects with national and international collaborations, among them grants from Research Foundation for Cystic Fibrosis Fondazione-ONLUS in 2009, 2011, 2016, 2017 and 2019 and E-RARE grant from European Commission in 2014. Winner of Progetto Giovani Studiosi in 2013 and Progetto Senior in 2015 with the project “Functional links between protein kinase CK2 and the Cystic Fibrosis Transmembrane-Conductance Regulator (CFTR) disclose new perpectives in Cystic Fibrosis therapy” and “A new strategy to correct Cystic Fibrosis basic defect”, respectively (both funded by University of Padova). Principal Investigator and Coordinator of the project “A kinase-directed approach to rescue functionality of F508del CFTR” (funded by the Research Foundation for Cystic Fibrosis Fondazione-ONLUS, grant number FFC#7/2014). Inventor in the international patent application n. 18208109.1-1112 “Analogues of cysteamine as therapeutic agents for cystic fibrosis” (05.11.19).

Notices

Office hours

  • Everyday by previous appointment by e-mail (andrea.venerando@unipd.it)

Research Area

The main area of interest has been protein kinases, and in particular protein kinase CK1 and CK2. The main research field regards the study of the molecular and cellular mechanisms regulating by alteration of protein kinases signalling. Other research field has been the identification, development and characterization of new compounds able to affect protein kinases as pharmacological targets. In the last years he has devoted his attention to the Cystic Fibrosis and in particular to protein kinases deregulation in this pathology with a good publications record as well as funded grants. In addition, he studied the cellular and molecular mechanisms that involve the F508delCFTR mutation, particularly its function, stability and trafficking at plasma membrane. He has devoted his attention to test new “natural” compound to regulate function and stability of CFTR at PM. Currently, he is studying new biotechnological applications of peculiar iron oxide nanoparticles, named Surface Active Maghemite Nanoparticles (SAMN), in the field of cell tracking, target driven drug delivery and purification of biomolecules from complex biological and environmental samples.