Address book
Contacts
NATASCIA TISO
Position
Professoressa Associata
Structure
Address
VIALE GIUSEPPE COLOMBO, 3 - VIA UGO BASSI, 58/B - PADOVA
Telephone
0498276302
PUBLICATIONS:
102 publications; 5655 citations; 55 cit/article; h-index=33 (Google Scholar: h-index=38)
>100 international and >50 national presentations
TITLES AND WORK EXPERIENCES
1994: Degree in Biological Sciences, Biomolecular Course, 110/110 cum laude
1996: Official State Exam as Professional Biologist
1997: Visiting Scientist at the University of Toronto, Ontario, Canada
1998: PhD in Genetic Sciences, Univ. of Bologna, Ferrara and Padua
1999-2000: Post-doctorate in Genetics of Hereditary Cardiomyopathies, Univ. Padua
2001-2007: EU Research Collaborator - Model organism: zebrafish (Danio rerio)
2005: Stage at MPI Tuebingen, Germany, Lab. of Nobel Prize Prof. C.N. Volhard
2007-2015: University Researcher, Dept. of Biology, UniPD
2015-present: Associate Professor, Dept. of Biology, UniPD
AWARDS AND SCHOLARSHIPS
1997: Telethon annual scholarship for training abroad
1997: "Lions Club Verona Europa" award for arrhythmogenic cardiomyopathy
2001: "Martino Arrigoni" Award for Congenital Cardiopathies, Rotary Club BL
2003: "Alberto Monroy" Award for the MBL course, USA, University of Palermo
2003: L'Oreal-UNESCO Award (on ARVD) for Women and Science in Italy
2003: Howard Hughes Medical Institute Award (MBL Embryology Course 2003) USA
2008-present: Annual Mobility Fellowship Winner, Univ. Padova / Univ. Freiburg Exchange
2013: Poster Prize COB, European Zebrafish Meeting, Barcelona, Spain
2017: Poster Prize EASD-ISG / BCW, 2nd EASD-ISG / BCW Joint Meeting, Dresden, Germany
FUNDING
2002-2003: Young Researcher Funding on: ARVD, UniPD
2004: EU Research Collaborator II Level, Co-PI EU Project ZF-MODELS
2008: Curator of the Didactic Fund Project (40,000 Euros), UniPD
2009: PI - University Project (on: Alagille Syndrome). Euro 60,000, UniPD
2009-present: holder of DOR funds - Ministry of Education, University and Research
2009: Curator of the Didactic Fund Project (40,000 Euros), UniPD
2009: "Large Equipment" Project Curator (Euro 220,000), UniPD
2011: Visiting Scientist Project winner (Euro 5000), UniPD
2011: Curator of the Didactic Fund Project (86,000 Euros), UniPD
2012: PI Unit, Finalized Research Proj. (on: CH) (Euro 59.124),UniMI
2013: Junior Post-doc Biennial Fellowship (on CH), (25,000x2 Euros)
2013: Co-PI University Proj. "Optozen" (Euro 8,000) (on: Imaging in ZF), UniPD
2014: Co-PI University Proj. "TIGRE" (55,000 euros), UniPD
2015: PI in the project "POLYGON" (50,000 euros), AFM-Telethon, France
2018: Unit Pi, project "SHoCD" (350,000 euros), Cariparo Foundation, Padova, Italy
2019: CoPI in the Italian Telethon Project "ZIPPY" GGP19287 (Euro 188.100), Italy
TEACHING AND ACADEMIC ACTIVITIES
2007-2011: holder of the course "Molecular Biology of Development, Mod. B", Sc. Sciences, UniPD
2011-present: holder of the course "Model Organisms in Biology", School of Sciences, UniPD
2015-present: holder of the courses "Applied Biology" and "Genetics", School of Psychology, UniPD
Associations: AGI (Italian Genetic Association), European Zebrafish Society, Science Advisory and Healthcare Advisory Board, GSA (Genetics Society of America), ASBMB, SBMR, European Society for Fish Models in Biology and Medicine
Reviewer for about 20 international journals with IF and peer review
WEB SITES:
ZFIN: http://zfin.org/cgi-bin/webdriver?MIval=aa-persview.apg&OID=ZDB-PERS-020116-8
ResearchGate: https://www.researchgate.net/profile/Natascia_Tiso/
Notices
Office hours
Wednesday from 12:00 to 13:00
at Ufficio Prof. N. Tiso - I Piano Sud - Lab. 09-10 - Centro Interdipartimentale Vallisneri
Si prega di concordare l'appuntamento via e-mail (natascia.tiso@unipd.it) o per telefono (049/8276302)
Teachings
- MODEL ORGANISMS IN BIOLOGICAL RESEARCH, AA 2023 (SCP3054415)
- APPLIED BIOLOGY, AA 2022 (PSN1029563)
- HUMAN AND BEHAVIORAL GENETICS, AA 2022 (PSQ0090898)
- MODEL ORGANISMS IN BIOLOGICAL RESEARCH, AA 2022 (SCP3054415)
- APPLIED BIOLOGY, AA 2021 (PSN1029563)
- HUMAN AND BEHAVIORAL GENETICS, AA 2021 (PSQ0090898)
- MODEL ORGANISMS IN BIOLOGICAL RESEARCH, AA 2021 (SCP3054415)
- APPLIED BIOLOGY, AA 2020 (PSN1029563)
- GENETICS, AA 2020 (PSO2043598)
- MODEL ORGANISMS IN BIOLOGICAL RESEARCH, AA 2020 (SCP3054415)
- APPLIED BIOLOGY, AA 2019 (PSN1029563)
- GENETICS, AA 2019 (PSO2043598)
- MODEL ORGANISMS IN BIOLOGICAL RESEARCH, AA 2019 (SCP3054415)
- APPLIED BIOLOGY, AA 2018 (PSN1029563)
- GENETICS, AA 2018 (PSO2043598)
- MODEL ORGANISMS IN BIOLOGICAL RESEARCH, AA 2018 (SCP3054415)
- APPLIED BIOLOGY, AA 2017 (PSN1029563)
- GENETICS, AA 2017 (PSO2043598)
- MODEL ORGANISMS IN BIOLOGICAL RESEARCH, AA 2017 (SCP3054415)
- APPLIED BIOLOGY, AA 2016 (PSN1029563)
- GENETICS, AA 2016 (PSO2043598)
- MODEL ORGANISMS IN BIOLOGICAL RESEARCH, AA 2016 (SCP3054415)
- APPLIED BIOLOGY, AA 2015 (PSN1029563)
- GENETICS, AA 2015 (PSO2043598)
- MODEL ORGANISMS IN BIOLOGICAL RESEARCH, AA 2015 (SCP3054415)
- MODEL ORGANISMS IN BIOLOGICAL RESEARCH, AA 2014 (SCP3054415)
- MODEL ORGANISMS IN BIOLOGICAL RESEARCH, AA 2013 (SCP3054415)
Publications
Most significant publications in the last 5 years:
Facchinello N, Laquatra C, Locatello L, Beffagna G, Brañas Casas R, Fornetto C, Dinarello A, Martorano L, Vettori A, Risato G, Celeghin R, Meneghetti G, Santoro MM, Delahodde A, Vanzi F, Rasola A, Dalla Valle L, Rasotto MB, Lodi T, Baruffini E, Argenton F, Tiso N. Efficient clofilium tosylate-mediated rescue of POLG-related disease phenotypes in zebrafish. Cell Death Dis. 2021 Jan 19;12(1):100. doi: 10
miR-7 Controls the Dopaminergic/Oligodendroglial Fate through Wnt/β-catenin Signaling Regulation.
Adusumilli L, Facchinello N, Teh C, Busolin G, Le MT, Yang H, Beffagna G, Campanaro S, Tam WL, Argenton F, Lim B, Korzh V, Tiso N.
Cells. 2020 Mar 13;9(3):E711. doi: 10.3390/cells9030711.
Mutation in the mouse histone gene Hist2h3c1 leads to degeneration of the lens vesicle and severe microphthalmia.
Vetrivel S, Tiso N, (...), Graw J.
Exp Eye Res. 2019 Apr 13. pii: S0014-4835(18)30702-4. doi: 10.1016/j.exer.2019.03.024.
Loss of cardiac Wnt/β-catenin signalling in Desmoplakin-deficient AC8 zebrafish models is rescuable by genetic and pharmacological intervention.
Giuliodori A, Beffagna G, Marchetto G, Fornetto C, Vanzi F, Toppo S, Facchinello N, Santimaria M, Vettori A, Rizzo S, Della Barbera M, Pilichou K, Argenton F, Thiene G, Tiso N, Basso C.
Cardiovasc Res. 2018 Mar 7. doi: 10.1093/cvr/cvy057.
Tcf7l2 plays pleiotropic roles in the control of glucose homeostasis, pancreas morphology, vascularization and regeneration.
Facchinello N, Tarifeño-Saldivia E, Grisan E, Schiavone M, Peron M, Mongera A, Ek O, Schmitner N, Meyer D, Peers B, Tiso N, Argenton F.
Sci Rep. 2017 Aug 29;7(1):9605. doi: 10.1038/s41598-017-09867-x.
Optical mapping of neuronal activity during seizures in zebrafish.
Turrini L, Fornetto C, Marchetto G, Müllenbroich MC, Tiso N, Vettori A, Resta F, Masi A, Mannaioni G, Pavone FS, Vanzi F.
Sci Rep. 2017 Jun 8;7(1):3025. doi: 10.1038/s41598-017-03087-z.
Sox10 contributes to the balance of fate choice in dorsal root ganglion progenitors.
Delfino-Machín M, Madelaine R, Busolin G, Nikaido M, Colanesi S, Camargo-Sosa K, Law EW, Toppo S, Blader P, Tiso N, Kelsh RN.
PLoS One. 2017 Mar 2;12(3):e0172947. doi: 10.1371/journal.pone.0172947. eCollection 2017.
Monitoring Wnt Signaling in Zebrafish Using Fluorescent Biosensors.
Facchinello N, Schiavone M, Vettori A, Argenton F, Tiso N.
Methods Mol Biol. 2016;1481:81-94. doi: 10.1007/978-1-4939-6393-5_9.
CD271 Down-Regulation Promotes Melanoma Progression and Invasion in Three-Dimensional Models and in Zebrafish.
Saltari A, Truzzi F, Quadri M, Lotti R, Palazzo E, Grisendi G, Tiso N, Marconi A, Pincelli C.
J Invest Dermatol. 2016 Oct;136(10):2049-2058. doi: 10.1016/j.jid.2016.05.116. Epub 2016 Jun 18.
JAG1 Loss-Of-Function Variations as a Novel Predisposing Event in the Pathogenesis of Congenital Thyroid Defects.
de Filippis T, Marelli F, Nebbia G, Porazzi P, Corbetta S, Fugazzola L, Gastaldi R, Vigone MC, Biffanti R, Frizziero D, Mandarà L, Prontera P, Salerno M, Maghnie M, Tiso N, Radetti G, Weber G, Persani L.
J Clin Endocrinol Metab. 2016 Mar;101(3):861-70. doi: 10.1210/jc.2015-3403. Epub 2016 Jan 13.
Venous-derived angioblasts generate organ-specific vessels during zebrafish embryonic development.
Hen G, Nicenboim J, Mayseless O, Asaf L, Shin M, Busolin G, Hofi R, Almog G, Tiso N, Lawson ND, Yaniv K.
Development. 2015 Dec 15;142(24):4266-78. doi: 10.1242/dev.129247. Epub 2015 Nov 2.
Research Area
Research Areas: Human Genetics, Genetics - Developmental Dynamics and Molecular Biology, Zebrafish (Danio rerio) and Human Pathology.
Research lines:
a) Use of zebrafish as a model for human arrhythmogenic cardiomyopathy
b) Use of zebrafish as a model for human mitochondrial disorders
c) Use of zebrafish as a model for the FGR human condition
d) Use of zebrafish for in vivo analysis of cell signaling
e) Use of zebrafish for the analysis and treatment of human cancer cells.
Techniques: production and analysis of transgenic zebrafish lines, biosensors and mutants; classical and confocal microscopy; microinjection of constructs, mRNA and morpholino oligos into zebrafish zygotes; xeno-transplantation of human tumor cells; immunohistochemistry and in situ hybridization on whole embryo; routine techniques in genetics and molecular biology; gene targeting via CRISPR-Cas9 technology.
Thesis proposals
Master's thesis topics:
a) Use of zebrafish as a model for human arrhythmogenic cardiomyopathy
b) Use of zebrafish as a model for human mitochondrial disorders
c) Use of zebrafish as a model for the FGR human condition
d) Use of zebrafish for in vivo analysis of cell signaling
e) Use of zebrafish for the analysis and treatment of human cancer cells.
Bachelor's thesis; activities and techniques on display:
a) Practical activities for laboratory management (cleaning of work areas, sterilization of materials, instrumentation calibration and maintenance)
b) Basic techniques in molecular biology (nucleic acid extraction, PCR and genotyping, gel electrophoresis)
c) Embryological techniques on the zebrafish model (collection and manipulation of fertilized eggs, observation of developmental stages, fixation, immuno-histochemistry and in situ hybridization, in vivo and post-mortem observations and documentation by classical bright-field/fluorescence and confocal optical microscopy.
